Dimethyl 2-(4-methoxyphenyl)succinate

Base Information

• Chemical Name: Dimethyl 2-(4-methoxyphenyl)succinate
• CAS No.: 22248-26-6
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID80441134
• Nikkaji Number: J698.956J
• Mol file: 22248-26-6.mol

Synonyms:Dimethyl 2-(4-methoxyphenyl)succinate;22248-26-6;Dimethyl 2-(4-methoxyphenyl)butanedioate;Dimethyl2-(4-methoxyphenyl)succinate;SCHEMBL6390486;DTXSID80441134;JCYQYZOIHQQYDQ-UHFFFAOYSA-N;2-(4-Methoxyphenyl)succinic acid dimethyl ester;2-(4-methoxy-phenyl)-succinic acid dimethyl ester;2-(4-Methoxyphenyl)-succinic acid dimethyl ester

Chemical Property of Dimethyl 2-(4-methoxyphenyl)succinate

Chemical Property:

• PSA: 61.83000
• LogP: 1.51490
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 252.09977361
• Heavy Atom Count: 18
• Complexity: 281

Purity/Quality:

99% ^*data from raw suppliers

Dimethyl2-(4-methoxyphenyl)succinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CC(=O)OC)C(=O)OC

Technology Process of Dimethyl 2-(4-methoxyphenyl)succinate

There total 14 articles about Dimethyl 2-(4-methoxyphenyl)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-methoxyphenylacetylen (768-60-5) → 2-(4-methoxy-phenyl)-succinic acid dimethyl ester (22248-26-6)

Guidance literature:

With 1,3-bis(tert-butyl(pyridin-2-yl)phosphanyl)propane; palladium(II) acetylacetonate; toluene-4-sulfonic acid; at 100 ℃; for 20h; under 30003 Torr; chemoselective reaction; Sealed tube;

DOI:10.1021/jacs.8b05852

Reference yield: 88.0%

methanol (67-56-1) + 4-Methoxystyrene (637-69-4,24936-44-5) + carbon monoxide (201230-82-2) + p-benzoquinone (106-51-4) → C18H18O6 + 2-(4-methoxy-phenyl)-succinic acid dimethyl ester (22248-26-6)

Guidance literature:

methanol; p-benzoquinone; With palladium(II) trifluoroacetate; bis(9-anthryl)-2,3-dimethyl-1,4-diazabutadiene; toluene-4-sulfonic acid; In tetrahydrofuran; for 0.166667h; Schlenk technique; Inert atmosphere; Autoclave;

4-Methoxystyrene; carbon monoxide; In tetrahydrofuran; at 20 ℃; for 66h; under 3000.3 Torr; Schlenk technique; Inert atmosphere; Autoclave;

DOI:10.1002/adsc.201400501

Reference yield: 82.0%

methanol (67-56-1) + 4-Methoxystyrene (637-69-4,24936-44-5) + carbon monoxide (201230-82-2) → 2-(4-methoxy-phenyl)-succinic acid dimethyl ester (22248-26-6)

Guidance literature:

With copper(l) iodide; oxygen; triphenylphosphine sulfide; palladium dichloride; for 72h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01637-2

upstream raw materials:

methanol

2-(4-methoxyphenyl)ethane-1,1,2-tricarbonitrile

4-(4-methoxy-phenyl)-4-oxo-butyric acid

trimethyl orthoformate

Downstream raw materials:

(4-hydroxy-phenyl)-succinic acid dimethyl ester

2-[5'-aminomethyl-5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid

2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid

2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid