21103-33-3

Basic information

• Product Name: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE
• Synonyms: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE;1-(4-aMino-1-butyl)-4-(2-Methoxyphenyl)piperazine;1-(4-Aminobutyl)-4-(2-methoxyphenyl)piperazine;4-[4-(2-Methoxyphenyl)-1-piperazinyl]butylamine
• CAS NO: 21103-33-3
• Molecular Formula: C₁₅H₂₅N₃O
• Molecular Weight: 263.3785
• Mol File: 21103-33-3.mol

Chemical Properties

• Boiling Point: 405.501°C at 760 mmHg
• Flash Point: 199.04°C
• Appearance: /
• Density: 1.049g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE(21103-33-3)
• EPA Substance Registry System: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE(21103-33-3)

Safety Data

• Hazard Codes: C
• Statements: 34-52
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735PSN1 8 / PGII
• Hazardous Substances Data: 21103-33-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H25N3O/c1-19-15-7-3-2-6-14(15)18-12-10-17(11-13-18)9-5-4-8-16/h2-3,6-7H,4-5,8-13,16H2,1H3

Upstream product

• 102392-05-2 2-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-isoindole-1,3-dione 
• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 1221408-65-6 4-(4-(2-methoxyphenyl)piperazin-1-yl)butan-1-amine hydrochloride 
• 25024-99-1 4‐[4‐(2‐methoxyphenyl)piperazin‐1‐yl]butannitrile 

Downstream Products

• 134390-72-0 4-[4-(1-adamantanecarboxamido)butyl]-1-(2-methoxyphenyl)piperazine 
• 115338-28-8 N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzamide 
• 134390-69-5 Pentanoic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide 
• 134390-68-4 1-(2-methoxyphenyl)-4-<4-(4-phenytlbutyramido)butyl>piperazine 
• 114222-46-7 4,4a,5,5a,6,6a-hexahydro-2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]4,6-ethenocycloprop[f]isoindole-1,3(2H,3AH)-dione 
• 134390-76-4 4-<4-<4-(benzyloxy)benzamido>butyl>-1-(methoxyphenyl)piperazine 
• 130475-74-0 3-<4-<4-(2-methoxyphenyl)piperazin-1-yl>butyl>thieno<3,4-d>pyrimidine-2,4-dione 

Relevant articles and documents

Preparation, characterization, and screening of a high affinity organometallic probe for α-adrenergic receptors

Figure Presented. An organometallic rhenium complex having high and selective affinity for α-adrenergic receptors is reported. A series of methoxyphenylpiperazinecarborane ligands complexed to the [Re(CO) 3]+ core were prepared and t

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Owing to their multifunctional pharmacological profiles (including dual 5-HT1A/5-HT7 action), arylpiperazine derivatives are widely used for treating central nervous system diseases including the depression or neuropathic pain. Herein we describe the design, synthesis and evaluation of biological activity of novel 5-HT7 ligands derived of 2,4,6-triamino-1,3,5-triazine. The studied compounds showed affinity and high selectively towards 5-HT7 receptor with the two most active compounds 34 (Ki = 61 nM), 22 (Ki = 109 nM) showing good metabolic stability and moderate affinity to CYP3A4 isoenzyme. Compound 22 had high hepatotoxicity at a concentration below 50 μM, while compound 34 showed low hepatotoxicity even at a concentration above 50 μM.

Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands

Dopamine is an important neurotransmitter in the human brain and its altered concentrations can lead to various neurological diseases. We studied the binding of novel compounds at the dopamine D2 (D2R) and D3 (D3/sub

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Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D4 Receptor Agonists with High Subtype Selectivity

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Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a identified a series of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide D3 ligands. Members of this class are highly selective for D3 versus D2, and we have identified two compounds (13g and 13r) whose rat in vivo IV pharmacokinetic properties that indicate that they are suitable for assessment in in vivo efficacy models of substance use disorders.

Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides

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Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase

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Visible-Light-Mediated Synthesis of Amides from Aldehydes and Amines via in Situ Acid Chloride Formation

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