16053-39-7

Basic information

• Product Name: H-PHE-SER-OH
• Synonyms: H-PHE-SER-OH;L-PHENYLALANYL-L-SERINE;phenylalanylserine;(S)-2-((S)-2-AMino-3-phenylpropanaMido)-3-hydroxypropanoic acid;H-Phe-Ser-OH≥ 99% (TLC);Phe-Ser
• CAS NO: 16053-39-7
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.27
• Mol File: 16053-39-7.mol

Chemical Properties

• Boiling Point: 571.168°C at 760 mmHg
• Flash Point: 299.232°C
• Appearance: /
• Density: 1.322g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: -15°C
• PKA: 2.97±0.10(Predicted)
• CAS DataBase Reference: H-PHE-SER-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-SER-OH(16053-39-7)
• EPA Substance Registry System: H-PHE-SER-OH(16053-39-7)

Safety Data

• Hazardous Substances Data: 16053-39-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
H-PHE-SER-OH is used as an active pharmaceutical ingredient for its potential therapeutic effects. The dipeptide structure allows it to interact with specific biological targets, making it a promising candidate for the development of new drugs.
Used in Cosmetic Industry:
In the cosmetic industry, H-PHE-SER-OH is used as a key ingredient in skincare and beauty products due to its potential benefits for the skin, such as promoting collagen production and improving skin elasticity.
Used in Research and Development:
H-PHE-SER-OH is utilized as a research compound for studying the structure and function of peptides, as well as their interactions with biological systems. This helps in understanding the underlying mechanisms of various diseases and the development of targeted therapies.
Used in Food Industry:
The dipeptide H-PHE-SER-OH can be used in the food industry as a flavor enhancer or a functional ingredient, taking advantage of its unique taste and potential health benefits.
Used in Agricultural Industry:
H-PHE-SER-OH may also find applications in the agricultural industry, where it could be used as a component in the development of biopesticides or as a supplement to improve the nutritional value of animal feed.

InChI:InChI=1/C12H16N2O4/c13-9(6-8-4-2-1-3-5-8)11(16)14-10(7-15)12(17)18/h1-5,9-10,15H,6-7,13H2,(H,14,16)(H,17,18)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 111061-56-4 Fmoc-Ser(Trt)-OH 
• 1161-13-3 N-Cbz-L-Phe 
• 35661-40-6 N-Fmoc L-Phe 
• 71989-33-8 Fmoc-Ser(tBu)-OH 
• 135575-89-2 N-benzyloxycarbonyl-L-phenylalanyl-L-serine benzyl ester 

Downstream Products

• 56-45-1 L-serin 
• 63-91-2 L-phenylalanine 
• 521305-75-9 (S)-2-((S)-2-Acryloylamino-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester 
• 368424-85-5 Phenylalanylserine methyl ester 

Relevant articles and documents

Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics

We report highly efficient two-step procedures for the synthesis of 1,3-oxazole-, thiazole-, and imidazole-containing peptides on solid phase from dipeptides composed of C-terminal threonine, serine, cysteine, or diaminopropionic acid by using different cyclodehydration procedures followed or preceded by oxidation. The methods are compatible with Fmoc solid-phase peptide synthesis conditions and with N-Fmoc, N-Boc, N-Cbz, and N-Alloc protecting groups.

γ-Valerolactone (GVL): An eco-friendly anchoring solvent for solid-phase peptide synthesis

Due to the hazardous nature of CH2Cl2, regulatory authorities have imposed restrictions to minimize or even stop its use. It has therefore become imperative to identify environmentally benign solvents to replace it. Here we report on a bio derived solvent, γ-valerolactone, for the incorporation of the first amino acid onto p-alkoxybenzyl alcohol resin in solid-phase peptide synthesis. Satisfactory loading values (by a spectrophotometric method) were achieved. Furthermore, racemization and dipeptide formation were also checked and found to be acceptable.

Biosynthesis of Hyalodendrin and Didethiobis(methylthio)hyalodendrin, Sulphur-containing 2,5-Dioxopiperazines of the 3S,6S Series

cyclo-(L-Phe-L-Ser) 8, a known biosynthetic precursor of the (3R,6R)-epidithiodioxopiperazine gliotoxin 4, was efficiently incorporated (42percent), in Hyalodendron sp. (FSC-601) cultures, into the 3S,6S metabolite didethiobis(methylthio)hyalodendrin (DBH) 7 without significant change in the 3H:14C ratio.None of the three diasteromers of cyclo-(L-Phe-L-Ser) was incorporated into DBH to any significant extent.The 13C label from cyclo-(L-Phe-L-Ser) was located, in the expected site, in DBH by 13C NMR spectroscopy.Gliotoxin derived in Gliocladium virens from the doubly labelled precursor 8 was degraded to locate, in similar manner, the 14C label.The N-methyl derivative 16 of cyclo-(L-Phe-L-Ser) was not incorporated detectably into either gliotoxin or DBH.Radioactivity from the doubly labelled, linear dipeptides 17 and 18, possible precursors for the cyclodipeptide 8, was incorporated with moderate efficiency into gliotoxin.However, the 3H:14C ratios for the dipeptides and the derived gliotoxin differd substantially, indicating that the peptides had undergone cleavage in the fungus before incorporation.