19419-23-9Relevant articles and documents
Diastereoselective and Reversed Regioselective Annulations of N-Alkyl Anilines to Julolidines and Lilolidines
Jana, Chandan K.,Mandal, Sumana,Saha, Subhajit
, (2020)
A three-component annulation reaction of N-alkyl anilines, cyclic 1,3-dicarbonyl compounds, and aryl aldehydes to julolidines and lilolidines is reported. The 6π-electrocyclization enabled the annulation to proceed with reversed regioselectivity as compar
Rapid Chemical Reaction Monitoring by Digital Microfluidics-NMR: Proof of Principle Towards an Automated Synthetic Discovery Platform
Wu, Bing,von der Ecken, Sebastian,Swyer, Ian,Li, Chunliang,Jenne, Amy,Vincent, Franck,Schmidig, Daniel,Kuehn, Till,Beck, Armin,Busse, Falko,Stronks, Henry,Soong, Ronald,Wheeler, Aaron R.,Simpson, André
, p. 15372 - 15376 (2019)
Microcoil nuclear magnetic resonance (NMR) has been interfaced with digital microfluidics (DMF) and is applied to monitor organic reactions in organic solvents as a proof of concept. DMF permits droplets to be moved and mixed inside the NMR spectrometer t
Synthesis, characterization, and electrochemistry of some acridine-1,8-dione dyes
Srividya,Ramamurthy,Shanmugasundaram,Ramakrishnan
, p. 5083 - 5089 (1996)
The synthesis, characterization, and electrochemical behavior of some acridinedione derivatives are reported. Cyclic voltammetric studies show that all the dyes undergo irreversible oxidation irrespective of the substitution on the nitrogen. The product formed on oxidation is the aromatic derivative in the case of N-H compounds and the acridinium salt in the case of the N-substituted compounds, which have been isolated and characterized. Formation of an intermediate carbon-centered radical is observed as evidenced by ESR spin-trapping experiments. A mechanistic scheme for the electrochemical oxidation is proposed. On carrying out reduction after oxidation, different products are formed depending on the substitution on the nitrogen. There is no reduction of the oxidized product in the case of N-H compounds, and compounds with substitution on nitrogen undergo reduction consistent with the observation in N-alkylpyridinium salts.
Tetraketones: A new class of tyrosinase inhibitors
Khan, Khalid Mohammed,Maharvi, Ghulam Murtaza,Khan, Mahmud Tareq Hassan,Jabbar Shaikh, Ahson,Perveen, Shahnaz,Begum, Saeedan,Choudhary, Mohammad Iqbal
, p. 344 - 351 (2006)
Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 μM), 11 (IC50 = 2.09 μM), 15 (IC 50 = 2.61 μM), and 27 (ICsu
Application of SiO 2 nanoparticles as an efficient catalyst to develop syntheses of perimidines and tetraketones
Alinezhad, Heshmatollah,Ahmadi, Armin,Hajiabbasi, Parvin
, (2019/04/10)
Abstract: In this paper, we explore the catalytic activity of SiO 2 nanoparticles (NPs) as an eco-friendly, efficient and reusable catalyst in the synthesis of 2,3-dihydro-1H-perimidines as well as tetraketones. For tetraketones syntheses, a si
Merging supramolecular catalysis and aminocatalysis: Amino-appended β-cyclodextrins (ACDs) as efficient and recyclable supramolecular catalysts for the synthesis of tetraketones
Ren, Yufeng,Yang, Bo,Liao, Xiali
, p. 22034 - 22042 (2016/03/08)
Well-designed amino-appended β-cyclodextrins (ACDs) with an amino side chain of different lengths at the primary face of β-CD were synthesized and employed in the catalytic synthesis of a series of tetraketones as supramolecular catalysts in water for the first time. Yields of 58-97% were obtained with up to 30 examples of substrate. The catalyst could be recycled easily, while a 92% yield and 84% rate of catalyst recovery could be achieved after 8 cycles of catalyst recycling. Moreover, a catalytic mechanism merging supramolecular catalysis and aminocatalysis could be proposed through detailed 1D and 2D NMR, ESI-MS and Job plot analyses. This protocol retained the promising characteristics of ambient temperature, green medium, simple operation, broad substrate scope, excellent yields, superb catalyst recycling performance and unique catalytic mechanism.
A four-ketone derivative and its preparation method and application
-
Paragraph 0024; 0025; 0026, (2016/10/10)
The invention provides tetrone derivatives as well as a preparation method and application thereof. The derivatives have a general formula structure shown in the specification, wherein in the structure, R1 is any one of -H, 4-OCH3, 2-Cl, 3,4-(OCH3)2, 4-CH
L-Proline-catalysed the synthesis of aromatic aldehydes and ketones and their acridione derivatives at room temperature
Wang, Fang-Ming,Bao, Dan,Hu, Bing-Xiang,Zhou, Ze-Yu,Huang, Deng-Deng,Chen, Li-Zhuang,Liu, Yang-Mei
, p. 445 - 450 (2015/11/03)
A series of xanthene derivatives were prepared from cyclohexane-1,3-dione and aromatic aldehydes through Knoevenagel-Michael and cyclisation reactions in methanol:ethanol mixture (1:1), catalysed by a very small amount of l-proline at room temperature. Is
Aldonitrones as aldehyde equivalents: An efficient, green, and novel protocol for the synthesis of 1,8-dioxo-octahydroxanthenes
Kumar, Dhruva,Suresh,Sandhu, Jagir S.
, p. 2739 - 2747 (2013/08/23)
A novel, self-catalyzed, solvent-free, microwave-enhanced, green, and efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes and bis-5,5-dimethyl-1,3-cyclohexanediones by condensing aldo-nitrones (imine oxide) and dimedone (5,5-dimethyl-1,3-
A green and highly efficient protocol for catalyst-free Knoevenagel condensation and Michael addition of aromatic aldehydes with 1,3-cyclic diketones in PEG-400
Firouzeh, Nemati,Hossein, Kiani
experimental part, p. 2407 - 2410 (2012/02/04)
A convenient, highly efficient and green approach for synthesis of tetraketones from aromatic aldehydes with dimedone and 1,3-indanedione at room temperature in PEG-400 is described. The use of PEG-400 as the reaction medium and avoiding the use of any ca
