15573-67-8

Basic information

• Product Name: 4-Hydroxyphenylglyoxylic acid
• Synonyms: 4-Hydroxyphenylglyoxylic acid
• CAS NO: 15573-67-8
• Molecular Formula: C₈H₆O₄
• Molecular Weight: 166.13084
• EINECS: 259-205-0
• Mol File: 15573-67-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 358.9°Cat760mmHg
• Flash Point: 185°C
• Appearance: /
• Density: 1.457g/cm³
• Vapor Pressure: 8.95E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Hydroxyphenylglyoxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxyphenylglyoxylic acid(15573-67-8)
• EPA Substance Registry System: 4-Hydroxyphenylglyoxylic acid(15573-67-8)

Safety Data

• Hazardous Substances Data: 15573-67-8(Hazardous Substances Data)

Usage

Description

4-Hydroxyphenylglyoxylic acid is a chemical compound with the molecular formula C8H6O4, belonging to the phenylglyoxylic acid derivatives. It features a hydroxyl group attached to the phenyl ring, which endows it with potential biological properties and applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-Hydroxyphenylglyoxylic acid is used as an enzyme inhibitor for its ability to inhibit enzymes involved in the biosynthesis of neurotransmitters, such as tyrosine hydroxylase and phenylalanine hydroxylase. This makes it a potential candidate for the development of drugs targeting neurological disorders.
Used in Organic Synthesis:
4-Hydroxyphenylglyoxylic acid is used as a building block in the synthesis of pharmaceutical compounds, contributing to the creation of new drugs with therapeutic potential.
Used in Dye Industry:
4-Hydroxyphenylglyoxylic acid is used as a building block for dyes, owing to its chemical structure that can be modified to produce a range of colorants for various applications.
Used in Agrochemical Industry:
4-Hydroxyphenylglyoxylic acid is utilized as a building block for agrochemicals, potentially contributing to the development of new pesticides or other agricultural chemicals.
Used in Fine Chemicals Industry:
4-Hydroxyphenylglyoxylic acid is employed as a building block for fine chemicals, which are high-purity, specialty chemicals used in various industries, including pharmaceuticals, fragrances, and flavorings.

InChI:InChI=1/C8H6O4.Na/c9-6-3-1-5(2-4-6)7(10)8(11)12;/h1-4,9H,(H,11,12);/q;+1/p-1

Upstream product

• 7664-93-9 sulfuric acid 
• 15535-99-6 4-amino-α-oxophenylacetic acid 
• 70080-54-5 4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester 
• 26787-78-0 amoxicillin 
• 2628-17-3 4-Vinylphenol 
• 99-93-4 4-Hydroxyacetophenone 
• 6324-01-2 p-hydroxyphenylglycine 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 38250-16-7 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester 
• 13244-75-2 (S)-α,4-dihydroxy-benzeneacetic acid 
• 75318-43-3 4,5-dichloro-1,2,3-dithiazolium chloride 
• 108-95-2 phenol 
• 76590-59-5 4-(4-Hydroxy-phenyl)-2-trifluoromethyl-4H-oxazol-5-one 

Downstream Products

• 156-38-7 4-hydroxyphenylacetate 
• 1198-84-1 4-hydroxymandelic acid 
• 76590-55-1 2-(4-hydroxy-3,5diiodophenyl)-2-oxoacetic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 99-96-7 4-hydroxy-benzoic acid 
• 121719-58-2 3-<(4-hydroxyphenyl)glyoxyloylamino>nocardicinic acid sodium salt 
• 32507-81-6 6-(4-hydroxyphenyl)-8-D-ribitylpteridine-2,4,7(1H,3H,8H)-trione 
• 113288-81-6 C₂₅H₂₁N₇O₃ 
• 136205-60-2 isobutyl p-hydroxybenzoylformate 
• 38250-16-7 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester 
• 66340-75-8 [(Z)-4-Bromo-3-hydroxy-benzyloxyimino]-(4-hydroxy-phenyl)-acetic acid 
• 65951-41-9 (4-Hydroxy-phenyl)-[(Z)-methoxyimino]-acetic acid 

Relevant articles and documents

ONE-STEP SYNTHESIS OF α-HYDROXY ACIDS VIA REDUCTIVE DOUBLE CARBONYLATION OF ORGANIC HALIDES

Palladium-catalyzed carbonylation of organic halides with water in the presence of calcium hydroxide or lithium hydroxide in primary or secondary alcoholic solvents afforded α-hydroxy acids.

Synthesis of α-Keto Acids via Oxidation of Alkenes Catalyzed by a Bifunctional Iron Nanocomposite

An efficient methodology for synthesis of α-keto acids via oxidation of alkenes using TBHP as oxidant catalyzed by a bifunctional iron nanocomposite has been established. A variety of alkenes with different functional groups were smoothly oxidized into their corresponding α-keto acids in up to 80% yield. Moreover, the bifunctional iron nanocomposite catalyst showed outstanding catalytic stability for successive recycles without appreciable loss of activity.

Electrochemical oxidation of amoxicillin on carbon nanotubes and carbon nanotube supported metal modified electrodes

The electrolysis of amoxicillin (AMX) was carried out on CNT, Pt/CNT and Ru/CNT modified electrodes based on Carbon Toray in 0.1 M NaOH, 0.1 M NaCl and 0.1 M Na2CO3/NaHCO3 buffer (pH 10) media with the aim of studying the significance of two factors, electrode material and pH, on the oxidative degradation and mineralization of AMX. For this purpose, the electrolysis products were identified by HPLC-MS and GC–MS, and quantified by HPLC-UV-RID and IC. The highest carbon mineralization efficiency, corresponding to 30% of the oxidized AMX, was found for Pt/CNT modified electrode in carbonate buffer medium. Regarding to the AMX conversion, the results show that the effect of pH is higher than that of the electrode material. Principal component analysis allowed to determine the experimental parameters vs. product distribution relationship and to elucidate the oxidation pathways for the studied electrodes. The results show that the hydroxylation of the aromatic ring and the nitrogen atom play an important role on the efficient degradation of AMX.

Synthesis of arylglyoxylic acids and their collision-induced dissociation

A variety of substituted arylglyoxylic acids (2a-g) were synthesized via oxidation of the corresponding aryl-methylketones (1a-e) using selenium dioxide or Friedel-Crafts acylation of phenol (3) with ethyl chlorooxoacetate and further transformations. It was found that the arylglyoxylic acids (2) undergo facile unimolecular dissociation with loss of carbon monoxide to give the corresponding arylcarboxylic acids (7) under collisionally induced mass spectrometric conditions. Copyright Taylor & Francis Group, LLC.