1446507-68-1

Basic information

• Product Name: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine
• Synonyms: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine
• CAS NO: 1446507-68-1
• Molecular Formula: C₁₅H₇ClF₆N₆
• Molecular Weight: 420.6996992
• Mol File: 1446507-68-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 514.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.582±0.06 g/cm3(Predicted)
• PKA: 1.47±0.38(Predicted)
• CAS DataBase Reference: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine(1446507-68-1)
• EPA Substance Registry System: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine(1446507-68-1)

Safety Data

• Hazardous Substances Data: 1446507-68-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine is a complex chemical compound with a molecular formula C15H7ClF6N6. It belongs to the class of triazine herbicides and is commonly used as a pesticide to control weeds, especially in agricultural and horticultural settings. This chemical is known for its strong herbicidal activity and is often found in various herbicide formulations. Its mode of action involves inhibiting the photosynthetic electron transport chain in target plants, leading to the disruption of their growth and development. The trifluoromethyl and chloro substituents on the pyridin-2-yl and pyridin-4-yl groups contribute to the compound's herbicidal properties, making it an effective and reliable tool for weed control in different crop systems. Nevertheless, it is important to follow safety guidelines when using and handling this chemical to minimize potential risks to human health and the environment.

Upstream product

• 887583-52-0 6-(trifluoromethyl)pyridine-2-carbonitrile 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 
• 1446507-38-5 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4-(1H,3H)-dione 
• 155377-05-2 6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester 
• 131747-42-7 6-(trifluoromethyl)pyridine-2-carboxylic acid 
• 368-48-9 2-(trifluoromethyl)pyridine 
• 1446507-40-9 2,4-dichloro-6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine 
• 147149-98-2 2-(trifluoromethyl)pyridin-4-amine 

Downstream Products

• 1446502-11-9 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol 

Relevant articles and documents

Compound with IDH mutant inhibitory activity, preparation method and application thereof

The invention belongs to the field of medicines, and particularly relates to a s-triazine compound with structural characteristics of a general formula I or a pharmaceutically acceptable salt thereof,a pharmaceutical composition and a preparation method thereof, and application of the s-triazine compound or the pharmaceutically acceptable salt and the pharmaceutical composition in preparation ofIDH2 mutant inhibitors. According to the invention, pharmacological experiment results show that the compound disclosed by the invention has an obvious inhibition effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process that alpha-ketoglutaric acid is catalyzed by mIDH2 to generate 2-hydroxyglutaric acid, and can be used for preparing drugs for preventing and/or treating various related diseases caused by IDH2 mutation, wherein the diseases comprise cancers carrying IDH2 mutation.

Substituted triazine-based IDH inhibitor optical isomers and applications thereof

The present invention belongs to the field of medical chemistry, and relates to a class of substituted triazine-based IDH inhibitor optical isomers and applications thereof, and specifically providesoptical isomers represented by a formula I or formula II or hydrates, solvates, crystals or pharmaceutically acceptable salts thereof, and a preparation method thereof, a pharmaceutical composition containing the optical isomers or hydrates, solvates, crystals or pharmaceutically acceptable salts thereof, and uses in treatment of cancer characterized by the presence of mutant isocitrate dehydrogenase 2. According to the present invention, the compounds have good inhibitory activity against IDH2, and can be used as the cancer treatment agents with advantages of high treatment effect and low side effect. The formulas I and II are defined in the specification.

Crystal form of triazine IDH inhibitor methanesulfonate (by machine translation)

The invention belongs to the field, and relates to a crystal form of mesylate of IDH inhibitor and a preparation method, and particularly relates to a crystal form of methanesulfonate of (S)-3 - (trifluoromethyl) pyridin -1 -yl) 4 - (6 - (trifluoromethyl) pyridin -2 - amino) -6 - 2 -4 -triaz -1-yl) pyrrolidine 3 -3 -2 - 5 - alcohol and a preparation method thereof, wherein the mesylate crystal form can be used for preparing a medicament for treating cancers, and a preparation method thereof. (by machine translation)