2302-39-8Relevant articles and documents
Tuning the electronic properties of tetradentate iron-NHC complexes: Towards stable and selective epoxidation catalysts
B?th, Alexander D.,Bernd, Marco A.,Dyckhoff, Florian,Hofmann, Benjamin J.,Kühn, Fritz E.,Oberkofler, Jens,Reich, Robert M.,Schlagintweit, Jonas F.
, p. 548 - 561 (2020)
Two sets of bio-inspired non-heme iron complexes, each comprising of an FeII and FeIII species, bearing 16-membered macrocyclic tetradentate N-heterocyclic carbene ligands are reported. The complexes exhibit trans labile coordination sites, are characterized by means of NMR, ESI-MS, elemental analysis, SC-XRD and cyclic voltammetry and assessed as olefin epoxidation (pre-)catalysts applying H2O2 as oxidant. Sc(OTf)3 and AcOH are evaluated as Lewis and Br?nsted acidic additives, respectively, resulting in partially noticeable improvement in catalytic performance. Hereby, complex 2b shows high stability (TON = 1000 at 20 °C), high temperature tolerance and advances in the more challenging epoxidation of terminal and functionalized olefins. Furthermore, in-depth DFT calculations are conducted to put the catalysts’ structural and electronic features into relation with the catalytic results.
Rational Design, Synthesis and Evaluation of Novel C6-Bicycloalkaneimidazole Containing Imidazo[1,2-b]pyridazines for ASK1 Inhibition
Lee, Yujin,Jang, Jiyoon,Bibi, Maimoona,Duggirala, Krishna Babu,Ji, Sang Hee,Lee, Ji Hun,Ahn, Sunjoo,Song, Jin Sook,Chae, Chong Hak,Kim, Seong Hwan,Lee, Kwangho
, p. 872 - 877 (2021/05/10)
Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family that involves downstream phosphorylation of MAP kinases, c-Jun N-terminal kinases, and p38 MAP kinases. ASK1 inhibitors could possibly be beneficial for ameliorating the development and progression of diseases. Especially, ASK1 has been of interest as one of therapeutic targets for nonalcoholic fatty liver disease as the most common chronic liver diseases including simple steatosis and nonalcoholic steatohepatitis. In this manuscript, novel ASK1 inhibitor lead KTA-29 which has an imidazo[1,2-b]pyridazine core with novel C6-bicycloheptaneimidazole is disclosed. With the novel imidazo[1,2-b]pyridazine core, structure-activity-relationship study for ASK1 potency is described and KTA-29 affinity toward ASK1 with molecular modeling study is explained.
Syntheses of polyalkylated imidazoles
Evjen, Sigvart,Fiksdahl, Anne
supporting information, p. 1392 - 1399 (2017/07/25)
We have developed improved general simple methods for large-scale preparation of polyalkylated imidazoles by improved multicomponent synthesis from commercially available starting materials. A large range of NH- and N-alkyl-polyalkylimidazoles (40 in total, including novel compounds) has been synthesized.
