13754-86-4 Usage
Uses
Different sources of media describe the Uses of 13754-86-4 differently. You can refer to the following data:
1. ? ;Reactant in synthesis of psammopemmin A as antitumor agent1? ;Reactant in synthesis of a 1,3,4,5-tetrahydrobenzindole β-ketoesters and tricyclic tetrahydrobenzindoles via C-H insertion reactions2? ;Reactant in preparation of tricyclic indole and dihydroindole derivatives as inhibitors of guanylate cyclase3? ;Reactant in preparation of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of (halobenzyl)pyrroles4? ;Reactant in enantioselective preparation of arylalkenyl indoles via asymmetric C-H insertion of rhodium carbenoids foll
2. 1,5,6,7-Tetrahydro-4H-indol-4-one, is a versatile building block used for the synthesis of more complex pharmaceutical compounds. It can be used for the preparation of Psammopemmin A.
General Description
Iodination of 1,5,6,7-tetrahydro-4H-indol-4-one using 1-chloromethyl--4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetra-fluoroborate) yields α-iodo derivative as the main product.
Check Digit Verification of cas no
The CAS Registry Mumber 13754-86-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,5 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13754-86:
(7*1)+(6*3)+(5*7)+(4*5)+(3*4)+(2*8)+(1*6)=114
114 % 10 = 4
So 13754-86-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO/c10-8-3-1-2-7-6(8)4-5-9-7/h4-5,9H,1-3H2
13754-86-4Relevant articles and documents
ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR
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Paragraph 0208; 0211; 0212, (2017/06/12)
The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.
Synthesis of N-aryl-4,5,6,7-tetrahydroindoles
Lee, In-Sook Han,Kwon, Min Jin,Lee, Chang Kiu
scheme or table, p. 341 - 343 (2012/03/10)
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Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase
Spyridonidou, Katerina,Fousteris, Manolis,Antonia, Marazioti,Chatzianastasiou, Athanasia,Papapetropoulos, Andreas,Nikolaropoulos, Sotiris
supporting information; experimental part, p. 4810 - 4813 (2010/04/26)
The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.