15298-67-6

Basic information

• Product Name: 1-Benzylideneindan
• Synonyms: 1-(Benzylidene)-2,3-dihydro-1H-indene;1-Benzylideneindan
• CAS NO: 15298-67-6
• Molecular Formula: C₁₆H₁₄
• Molecular Weight: 206.28
• Mol File: 15298-67-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzylideneindan(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzylideneindan(15298-67-6)
• EPA Substance Registry System: 1-Benzylideneindan(15298-67-6)

Safety Data

• Hazardous Substances Data: 15298-67-6(Hazardous Substances Data)

Usage

Structure

Highly aromatic compound with an indane core and a benzylidene group attached

Reactivity

Versatile in forming various types of chemical bonds

Usage

Commonly used as a reactant in organic synthesis

Applications

Building block in the synthesis of pharmaceuticals, dyes, and materials

Biological activities

Studied for potential anti-inflammatory and anti-tumor properties

Significance

Valuable molecular tool in organic chemistry

Research areas

Pharmaceutical and material science research

Upstream product

• 83-33-0 inden-1-one 
• 6921-34-2 benzylmagnesium chloride 
• 21844-32-6 1-(2-Brom-ethyl)-2-triphenylphosphoniomethyl-benzol-bromid 
• 100-52-7 benzaldehyde 
• 22495-71-2 3-benzyl-1H-indene 
• 95-13-6 1-indene 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 38256-56-3 1-(2-bromo-ethyl)-2-bromomethyl-benzene 
• 100-39-0 benzyl bromide 
• 23181-84-2 1-indenylsodium 
• 136015-72-0 1-(3-butynyl)-2-bromobenzene 
• 98-80-6 phenylboronic acid 
• 33598-24-2 (4-chloro-2-butyn-1-yl)benzene 
• 71-43-2 benzene 

Downstream Products

• 1138785-08-6 2-hydroxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one 
• 1354727-81-3 C₁₆H₁₄O₂ 
• 16458-22-3 1-benzyl azulene 
• 65-85-0 benzoic acid 
• 83-33-0 inden-1-one 
• 4831-01-0 1-benzyl-2,3-dihydro-1H-indene 

Relevant articles and documents

Palladium-catalyzed cascade cyclization-coupling reactions of 2-bromo-1,6-enynes with organoboronic acids

2-Bromo-1,6-enynes 5 with a palladium catalyst would form the alkenylpalladium intermediates via an intramolecular Heck reaction, which were cross-coupled with various organoboronic acids 8 to give the cyclization-coupling products 6 in synthetically valuable yields.

Synthesis of substituted α-tetralones and substituted 1-naphthols via regioselective ring expansion of 1-acyl-1-indanol skeleton

Substituted 1-acyl-1-indanols were prepared using the corresponding readily commercially available substituted indanones as starting materials. Treatment of each 1-acyl-1-indanol derivative with sodium methoxide in hot methanol furnished a regiospecific 2-hydroxy-α-tetralone derivative, which was an α-keto rearrangement product. Each substituted 2-hydroxy-α-tetralone then underwent dehydration to afford the corresponding 1-naphthol derivative.