26452-97-1

Basic information

• Product Name: indan-1-carbonitrile
• Synonyms: indan-1-carbonitrile;2,3-dihydro-1H-indene-1-carbonitrile
• CAS NO: 26452-97-1
• Molecular Formula: C₁₀H₉N
• Molecular Weight: 143.18516
• EINECS: 247-718-2
• Mol File: 26452-97-1.mol

Chemical Properties

• Boiling Point: 289.1 °C at 760 mmHg
• Flash Point: 105.6 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: 2-8°C
• CAS DataBase Reference: indan-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: indan-1-carbonitrile(26452-97-1)
• EPA Substance Registry System: indan-1-carbonitrile(26452-97-1)

Safety Data

• Hazardous Substances Data: 26452-97-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Industry:
Indan-1-carbonitrile is used as an intermediate in the synthesis of various chemicals for its versatile chemical properties, contributing to the development of pharmaceuticals and agrochemicals.
Used in Dye Industry:
Indan-1-carbonitrile is used as a coupling agent for dyes, enhancing the colorfastness and performance of dye products.
Used in Pharmaceutical Synthesis:
Indan-1-carbonitrile is used as a key component in the production of pharmaceuticals, playing a crucial role in the development of new drugs and medications.
Used in Agrochemical Synthesis:
Indan-1-carbonitrile is used in the creation of agrochemicals, contributing to the advancement of agricultural products and solutions.

InChI:InChI=1/C10H9N/c11-7-9-6-5-8-3-1-2-4-10(8)9/h1-4,9H,5-6H2

Upstream product

• 33695-57-7 1-indanecarboxamide 
• 35275-62-8 1-chloroindane 
• 143-33-9 sodium cyanide 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 83-33-0 inden-1-one 
• 19156-10-6 indan-1-carbonyl chloride 
• 106783-39-5 1-chloro-3-phenyl-indan 
• 7677-24-9 trimethylsilyl cyanide 
• 496-11-7 INDANE 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 73424-46-1 N'-(2,3-dihydro-1H-inden-1-ylidene)-4-methylbenzenesulfonohydrazide 
• 333-20-0 potassium thioacyanate 
• 773837-37-9 sodium cyanide 
• 95-13-6 1-indene 

Downstream Products

• 6322-49-2 4-chloro-2-butanone 
• 155932-36-8 indan-1-carbaldehyde 
• 3799-55-1 6-fluorochrysene 
• 145068-22-0 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile 

Relevant articles and documents

π-mediated rearrangements and 1,2-H shifts of indanylcarbenes

Absolute rate constants determined for 1,2-C and 1,2-H migrations of cyclobutyl-, cyclopentyl-, benzocyclobutenyl- and benzocyclopentenyl-(chloro)- or-(acetoxy)-carbenes reveal that 'phenyl' carbon migrations are preferred to alternative 1,2-C shifts due

Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis?

Summary of main observation and conclusion. An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis. This reaction features the use of organic photosensitizer and low-cost 3d metal catalyst, simple and safe operations, and extremely mild conditions. A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks (22 examples, up to 93% yield and 92% ee).

A metal-free direct C (sp3)-H cyanation reaction with cyanobenziodoxolones

A metal-free protocol of direct C(sp3)-H cyanation with cyanobenziodoxolones functioning as both cyanating reagents and oxidants was developed. Unactivated substrates, such as alkanes, ethers and tertiary amines, were thereby transformed to the corresponding nitriles in moderate to high yields. Mechanistic studies indicated that the cyanation proceeded with two potential pathways, which is highly dependent on the substrates: (1) a free radical case for alkanes and ethers and (2) an oxidative case for tertiary amines.

Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the "cN" Source

A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.

Enantioselective nickel-catalyzed hydrocyanation of vinylarenes using chiral phosphine-phosphite ligands and TMS-CN as a source of HCN

Anti-headache chemistry: In the presence of a tailored modular P,P ligand the nickel-catalyzed addition of HCN, generated in situ from TMS-CN, to styrene derivatives proceeds with an unprecedented level of stereocontrol (up to 97 % ee) to give 2-aryl-acetonitriles, for example, the depicted precursor of Ibuprofen. Copyright

Domino synthesis of fluorine-substituted polycyclic aromatic hydrocarbons: 1,1-difluoroallenes as synthetic platforms

Rather crafty: 1,1-Difluoroallenes bearing an aryl group and a cyclopentene moiety undergo indium(III)-catalyzed Friedel-Crafts-type cyclization with subsequent ring expansion and dehydrogenation to afford fluorinated polycyclic aromatic hydrocarbons in high yields. The introduction of an Ar group was effected by in situ halogenation of the intermediary indium species and a subsequent Suzuki-Miyaura reaction. Copyright

Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

Novel 2-imidazoles have been identified as potent partial agonists of the α1A adrenergic receptor, with good selectivity over the α1B, α1D and α2A receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.

Mild cobalt-catalyzed hydrocyanation of olefins with tosyl cyanide

Mild-mannered and well-behaved: A conceptually new hydrocyanation reaction for non-activated olefins provides secondary and tertiary nitriles in good yields under mild conditions. Salient features of this process include broad functional-group tolerance, readily available starting materials, and ease of execution.

INDANE COMPOUNDS AS CCR5 ANTAGONISTS

The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).