14814-17-6

Basic information

• Product Name: (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone
• Synonyms: (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone;Methanone, [4-(2-hydroxyethoxy)phenyl]phenyl-
• CAS NO: 14814-17-6
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.26986
• Mol File: 14814-17-6.mol

Chemical Properties

• Melting Point: 79-80 °C(Solv: heptane (142-82-5))
• Boiling Point: 421.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Dichloromethane, DMSO, Methanol
• PKA: 14.14±0.10(Predicted)
• CAS DataBase Reference: (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone(14814-17-6)
• EPA Substance Registry System: (4-(2-hydroxyethoxy)phenyl)(phenyl)methanone(14814-17-6)

Safety Data

• Hazardous Substances Data: 14814-17-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-(2-Hydroxyethoxy)phenyl)(phenyl)methanone is used as an intermediate in the synthesis of E-Ospemifene (O703005) for its role in lowering serum cholesterol. E-Ospemifene, the E-isomer of Ospemifene (O703000), exhibits anti-atherosclerotic properties and has estrogen-like effects, making it a valuable compound in the development of treatments for conditions related to cholesterol and cardiovascular health.
Additionally, this compound may have potential applications in other areas of the pharmaceutical industry, depending on its specific chemical properties and reactivity, which could be further explored for the development of new drugs and therapies.

Upstream product

• 75230-42-1 1-acetoxy-2-(4-benzoylphenoxy)ethane 
• 191332-05-5 2-(4-benzoylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether 
• 1892-43-9 2-(4-chlorophenoxy)ethanol 
• 100-47-0 benzonitrile 
• 34743-88-9 2-(4-bromophenoxy)ethanol 
• 335591-82-7 4-[2-(tert-butyldimethylsilyloxy)ethoxy]benzophenone 
• 1137-42-4 4-Hydroxybenzophenone 
• 6192-44-5 2-phenoxyethyl acetate 
• 96-49-1 [1,3]-dioxolan-2-one 
• 75-21-8 oxirane 
• 540-51-2 2-bromoethanol 
• 98-88-4 benzoyl chloride 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 1159136-29-4 3-chloro-propionic acid 2-(4-benzoylphenoxy)ethyl ester 
• 1197029-47-2 methyl 6-hydroxy-2-(4-(2-hydroxyethoxy)phenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate 
• 1197029-49-4 methyl 6-(2-bromo-2-methylpropanoyloxy)-2-(4-(2-(2-bromo-2-methylpropanoyloxy)ethoxy)phenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate 
• 869796-85-0 1-(4-(2-hydroxyethoxy)phenyl)-1-phenylprop-2-yn-1-ol 
• 34570-27-9 1-(2-methyl-2-propenoyloxy)-2-(4-benzoylphenoxy)ethane 

Relevant articles and documents

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m- and p-Chlorinated ω-phenoxyalcohols 1, were transformed into the corresponding lithium ω-(m- and p-lithiophenoxy)alkoxides 4, respectively, by successive deprotonation with n-butyllithium and subsequent chlorine-lithium exchange by lithium naphthalene radical anion in THF-methylcyclohexane. Lithium 2-(4-lithiophenoxy)ethoxide (4a′) was also prepared by bromine-lithium exchange of 2-(4-bromophenoxy)ethanol (2a′) with two equivalents of n-butyllithium. The organolithiums were modified with magnesium 2-ethoxyethoxide in order to avoid ortho-metallation of the above-mentioned substituted arenes. Subsequent reaction of these intermediates with the electrophiles carbon dioxide, benzophenone, benzonitrile and 0.5 equivalents of mercuric chloride yielded the expected m- and p-substituted (ω-hydroxyalkoxy)benzenes in yields ranging from 50 to 75%. The crystal structures of the organomercurials 8a′ and 8b′ have been determined and revealed the Hg atom to occupy a crystallographic center of symmetry in a linear C-Hg-C arrangement.

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