1482-98-0

Basic information

• Product Name: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO
• Synonyms: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO;(2S)-2,4-diaminobutanoicacidhydrochloride;(s)-(+)-2,4-diaminobutanoicacidhydrochloride;Butanoic acid, 2,4-diaMino-, Monohydrochloride, (S)-;L-alpha,gamma-Diaminobutyric acid monohydrochloride;(S)-2,4-Diaminobutanoic acid monohydrochloride
• CAS NO: 1482-98-0
• Molecular Formula: C₄H₁₂N₂O₂*2Cl
• Molecular Weight: 154.59534
• Product Categories: DAB (2,4-Diaminobutyric Acid);A - HPeptide Synthesis;Amino Acids;Modified Amino Acids;Unnatural Amino Acid Derivatives
• Mol File: 1482-98-0.mol

Chemical Properties

• Melting Point: 193 °C (dec.)(lit.)
• Boiling Point: 334.6°Cat760mmHg
• Flash Point: 156.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.4E-05mmHg at 25°C
• BRN: 6086583
• CAS DataBase Reference: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO(CAS DataBase Reference)
• NIST Chemistry Reference: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO(1482-98-0)
• EPA Substance Registry System: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO(1482-98-0)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 1482-98-0(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research and Drug Development:
L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO is used as a chemical compound in biochemical research and drug development for its unique properties and potential applications in the synthesis of peptide-based drugs.
Used in Antimicrobial Applications:
L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO is used as an antimicrobial agent due to its ability to exhibit biological activities against various microorganisms.
Used in Antitumor Applications:
L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO is used as an antitumor agent for its potential therapeutic applications in cancer treatment, as it has been found to possess antitumor properties.
Used in Neurodegenerative Disease Research:
L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO is used in the study of neurodegenerative diseases, as it has shown potential therapeutic applications in this field.
Used in Chemical and Biochemical Assays:
L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO is used as a reagent in chemical and biochemical assays, taking advantage of its chemical properties for various analytical purposes.

InChI:InChI=1/C4H10N2O2.ClH/c5-2-1-3(6)4(7)8;/h3H,1-2,5-6H2,(H,7,8);1H/t3-;/m0./s1

Upstream product

• 127531-09-3 (S)-3-Cyano-2-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-propionic acid ethyl ester 
• 103668-08-2 (R)-2,4-Diamino-butyric acid ethyl ester; hydrochloride 
• 73143-97-2 (S)-2,4-diamino-butyric acid ; hydrobromide 
• 1190-46-1 N-γ-acetyl-L-2,4-diaminobutyrate 
• 34404-27-8 N^α,N^γ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid 

Downstream Products

• 97347-23-4 N^α,N^γ-diBoc-L-2,4-diaminobutyric acid p-nitrobenzyl ester 
• 117106-22-6 (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid 
• 55478-23-4 (S)-2,4-bis(((benzyloxy)carbonyl)amino)butanoic acid 
• 4128-00-1 (3S)-3-aminopyrrolidin-2-one 
• 34404-27-8 N^α,N^γ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid 
• 25139-87-1 ⁽⁵⁾-(+)(D)-N,N'-Ditosyl-2,4-diamino-butanol 
• 2130-77-0 (S)-2-Amino-4-benzyloxycarbonylamino-butyric acid 
• 126581-98-4 DPAB-L-DBA (trans) 
• 1217645-10-7 (R)-2,4-bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid 

Relevant articles and documents

SYNTHESIS OF CYCLIC AMIDINES

The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield α-chloro-γ-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner.

The synthesis of unusual tetrahydropyrimidine amino acids

The synthesis of derivatives of 2-(1-an-aminoalkyl)-4-carboxy-3,4,5,6-tetrahydropyrimidines, unusual amino acids isolated from bacterial siderophores, is described, from condensation of N-protected amino acids imidates or thiomidates with 2,4-diaminobutyrylglycine methyl ester.

ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY PURE NATURAL S(+) OR UNNATURAL R(-) DABA

After optimization of the reaction conditions, optically pure S(+) DABA is obtained in more than 80percent overall yield.A modell is proposed to explain the dependence of asymmetric induction on the nature of the counter ion (Li(1+), Mg(2+), Bu4N(1+)).