16671-86-6

Basic information

• Product Name: Benzoic acid, 2-thiocyanato-
• CAS NO: 16671-86-6
• Molecular Formula: C8H5NO2S
• Molecular Weight: 179.199
• Mol File: 16671-86-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-thiocyanato-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-thiocyanato-(16671-86-6)
• EPA Substance Registry System: Benzoic acid, 2-thiocyanato-(16671-86-6)

Safety Data

• Hazardous Substances Data: 16671-86-6(Hazardous Substances Data)

Upstream product

• 7732-18-5 water 
• 333-20-0 potassium thioacyanate 
• 143-33-9 sodium cyanide 
• 66304-00-5 1-oxo-1H-1λ⁴-benzo[1,2]dithiol-3-one 
• 325750-33-2 2-acetoxyimino-benzo[b]thiophen-3-one 

Downstream Products

• 4892-02-8 Methyl thiosalicylate 
• 3724-10-5 2-(methylthio)benzoic acid 
• 147-93-3 Thiosalicylic acid 
• 100058-70-6 Ethyl 2-(ethylthio)benzoate 
• 21101-79-1 2-ethylsulfanylbenzoic acid 
• 1879-21-6 methyl 2-thiocyanatobenzoate 
• 10512-65-9 4H-2,3-dihydro-1,3-benzothiazine-2,4-dione 
• 25802-88-4 benzo[e][1,3]thiazine-2,4-dione 2-(toluene-4-sulfonylhydrazone) 
• 3844-31-3 trans-thioindigo 
• 191031-07-9 3-hydroxy-benzo[b]thiophene-2-carboxylic acid 
• 6287-88-3 methyl 2-[(2-methoxy-2-oxoethyl)thio]benzoate 
• 135-13-7 (o-carboxyphenyl)thioacetic acid 
• 13134-76-4 methyl 3-hydroxybenzo[b]thiophene-2-carboxylate 
• 130-03-0 thioindoxyl 

Relevant articles and documents

DNA Alkylation by leinamycin can be triggered by cyanide and phosphines

Previous work has shown that alkylation of DNA by the antitumor agent leinamycin (1) is potentiated by reaction of the antibiotic with thiols. Here, it is shown that other soft nucleophiles such as cyanide and phosphines can also trigger DNA alkylation by leinamycin. Overall, the results suggest that reactions of cyanide and phosphines with leinamycin produce the oxathiolanone intermediate (2), which is known to undergo rearrangement to the DNA-alkylating episulfonium ion 4.