1956-11-2

Basic information

• Product Name: 4-NITROPHENYL LAURATE
• Synonyms: LAURIC ACID 4-NITROPHENYL ESTER;4-NITROPHENYL LAURATE;P-NITROPHENYL LAURATE;Dodecanoic acid 4-nitrophenyl ester~4-Nitrophenyl dodecanoate;P-NitrophenylLaurateA.R.;4-NITROPHENYL LAURATE 98%;4-Nitrophenyl laurate, Dodecanoic acid 4-nitrophenyl ester;Dodecanoic acid p-nitrophenyl ester
• CAS NO: 1956-11-2
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.41
• EINECS: 217-796-2
• Mol File: 1956-11-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: ~46 °C
• Boiling Point: 432.6°Cat760mmHg
• Flash Point: 154.9°C
• Appearance: /
• Density: 1.057g/cm³
• Vapor Pressure: 1.09E-07mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: 2-8°C
• Solubility: almost transparency in hot Methanol
• BRN: 1889084
• CAS DataBase Reference: 4-NITROPHENYL LAURATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROPHENYL LAURATE(1956-11-2)
• EPA Substance Registry System: 4-NITROPHENYL LAURATE(1956-11-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 1956-11-2(Hazardous Substances Data)

Usage

Uses

4-Nitrophenyl Laurate is Lauric Acid derivative displaying inhibitory activity against gram-positive and/or gram-negative organisms.

InChI:InChI=1/C18H27NO4/c1-2-3-4-5-6-7-8-9-10-11-18(20)23-17-14-12-16(13-15-17)19(21)22/h12-15H,2-11H2,1H3

Upstream product

• 143-07-7 lauric acid 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 100-02-7 4-nitro-phenol 
• 112-52-7 1-chlorododecane 
• 658-78-6 1-nitro-4-trifluoroacetoxy-benzene 
• 112-16-3 dodecanoyl chloride 
• 112-16-3 n-dodecanoyl chloride 

Downstream Products

• 80289-35-6 lauroylsalicylaldoxime 
• 100-02-7 4-nitro-phenol 
• 64-19-7 acetic acid 
• 629-25-4 Sodium laurate 
• 824-78-2 4-nitrophenol sodium salt 
• 503840-07-1 (1S,2R,3R)-dodecanoic acid (2,3-dihydroxy-1-hydroxymethyl-3-phenyl-propyl)-amide 
• 69943-69-7 N-octyldodecanamide 
• 22205-13-6 N-decyldodecanamide 
• 143-07-7 lauric acid 
• 4228-00-6 lauric acid phenyl ester 
• 106-33-2 ethyl laurate 
• 3681-78-5 n-propyl laurate 
• 106-18-3 butyl laurate 
• 34316-64-8 lauric acid hexyl ester 

Relevant articles and documents

FUNCTIONAL FLUOROCARBON MICELLES. PHASE SEPARATION AND REACTIVITY CHANGE OF HYDROXAMATE NUCLEOPHILES IN MIXED MICELLES OF HYDROCARBON AND FLUOROCARBON SURFACTANTS

The titration behavior of long-chain(hydrocarbon and fluorocarbon) hydroxamic acids in the presence and absence of micellar matrices is influenced by phase separation of hydrocarbon and fluorocarbon species.The same factors operate in the hydrolysis of phenyl esters.

A domino Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines and application to the synthesis of the ceramide transport inhibitor (±)-HPA-12

A Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines with primary and secondary amines has been developed which affords 4-hydroxy-3-aminoketones. The aza-Michael products were reduced using non-selective NaBH4/MeOH or diastereoselective (up to 92:8) SnCl4/NaBH4 conditions yielding (1R?,3S?)-3-amino-1,4-diols in up to 97% and 70% yield respectively. The major reduction product was converted in two steps to (±)-HPA-12, which is an inhibitor of the cytosolic ceramide transporting protein.

Dodecanoic acid derivatives: Synthesis, antimicrobial evaluation and development of one-target and multi-target QSAR models

In this study a series of dodecanoic acid derivatives (1-30) were synthesized and evaluated for in vitro antimicrobial activity against the panel of Gram positive, Gram negative bacterial and fungal strains. 4-Nitro phenyl dodecanoate (4) and quinolin-8-yl dodecanoate (5) emerged as most effective antibacterial agents, and 1-(4-benzylpiperazin- 1-yl) dodecan-1-one (15) was found to be the most effective antifungal agent amongst the synthesized dodecanoic acid derivatives. Quantitative structure activity relationship (QSAR) studies performed by the development of one-target and multi-target models indicated that multitarget model was effective in describing the antimicrobial activity of dodecanoic acid derivatives as well demonstrated the importance of topological parameter, zero-order molecular connectivity index (0X). Springer Science+Business Media, LLC 2010.