161126-00-7Relevant articles and documents
Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties
Kato, Komei,Ninomiya, Masayuki,Tanaka, Kaori,Koketsu, Mamoru
supporting information, p. 1808 - 1814 (2016/08/02)
Quercetin derivatives are widespread in the plant kingdom and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of quercetin derivatives, with a focus on the influence of functional groups and sugar composition on their antioxidant capacity. A series of quercetin derivatives were therefore prepared and assessed for their DPPH radical scavenging properties. Isoquercetin O-gallates were more potent radical scavengers than quercetin. The systematic analysis highlights the importance of the distribution of hydroxy substituents in isoquercetin O-gallates to their potency.
Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents
Hossion, Abugafar M. L.,Zamami, Yoshito,Kandahary, Rafiya K.,Tsuchiya, Tomofusa,Ogawa, Wakano,Iwado, Akimasa,Sasaki, Kenji
, p. 3686 - 3703 (2011/08/03)
A structure-guided molecular design approach was used to optimize quercetin diacylglycoside analogues that inhibit bacterial DNA gyrase and topoisomerase IV and show potent antibacterial activity against a wide spectrum of relevant pathogens responsible f
Synthesis and biological evaluation of flavonoids as vasorelaxant agents
Chen, Zhiwei,Hu, Yongzhou,Wu, Haohao,Jiang, Huidi
, p. 3949 - 3952 (2007/10/03)
Several 5,7-dihydroxyflavone and quercetin 3-O-glycosides have been synthesized and evaluated for vasorelaxant activity. A logP-activity relationship amongst flavonoids was suggested.