16588-24-2

Basic information

• Product Name: 5-BROMO-2-CHLORONITROBENZENE
• Synonyms: 4-BROMO-1-CHLORO-2-NITROBENZENE;5-BROMO-2-CHLORONITROBENZENE;Benzene, 4-broMo-1-chloro-2-nitro-
• CAS NO: 16588-24-2
• Molecular Formula: C₆H₃BrClNO₂
• Molecular Weight: 236.45
• Mol File: 16588-24-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.827 g/cm³
• Vapor Pressure: 0.00689mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 5-BROMO-2-CHLORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLORONITROBENZENE(16588-24-2)
• EPA Substance Registry System: 5-BROMO-2-CHLORONITROBENZENE(16588-24-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 16588-24-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-chloronitrobenzene is a chemical compound with the molecular formula C6H3BrClNO2. It is a derivative of nitrobenzene with a bromine and chlorine substituent. 5-BROMO-2-CHLORONITROBENZENE is a yellow solid that is sparingly soluble in water but soluble in organic solvents. It is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. 5-Bromo-2-chloronitrobenzene is also used as a building block in the production of other chemicals and is handled and stored with care due to its potential hazardous properties.

InChI:InChI=1/C6H3BrClNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 106-39-8 bromochlorobenzene 
• 7697-37-2 nitric acid 
• 4771-47-5 3-chloro-2-nitro-benzoic acid 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 108-90-7 chlorobenzene 
• 635-22-3 4-Chloro-3-nitroaniline 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 875-51-4 4-Bromo-2-nitroaniline 

Downstream Products

• 4871-39-0 2-[(4-bromo-2-nitrophenyl)thio]-2-methylpropanoic acid 
• 15327-48-7 5-bromo-2-chloroaniline hydrochloride 
• 76209-05-7 4,4′-dibromo-2,2′-dinitrodiphenyl disulfide 
• 60811-17-8 5-bromo-2-chloroaniline 
• 875-51-4 4-Bromo-2-nitroaniline 
• 56966-61-1 5-bromo-2--phenoxynitrobenzene 
• 59504-32-4 1-(4-Bromo-2-nitro-phenyl)-pyrrolidine 
• 5465-66-7 5-bromo-2-piperidin-1-yl-nitrobenzene 
• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 913836-26-7 2-(4-Chloro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 823-57-4 2-bromo-5-chloroaniline 
• 305372-56-9 5-bromo-2-phenylbenzo[d]thiazole 

Relevant articles and documents

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Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1): and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer.