183208-36-8

Basic information

• Product Name: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE;5-METHOXY-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine,5-methoxy-(9CI);1H-Pyrrolo[2,3-b]pyridine, 5-methoxy-;5-Metho×y-1H-pyrrolo[2,3-b]pyridine;5-Methoxyl-7-azaindole;5-METHOXY-1H-PYRROLO[2,3-B]PYR;5-methoxy-1H-pyrrolopyridine
• CAS NO: 183208-36-8
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Product Categories: PYRIDINE;Azaindoles
• Mol File: 183208-36-8.mol

Chemical Properties

• Boiling Point: 412.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.24
• Refractive Index: 1.647
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.24±0.20(Predicted)
• CAS DataBase Reference: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE(183208-36-8)
• EPA Substance Registry System: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE(183208-36-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 183208-36-8(Hazardous Substances Data)

Usage

Chemical Properties

Tan solid

InChI:InChI=1/C8H8N2O/c1-11-7-4-6-2-3-9-8(6)10-5-7/h2-5H,1H3,(H,9,10)

Upstream product

• 67-56-1 methanol 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 124-41-4 sodium methylate 
• 271-63-6 7-Azaindole 
• 183208-34-6 5-bromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one 
• 183208-32-4 3,3,5-Tribromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one 
• 754214-54-5 5-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-pyrrolo[2,3-b]pyridine 
• 10592-27-5 7-azaindoline 
• 1101060-84-7 2-amino-3-methyl-5-methoxypyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 
• 1826-67-1 vinyl magnesium bromide 
• 126739-64-8 3-methoxy-6-nitropyridine 
• 52092-47-4 5-chloro-2-nitropyridine 

Downstream Products

• 183208-38-0 3-formyl-5-methoxy-1H-pyrrolo<2,3-b>pyridine 
• 916895-89-1 7-azaserotonin 
• 737003-45-1 5-hydroxy-1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1198277-95-0 5-methoxy-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312017-98-3 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclohexyl-ethanol 
• 1312018-13-5 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-ethanol 
• 1312018-29-3 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-furan-2-yl)-ethanol 
• 1312019-37-6 (1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol 
• 397842-89-6 5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1312018-03-3 2-[2-cyclohexyl-1(R)-(4-methanesulfonyl-phenyl)-ethyl]-5-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 1312016-12-8 2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 1312016-13-9 2-{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yloxy}-N,N-dimethyl-acetamide 
• 1312016-16-2 2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-b]pyridine 
• 1312016-20-8 (2-{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yloxy}-ethyl)-dimethyl-amine 

Relevant articles and documents

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The invention discloses 5 -hydroxy- 7 7-azaindole preparation method, which takes 5 - X - 2 -nitropyridine as a raw material to react with benzyl alcohol sodium or sodium alkyl sodium alkoxide to generate 5 - R - 2 -nitropyridine, which is benzyl, methyl or ethyl X after being closed by a Grignard reagent ring after cyclization is carried, out, and ;R is high, yield. (by machine translation)

5-methoxy-7-azaindole synthesis method

The invention relates to a 5-methoxy-7-azaindole synthesis method, and provides a 5-methoxy-7-azaindole synthesis method, which comprises: a) preparing a compound 2 by using a compound 1 as a raw material; and b) preparing 5-methoxy-7-azaindole from the compound 2. Compared with the method in the prior art, the synthesis method of the present invention greatly shortens the synthesis route, effectively avoids the by-products in the prior art, and has increased total yield.

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