Welcome to LookChem.com Sign In|Join Free

CAS

  • or
Thiazole is a heterocyclic compound containing a five-membered ring with sulfur and nitrogen heteroatoms, C3SNH3. It is a colorless volatile liquid with a foul odor and has a green, sweet, nutty, tomato note. Thiazole resembles pyridine in its reactions and is found in various natural sources such as roasted chicken, chicken fat, boiled and cooked beef, grilled and roasted beef, pork liver, beer, cognac, grape brandy, rum, coffee, roasted barley, roasted filbert, roasted peanut, soybean, popcorn, oat products, rice bran, buckwheat, malt, wort, dried bonito, crab, crayfish, and Chinese quince.

288-47-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 288-47-1 Structure
  • Basic information

    1. Product Name: Thiazole
    2. Synonyms: 1,3-THIAZOLE;FEMA 3615;FEMA NUMBER 3615;THIAZOLE;Thiazole,98%;THIAZOLE 99+%;THIAN-4-ONEOXIME
    3. CAS NO:288-47-1
    4. Molecular Formula: C3H3NS
    5. Molecular Weight: 85.12762
    6. EINECS: 206-021-3
    7. Product Categories: C3 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Thiazoles, Isothiazoles &Benzothiazoles;Thiazole;Building Blocks;Halogenated;Organohalides;Thiazoles, Isothiazoles & Benzothiazoles;Alphabetical Listings;Flavors and Fragrances;Q-Z;Building Blocks;Heterocyclic Building Blocks;Thiazoles
    8. Mol File: 288-47-1.mol
  • Chemical Properties

    1. Melting Point: -33°C
    2. Boiling Point: 117-118 °C(lit.)
    3. Flash Point: 72 °F
    4. Appearance: Clear colorless to yellow/Liquid
    5. Density: 1.2 g/mL at 25 °C(lit.)
    6. Vapor Pressure: 21.6mmHg at 25°C
    7. Refractive Index: n20/D 1.538(lit.)
    8. Storage Temp.: Flammables area
    9. Solubility: N/A
    10. PKA: 2.44(at 20℃)
    11. Water Solubility: slightly soluble
    12. Sensitive: Air & Light Sensitive
    13. Stability: Stable. Incompatible with strong oxidizing agents.
    14. Merck: 14,9307
    15. BRN: 103852
    16. CAS DataBase Reference: Thiazole(CAS DataBase Reference)
    17. NIST Chemistry Reference: Thiazole(288-47-1)
    18. EPA Substance Registry System: Thiazole(288-47-1)
  • Safety Data

    1. Hazard Codes: Xn,F
    2. Statements: 10-22-37/38-41
    3. Safety Statements: 16-26-39
    4. RIDADR: UN 1993 3/PG 3
    5. WGK Germany: 3
    6. RTECS: XJ1290000
    7. F: 8-10-23
    8. TSCA: T
    9. HazardClass: 3
    10. PackingGroup: II
    11. Hazardous Substances Data: 288-47-1(Hazardous Substances Data)

288-47-1 Usage

Uses

1. Flavoring Agent and Dye Preparation:
Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It provides a unique flavor and aroma to various products, enhancing their sensory qualities.
2. Vitamin Thiamine (B1) Component:
Thiazole serves as a component of the vitamin thiamine (B1), which is essential for various metabolic processes in the human body.
3. Protected Formyl Group in Natural Product Synthesis:
Thiazole acts as a protected formyl group used in natural product synthesis, allowing for the development of complex organic compounds with specific functional groups.
4. Organometallic Complex Preparation:
Thiazole reacts with alkyl lithium and Grignard's reagent to prepare organometallic complexes, which are important intermediates in organic synthesis.
5. Electrophilic and Nucleophilic Aromatic Substitution:
Thiazole is involved in electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions, respectively, allowing for the functionalization of the thiazole ring in various chemical reactions.
6. Alkylation and Catalyst in Organic Reactions:
Thiazole undergoes alkylation to form thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation, important organic reactions for the synthesis of complex molecules.
7. Preparation of Alagebrium:
Thiazole is also involved in the preparation of alagebrium, a compound with potential therapeutic applications.
8. Recognition Motifs for Metal Ions:
Thiazoles are used to create novel recognition motifs for interaction with divalent and trivalent metal ions in siderophores or antibiotics, which can have applications in the development of new drugs and therapies.
9. Organic Synthesis of Fungicides, Dyes, and Rubber Accelerators:
Thiazole is used in the organic synthesis of fungicides, dyes, and rubber accelerators, contributing to the development of various industrial products.

Air & Water Reactions

Slightly water soluble.

Reactivity Profile

Thioisocyanates, such as Thiazole, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat.

Check Digit Verification of cas no

The CAS Registry Mumber 288-47-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 288-47:
(5*2)+(4*8)+(3*8)+(2*4)+(1*7)=81
81 % 10 = 1
So 288-47-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H3NS/c1-2-5-3-4-1/h1-3H

288-47-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L09970)  Thiazole, 99%   

  • 288-47-1

  • 1g

  • 427.0CNY

  • Detail
  • Alfa Aesar

  • (L09970)  Thiazole, 99%   

  • 288-47-1

  • 5g

  • 1313.0CNY

  • Detail
  • Alfa Aesar

  • (L09970)  Thiazole, 99%   

  • 288-47-1

  • 25g

  • 4492.0CNY

  • Detail
  • Aldrich

  • (151645)  Thiazole  99%

  • 288-47-1

  • 151645-1G

  • 521.82CNY

  • Detail
  • Aldrich

  • (151645)  Thiazole  99%

  • 288-47-1

  • 151645-5G

  • 1,843.92CNY

  • Detail

288-47-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name thiazole

1.2 Other means of identification

Product number -
Other names 1,3-THIAZOLE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:288-47-1 SDS

288-47-1Relevant articles and documents

An Efficient Synthesis of 1,3-Thiazole

Brandsma, L.,Jong, R. L. P. de,VerKruijsse, H. D.

, p. 948 - 949 (1985)

The cyclocondensation of methyl dithiocarbamate with chloroacetaldehyde in aqueous ethanol affords 2-methylthio-1,3-thiazole (82-88percent) which is demethylsulfenylated to 1,3-thiazole (78-81percent) by reaction with lithium in liquid ammonia followed by hydrolysis with aqueous ammonia chloride.

Characteristic flavor formation of thermally processed N-(1-deoxy-α-D-ribulos-1-yl)-glycine: Decisive role of additional amino acids and promotional effect of glyoxal

Zhan, Huan,Cui, Heping,Yu, Junhe,Hayat, Khizar,Wu, Xian,Zhang, Xiaoming,Ho, Chi-Tang

, (2021/09/28)

The role of amino acids and α-dicarbonyls in the flavor formation of Amadori rearrangement product (ARP) during thermal processing was investigated. Comparisons of the volatile compounds and their concentrations when N-(1-deoxy-α-D-ribulos-1-yl)-glycine r

Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis

Hayes, Hannah L. D.,Wei, Ran,Assante, Michele,Geogheghan, Katherine J.,Jin, Na,Tomasi, Simone,Noonan, Gary,Leach, Andrew G.,Lloyd-Jones, Guy C.

supporting information, p. 14814 - 14826 (2021/09/13)

The kinetics and mechanism of the base-catalyzed hydrolysis (ArB(OR)2→ ArB(OH)2) and protodeboronation (ArB(OR)2→ ArH) of a series of boronic esters, encompassing eight different polyols and 10 polyfluoroaryl and heteroaryl moieties, have been investigated by in situ and stopped-flow NMR spectroscopy (19F,1H, and11B), pH-rate dependence, isotope entrainment,2H KIEs, and KS-DFT computations. The study reveals the phenomenological stability of boronic esters under basic aqueous-organic conditions to be highly nuanced. In contrast to common assumption, esterification does not necessarily impart greater stability compared to the corresponding boronic acid. Moreover, hydrolysis of the ester to the boronic acid can be a dominant component of the overall protodeboronation process, augmented by self-, auto-, and oxidative (phenolic) catalysis when the pH is close to the pKaof the boronic acid/ester.

Photocatalytic Generation of 2-Azolyl Radicals: Intermediates for the Azolylation of Arenes and Heteroarenes via C-H Functionalization

Arora, Amandeep,Weaver, Jimmie D.

supporting information, p. 3996 - 3999 (2016/08/30)

The 2-azolyl radical, generated from 2-bromoazoles via photocatalysis, is a powerful intermediate for the intermolecular arylation of unmodified (hetero)arenes. The reaction is characterized by mild conditions, operational simplicity, tolerance toward functional and sterically demanding groups, broad scope, and anti-Minisci selectivity. A working mechanism is provided, and a low-solubility amine is essential for successful coupling. The utility of the reaction is demonstrated via late-stage functionalization of methyl estrone and application toward other bromoarenes.

Reduction of Aryl Halides into Arenes with 2-Propanol Promoted by a Substoichiometric Amount of a tert-Butoxy Radical Source

Ueno, Ryota,Shimizu, Takashi,Shirakawa, Eiji

supporting information, p. 741 - 744 (2016/03/12)

Aryl halides are reduced into the corresponding arenes in high yields, using 2-propanol, cesium carbonate, and di-tert-butyl peroxide (or di-tert-butyl hyponitrite) as a reductant/solvent, a base, and a radical initiator, respectively. This simple system reduces a wide variety of aryl bromides, chlorides, and iodides through single-electron-transfer mechanism with high functional-group tolerance.

Reductive Alkylation of 2-Bromoazoles via Photoinduced Electron Transfer: A Versatile Strategy to Csp2-Csp3 Coupled Products

Arora, Amandeep,Teegardin, Kip A.,Weaver, Jimmie D.

, p. 3722 - 3725 (2015/08/18)

Access to Csp2-Csp3-coupled products is a challenging goal at the forefront of catalysis. The photocatalytic reductive coupling of aryl bromides with unactivated alkenes is introduced as a convenient method that circumvents any need for synthesis of sp3-hybridized coupling partners. The reaction takes place via photoinduced electron transfer from a tertiary amine to an aryl bromide that fragments to provide an aryl radical and subsequently reacts with an alkene to form a C-C bond. Conveniently, the amine also serves as the final reductant. The method is operationally simple, functional group tolerant, and takes place with selectivities that will allow it to be used in the context of complex molecule synthesis.

Rhodium-catalyzed 2-methylthiolation reaction of thiazoles/oxazoles using 2-(methylthio)thiazole

Arisawa, Mieko,Nihei, Yuri,Yamaguchi, Masahiko

, p. 939 - 949 (2015/03/04)

RhH(PPh3)4 and 1,3-bis(dicyclohexyl)phosphinopropane (dcypp) catalyze the 2-methylthiolation of oxazoles and thiazoles using 2-(methylthio)thiazole as a thiolating reagent. The methylthio transfer reaction is under equilibrium, and various 2-methylthiolated thiazoles and oxazoles were obtained in moderate to good yields by removing thiazole under refluxing o-dichlorobenzene.

Photooxygenation of N-(2-thiazolyl)sulfanilamide, 2-(4-thiazolyl) benzimidazole, and thiacetazone

Jain, Shubha,Chourey, Meena,Jetti, Srinivasa Rao

, p. 155 - 157,3 (2020/09/09)

In the present work, photolysis of N-(2-thiozolyl)sulfanilamide, 2-(4-thiazolyl)benzimidazole and thiacetazone in presence of benzophenone as a sensitizer under 125 W UV Lamp has been reported. Structures of the products have been established by spectral and elemental analysis.

Method for Producing Intermediates for the Production of Novel Macrocycles that are Inhibitors of the Proteasomic Degradation of p27, such as Argyrin and Derivatives Thereof, and Uses of Said Macrocycles

-

, (2012/01/12)

The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.

Lipopeptide Compounds and Their Use

-

, (2011/10/04)

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for convenience, collectively referred to herein as “LP compounds”), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 288-47-1