2210-25-5Relevant articles and documents
A ritter-type reaction over H-ZSM-5: Synthesis of N-isopropylacrylamide from acrylonitrile and isopropyl alcohol
Chen, Xin,Okuhara, Toshio
, p. 194 - 201 (2002)
Catalytic synthesis of N-isopropylacrylamide from acrylonitrile and isopropyl alcohol has been studied using a variety of solid acids in a solid-liquid reaction system at 423 K. Among typical solid and liquid acids, H-ZSM-5 exhibited an exceptionally high catalytic activity. The activity (per gram) of H-ZSM-5 increased as the Al-content (100Al/(Si + Al)%) increased and then decreased through a maximum at an Al content of 2.63%. The specific activity per one acid site, which was estimated from the initial rate and the acid amount, increased greatly as the Al content decreased, which resembles those of the hydrophobicity and the acid strength. The superiority of H-ZSM-5 activity over other strong and hydrophobic solid acids suggests the importance of the unique pore structure. While H-ZSM-5 deactivated severely during the reaction, the catalytic activities were mostly recovered by calcination at 773 K in air. IR spectroscopy and adsorption measurements revealed that the deactivation of H-ZSM-5 was mainly caused by the formation of a polymer of acrylonitrile on the catalyst surface blocking the micropores, but not limiting desorption of the product from the micropores.
Reactivity of secondary N-alkyl acrylamides in Morita–Baylis–Hillman reactions
Ahmar, Mohammed,Queneau, Yves,Verrier, Charlie,Yue, Xiaoyang
, p. 319 - 330 (2021/10/29)
The Morita–Baylis–Hillman (MBH) reaction of secondary N-alkyl acrylamides, discarded up to now from investigations of the scope of activated alkenes, was studied. Optimization of the reaction conditions revealed that a balance must be found between activation of the MBH coupling reaction and that of the undesired competitive aldehyde Cannizzaro reaction. Using 3-Hydroxyquinuclidine (3-HQD) in a 1:1 water-2-MeTHF mixture provides the appropriate conditions that were applicable to a wide range of diversely substituted secondary N-alkyl acrylamides and aromatic aldehydes, giving rise to novel amide-containing MBH adducts under mild and clean conditions.
Synthesis process of N-isopropylacrylamide
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Paragraph 0023, (2018/04/01)
The invention relates to a synthesis process of N-isopropylacrylamide, and belongs to the technical field of new materials. According to the process, acrylonitrile and isopropanol have an alkylation reaction under the catalyzing of tetra-n-butylammonium chloride and sulphuric acid to prepare the N-isopropylacrylamide, an organic layer is separated after the N-isopropylacrylamide is neutralized through ammonium hydroxide, then the N-isopropylacrylamide is extracted through water, an extraction liquid is directly cooled and crystalized after being concentrated to obtain an N-isopropylacrylamide crystal, and the N-isopropylacrylamide crystal is dried in vacuum to obtain a product. The used raw materials are cheap and easy to get, the cost is low, the product purity is high, the yield is high, and the process flow is short. The synthesis process has a broad application prospect in the large-scale production of the N-isopropylacrylamide in a workshop.