2719-14-4

Basic information

• Product Name: N-(4-methyl-3-nitrophenyl)acetamide
• Synonyms: N-(4-methyl-3-nitrophenyl)acetamide;3'-Nitro-4'-methylacetoanilide;3'-Nitro-p-acetotoluidide;N-(3-Nitro-4-methylphenyl)acetamide;N-(4-methyl-3-nitro-phenyl)ethanamide;2-Nitro-4-acetaMidotoluene;NSC 202380;NSC 86673
• CAS NO: 2719-14-4
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• EINECS: 220-319-0
• Product Categories: Aromatics
• Mol File: 2719-14-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 100-100.5°C
• Boiling Point: 370°Cat760mmHg
• Flash Point: 177.6°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.21±0.70(Predicted)
• CAS DataBase Reference: N-(4-methyl-3-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methyl-3-nitrophenyl)acetamide(2719-14-4)
• EPA Substance Registry System: N-(4-methyl-3-nitrophenyl)acetamide(2719-14-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2719-14-4(Hazardous Substances Data)

Usage

Chemical Properties

Orange Crystalline Solid

Uses

3-Methyl-4-nitro-N-acetylbenzeneamine (cas# 2719-14-4) is a compound useful in organic synthesis.

InChI:InChI=1/C9H10N2O3/c1-6-3-4-8(10-7(2)12)5-9(6)11(13)14/h3-5H,1-2H3,(H,10,12)

Upstream product

• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 103-89-9 4-Methylacetanilide 
• 347909-29-9 N-(4-methyl-3-nitro-phenyl)-N'-phenyl-thiourea 
• 7732-18-5 water 
• 108-24-7 acetic anhydride 
• 6629-29-4 2,4-diamino-6-dinitrotoluene 
• 119-32-4 4-Methyl-3-nitroanilin 
• 75-05-8 acetonitrile 
• 7142-91-8 4-acetylamino-2,6-dinitrotoluene 
• 121-14-2 2,4-dinitrotoluene 
• 64-19-7 acetic acid 
• 112842-34-9 4-N-acetylamino-2-amino-6-nitrotoluene 
• 452291-15-5 C₉H₁₀N₂O₃ 

Downstream Products

• 56185-24-1 4-methyl-3-nitro-diacetanilide 
• 1606159-07-2 C₁₁H₁₁N₃O₂S 
• 43134-76-5 1-amino-3-acetylamino-6-carboxy-benzene 
• 1606159-31-2 C₂₁H₂₂N₄O₃ 
• 21573-29-5 4-acetylamino-2-nitrobenzoic acid 
• 601-87-6 3-methyl-2-nitroaniline 
• 610-25-3 2,4,5-trinitrotoluene 
• 602-29-9 2,3,4-trinitrotoluene 
• 109565-24-4 (5-amino-2-methyl-phenyl)-(4-dimethylamino-phenyl)-diazene 
• 602-01-7 1-methyl-2,3-dinitrobenzene 
• 84228-46-6 4-amino-2-nitrobenzoic acid ethyl ester 
• 56433-00-2 3-chloro-2-nitrobenzyl bromide 
• 5367-26-0 3-chloro-2-nitrotoluene 
• 160088-65-3 4'-methyl-2',3'-dinitroacetanilide 

Relevant articles and documents

Aryl imidazole derivative and application thereof

The invention relates to an aryl imidazole derivative and application thereof. The aryl imidazole derivative is a compound shown as a formula (I) in the description or pharmaceutically acceptable salt thereof. The invention also discloses application of the aryl imidazole derivative in preparation of drugs for treating cancers. The invention further discloses application of the aryl imidazole derivative in preparation of drugs for treating diseases caused by EGFR mutation.

Selective N-acetylation of aromatic amines using acetonitrile as acylating agent

A method for N-acetylation of amines has been developed using acetonitrile as an acylating agent and in situ generated trimethylsilyl iodide as the catalyst under microwave heating condition. The reaction is selective toward aromatic amines while aliphatic amines remain intact. The process eliminates the requirement of toxic acylating reagents like acetic anhydride and acetyl chloride.

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.