29866-54-4

Basic information

• Product Name: 2-CHLORO-6-METHOXY-BENZALDEHYDE
• Synonyms: 2-CHLORO-6-METHOXY-BENZALDEHYDE
• CAS NO: 29866-54-4
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Mol File: 29866-54-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 56-58 °C
• Boiling Point: 263.089 °C at 760 mmHg
• Flash Point: 117.142 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-CHLORO-6-METHOXY-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHOXY-BENZALDEHYDE(29866-54-4)
• EPA Substance Registry System: 2-CHLORO-6-METHOXY-BENZALDEHYDE(29866-54-4)

Safety Data

• Hazardous Substances Data: 29866-54-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-methoxy-benzaldehyde is a chemical compound that falls into the category of aromatic aldehydes. Its molecular formula is C8H7ClO2, indicating that it is composed of eight carbon atoms, seven hydrogen atoms, one chlorine atom, and two oxygen atoms. 2-CHLORO-6-METHOXY-BENZALDEHYDE is an organic substance known for its role in the synthesis of other chemical substances. The presence of the benzaldehyde group makes it a crucial base in developing pharmaceuticals, fragrances, and other specialty chemicals. Depending on the synthesis process, this compound may present varying degrees of toxicity, but it's generally imperative to handle it with care.

InChI:InChI=1/C8H7ClO2/c1-11-8-4-2-3-7(9)6(8)5-10/h2-5H,1H3

Upstream product

• 108-43-0 3-monochlorophenol 
• 67-56-1 methanol 
• 89-98-5 2-chloro-benzaldehyde 
• 54166-96-0 methyl 2-amino-6-methoxybenzoate 
• 936479-46-8 methyl 6-chloro-2-methoxybenzoate 
• 18362-30-6 2-chloro-6-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 1038726-89-4 2-chloro-6-methoxyphenylmethanol 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 3260-87-5 3-chloro-o-cresol 
• 135-02-4 ortho-anisaldehyde 
• 3260-88-6 1-chloro-3-methoxy-2-methylbenzene 

Downstream Products

• 29866-52-2 3-bromo-2-chloro-6-methoxybenzaldehyde 
• 18362-30-6 2-chloro-6-hydroxybenzaldehyde 
• 72403-03-3 2-methoxy-6-chlorophenol 
• 1154740-80-3 6-chloro-2H-chromene-3(4H)-one 
• 1038726-89-4 2-chloro-6-methoxyphenylmethanol 

Relevant articles and documents

Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes

We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.

A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers

Catechol mono-ethers are an important class of phenols. They are found in a number of pharmaceuticals, flavoring agents, perfumes, and are used for the preparation of numerous drugs. Herein, we report a mild meta-selective C–H alkylation of these phenols, which is enabled by a cascade of oxidative dearomatization – radical addition – rearomatization process. The method is compatible with reactive functional groups on the parent arenol, such as olefins and halides. Primary, secondary, and teriary alkyl groups can be used, the source of which is most commonly an alkylborane. This process is operationally simple, does not require heating and generally proceeds in good yields.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.