34917-91-4

Basic information

• Product Name: 4'-hydroxy-2-methylpropiophenone
• Synonyms: 4'-hydroxy-2-methylpropiophenone;4-Hydroxyisobutyrophenone;1-(4-Hydroxyphenyl)-2-methyl-1-propanone;1-Propanone, 1-(4-hydroxyphenyl)-2-Methyl-;1-(4-hydroxyphenyl)-2-methylpropan-1-one
• CAS NO: 34917-91-4
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• EINECS: 252-287-9
• Mol File: 34917-91-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 303.4°Cat760mmHg
• Flash Point: 128.1°C
• Appearance: /
• Density: 1.074g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.89±0.26(Predicted)
• CAS DataBase Reference: 4'-hydroxy-2-methylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-hydroxy-2-methylpropiophenone(34917-91-4)
• EPA Substance Registry System: 4'-hydroxy-2-methylpropiophenone(34917-91-4)

Safety Data

• Hazardous Substances Data: 34917-91-4(Hazardous Substances Data)

Usage

General Description

4'-hydroxy-2-methylpropiophenone, also known as p-Hydroxyacetophenone, is a chemical compound that belongs to the class of aromatic ketones. It is a yellowish crystalline solid with a sweet odor, and it is commonly used as a fragrance ingredient in perfumes and cosmetic products. The compound is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, 4'-hydroxy-2-methylpropiophenone has antioxidant properties and can be utilized as a preservative in various products. Overall, it is a versatile chemical with multiple uses in different industries.

Upstream product

• 20279-29-2 phenyl isobutyrate 
• 100-66-3 methoxybenzene 
• 5659-93-8 2,2-Dimethylmalonyl chloride 
• 501333-91-1 1-{4-(methoxymethoxy)phenyl}-2-methylpropan-1-one 
• 15573-67-8 pisolithin A 
• 78-84-2 isobutyraldehyde 
• 99-93-4 4-Hydroxyacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 70-70-2 4-hydroxypropiophenone 
• 108-95-2 phenol 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 79-30-1 isobutyryl chloride 

Downstream Products

• 2040-20-2 4-methoxyisobutyrophenone 
• 92251-99-5 1-(4-methacryloyloxy-phenyl)-2-methyl-propan-1-one 
• 79570-15-3 1-[4-((E)-3,7-Dimethyl-octa-2,6-dienyloxy)-phenyl]-2-methyl-propan-1-one 
• 123-31-9 hydroquinone 
• 79-31-2 isobutyric Acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 1371592-00-5 tert-butyl 2-fluoro-4-{5-[(1R)-1-(4-isobutyrylphenoxy)propyl]-1,2,4-oxadiazol-3-yl}benzoate 
• 1160829-09-3 C₃₂H₃₉NO₆S 
• 117023-62-8 1-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-2-methyl-propan-1-one; compound with oxalic acid 
• 117022-48-7 1-[4-(3-chloropropoxy)phenyl]-2-methyl-1-propanone 
• 4167-74-2 4-isobutylphenol 

Relevant articles and documents

Visible light-induced C-C bond cleavage in a multicomponent reaction cascade allowing acylations of sulfoximines with ketones

Visible light induces C-C-bond cleavage reactions of ketones, which can be utilized forN-acylations of sulfoximines. No (photo)catalyst is required, and the reactions occur at ambient temperature in air. The substrate scope is broad for both ketones and sulfoximines. For convertingNH-sulfoximines, the presence of NBS is essential.

Method for preparing aryl ketone based on iron-catalyzed free radical-free radical coupling reaction such as ketonic acid decarboxylation and fatty aldehyde de-carbonylation

The invention discloses a method for preparing an aryl ketone derivative based on a free radical-free radical cross-coupling reaction such as ketonic acid decarboxylation and fatty aldehyde de-carbonylation. The method comprises the following steps: reacting aryl-substituted ketonic acid with fatty aldehyde under the catalytic action of ferric triacetylacetonate to generate an aryl ketone derivative; the gram-grade reaction can be realized by the method only by using 3mol% of an iron catalyst; and the method has the advantages of no need of consumption of a large amount of a Lewis acid catalyst or a stoichiometric organic metal reagent, mild reaction conditions, one-step reaction, few by-products, wide substrate application range and scalable reaction, and overcomes the defects of large catalyst consumption, insufficient functional group tolerance, many by-products and the like in the prior art.

An improved synthesis of hydroxy aryl ketones by fries rearrangement with methanesulfonic acid/methanesulfonic anhydride

Methanesulfonic acid treated with methanesulfonic anhydride effectively mediates the Fries rearrangement of aryl esters to give hydroxy aryl ketones with high yields. Georg Thieme Verlag Stuttgart · New York.