22248-26-6

Basic information

• Product Name: Butanedioic acid, 2-(4-Methoxyphenyl)-, 1,4-diMethyl ester
• Synonyms: Butanedioic acid, 2-(4-Methoxyphenyl)-, 1,4-diMethyl ester;DiMethyl 2-(4-Methoxyphenyl)succinate;methyl 3-acetoxy-2-(4-methoxyphenyl)propanoate
• CAS NO: 22248-26-6
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.26314
• Mol File: 22248-26-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Butanedioic acid, 2-(4-Methoxyphenyl)-, 1,4-diMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic acid, 2-(4-Methoxyphenyl)-, 1,4-diMethyl ester(22248-26-6)
• EPA Substance Registry System: Butanedioic acid, 2-(4-Methoxyphenyl)-, 1,4-diMethyl ester(22248-26-6)

Safety Data

• Hazardous Substances Data: 22248-26-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 637-69-4 4-Methoxystyrene 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 768-60-5 4-methoxyphenylacetylen 
• 106-51-4 p-benzoquinone 
• 624-49-7 dimethylfumarate 
• 74-88-4 methyl iodide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 91266-22-7 (Z)-4-Methoxy-4-(4-methoxy-phenyl)-but-3-enoic acid methyl ester 
• 149-73-5 trimethyl orthoformate 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 22248-24-4 2-(4-methoxyphenyl)ethane-1,1,2-tricarbonitrile 

Downstream Products

• 136705-25-4 (4-hydroxy-phenyl)-succinic acid dimethyl ester 
• 488713-71-9 2-[5'-aminomethyl-5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid 
• 488713-52-6 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid 
• 488713-41-3 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid 
• 883993-75-7 2-[5'-cyano-5-formyl-6,2'-bis-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester 
• 488713-67-3 2-[3-formyl-4-(2-methoxy-ethoxymethoxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-phenyl]-succinic acid dimethyl ester 
• 878673-54-2 2-[3-bromo-5-formyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester 
• 488713-18-4 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-succinic acid dimethyl ester 
• 488713-20-8 2-(3-formyl-4-hydroxy-phenyl)-succinic acid dimethyl ester 
• 23053-35-2 2-(4'-hydroxyphenyl)butane-1,4-dioic acid 

Relevant articles and documents

Ni-Catalyzed Reductive C-O Bond Arylation of Oxalates Derived from α-Hydroxy Esters with Aryl Halides

A Ni-catalyzed reductive cross-coupling of α-hydroxycarbonyl compounds modified with oxalyl groups and aryl halides has been developed that furnishes α-aryl esters under mild conditions and tolerates a variety of functionalized aryl halides bearing electron-withdrawing and -donating groups. This work highlights C-O bond fragmentation on secondary alkyl carbon centers that generates α-carbonyl radicals.

Co-catalysis over a bi-functional ligand-based Pd-catalyst for tandem bis-alkoxycarbonylation of terminal alkynes

A bi-functional ligand (L1) containing a diphosphino fragment and sulfonic acid group (-SO3H) enabled PdCl2(MeCN)2 to efficiently catalyze the tandem bis-alkoxycarbonylation of terminal alkynes to produce aryl-/alkyl-substituted succinate (α,ω-diesters). It was found that the -SO3H incorporated in L1 indispensably assisted the Pd-catalyst in accomplishing this tandem reaction via intramolecular synergic effects. Co-catalysis over the L1-based Pd-catalyst was not due to the physical mixture of Xantphos and MeSO3H. In situ FTIR analysis verified that the formation and stability of Pd-H active species were facilitated by the presence of L1. The formation of stabilized diacylpalladium intermediate (F) was the critical driving force for the second-step methoxycarbonylation. DFT calculation was carried out to optimize the geometric structure of F, which indicated that the developed intramolecular O?H hydrogen bonds were an important structural feature to stabilize F. In addition, the L1-based Pd-catalyst could be recycled successfully for at least 3 runs in the ionic liquid [Bmim]NTf2 without obvious activity loss and detectable metal leaching.

Selective aryl α-diimine/palladium-catalyzed bis-alkoxycarbonylation of olefins for the synthesis of substituted succinic diesters

Aryl α-diimine derivatives have been used, for the first time, as efficient new ligands for the palladium-catalyzed oxidative bis-alkoxycarbonylation reaction of olefins. The most active catalyst was formed in situ from bis(9-anthryl)-2,3-dimethyl-1,4-dia