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2,4-difluoro-3-methoxybenzoyl chloride is a chemical compound characterized by the molecular formula C8H6ClFO2. It is a benzoyl chloride derivative featuring two fluorine atoms and a methoxy group attached to the phenyl ring, which endows it with unique reactivity and properties in chemical synthesis.

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  • 221221-11-0 Structure
  • Basic information

    1. Product Name: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE
    2. Synonyms: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE
    3. CAS NO:221221-11-0
    4. Molecular Formula: C8H5ClF2O2
    5. Molecular Weight: 206.57
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 221221-11-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(221221-11-0)
    11. EPA Substance Registry System: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(221221-11-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 221221-11-0(Hazardous Substances Data)

221221-11-0 Usage

Uses

Used in Organic Synthesis:
2,4-difluoro-3-methoxybenzoyl chloride is utilized as a versatile reagent for the introduction of the benzoyl group in various chemical reactions. Its presence of fluorine and methoxy groups allows for specific reactivity and selectivity in organic synthesis processes.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2,4-difluoro-3-methoxybenzoyl chloride is employed as a key intermediate in the synthesis of certain drugs. Its unique structure contributes to the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 2,4-difluoro-3-methoxybenzoyl chloride serves as an important building block in the creation of new pesticides and other agrochemicals, leveraging its reactivity to form novel active ingredients.
Safety Considerations:
Due to its high reactivity, 2,4-difluoro-3-methoxybenzoyl chloride should be handled with caution. It has the potential to cause irritation, corrosion, and toxicity upon contact with skin, eyes, and mucous membranes, necessitating proper safety measures during its use in laboratories and industrial settings.

Check Digit Verification of cas no

The CAS Registry Mumber 221221-11-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,2,2 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 221221-11:
(8*2)+(7*2)+(6*1)+(5*2)+(4*2)+(3*1)+(2*1)+(1*1)=60
60 % 10 = 0
So 221221-11-0 is a valid CAS Registry Number.

221221-11-0Relevant articles and documents

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

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, (2017/01/26)

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

Abuhaie, Cristina-Maria,B?cu, Elena,Rigo, Beno?t,Gautret, Philippe,Belei, Dalila,Farce, Amaury,Dubois, Jo?lle,Ghinet, Alina

supporting information, p. 147 - 152 (2013/02/23)

A new family of microtubule-targeting agents with a phenothiazine A-ring was synthesized and evaluated for anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against cellular proliferation and tub

8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

-

Page/Page column 65-66, (2010/11/25)

The invention provides compound and salts of Formula (I) and (II), disclosed herein, which includes compounds of Formula (A) and Formula (B) such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R

INTERMEDIATES AND PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE QUINOLONECARBOXYLIC ACID DERIVATIVES

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Page/Page column 12, (2010/11/08)

[Problem] Provision of a commercially advantageous method for producing an intermediate which is important for producing the antibacterial and which has a mother nucleus common to the antibacterial, and intermediates produced by such method. [Means to Sol

Antimicrobial quinolones, their compositions and uses

-

, (2008/06/13)

This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from these compounds having antimicrobial uses.

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