221221-11-0

Basic information

• Product Name: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE
• Synonyms: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE
• CAS NO: 221221-11-0
• Molecular Formula: C₈H₅ClF₂O₂
• Molecular Weight: 206.57
• Mol File: 221221-11-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(221221-11-0)
• EPA Substance Registry System: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(221221-11-0)

Safety Data

• Hazardous Substances Data: 221221-11-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4-difluoro-3-methoxybenzoyl chloride is utilized as a versatile reagent for the introduction of the benzoyl group in various chemical reactions. Its presence of fluorine and methoxy groups allows for specific reactivity and selectivity in organic synthesis processes.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2,4-difluoro-3-methoxybenzoyl chloride is employed as a key intermediate in the synthesis of certain drugs. Its unique structure contributes to the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 2,4-difluoro-3-methoxybenzoyl chloride serves as an important building block in the creation of new pesticides and other agrochemicals, leveraging its reactivity to form novel active ingredients.
Safety Considerations:
Due to its high reactivity, 2,4-difluoro-3-methoxybenzoyl chloride should be handled with caution. It has the potential to cause irritation, corrosion, and toxicity upon contact with skin, eyes, and mucous membranes, necessitating proper safety measures during its use in laboratories and industrial settings.

Upstream product

• 178974-97-5 2,4-difluoro-3-methoxy-benzoic acid 
• 79-37-8 oxalyl dichloride 
• 372-18-9 1,3-Difluorobenzene 
• 162101-25-9 2,6-difluorophenylboronic acid 
• 28177-48-2 2,6-difluorophenol 
• 437-82-1 1,3-difluoro-2-methoxybenzene 

Downstream Products

• 922492-60-2 (Z)-ethyl 3-hydroxy-3-(2,4-difluoro-3-methoxyphenyl)acrylate 
• 1417560-72-5 C₂₀H₁₃F₂NO₂S 
• 221221-13-2 ethyl 2-(2,4-difluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylate 
• 221221-15-4 ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate 
• 221221-16-5 1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid 
• 1361253-26-0 2,4-difluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide 
• 1361252-94-9 2,4-difluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide 

Relevant articles and documents

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.

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