31139-02-3Relevant articles and documents
Scale-up of a recombinant pig liver esterase-catalyzed desymmetrization of dimethyl cyclohex-4-ene-cis-1,2-dicarboxylate
Suess, Philipp,Illner, Sabine,Von Langermann, Jan,Borchert, Sonja,Bornscheuer, Uwe T.,Wardenga, Rainer,Kragl, Udo
, p. 897 - 903 (2014)
A recombinant isoenzyme of pig liver esterase was used for the highly enantioselective desymmetrization of dimethyl cyclohex-4-ene-cis-1,2- dicarboxylate. The selected recombinant esterase showed a significant advantage in enantioselectivity over the comm
Chemoenzymatic Sequential Multistep One-Pot Reaction for the Synthesis of (1S,2R)-1-(Methoxycarbonyl)cyclohex-4-ene-2-carboxylic Acid with Recombinant Pig Liver Esterase
Süss, Philipp,Borchert, Sonja,Wardenga, Rainer,Hinze, Janine,Illner, Sabine,Von Langermann, Jan,Kragl, Udo,Bornscheuer, Uwe T.
, p. 2034 - 2038 (2015)
In this work, the development of a chemoenzymatic process for the production of (1S,2R)-1-(methoxycarbonyl)cyclohex-4-ene-2-carboxylic acid by ECS-PLE06 (recombinant pig liver esterase) is presented. Herein an optimized esterification protocol, starting f
Simple and highly enantioselective nonenzymatic ring opening of cyclic prochiral anhydrides
Bolm, Carsten,Gerlach, Arne,Dinter, Christian L.
, p. 195 - 196 (1999)
A convenient highly enantioselective methanolysis of cyclic meso- anhydrides only requires one equivalent cinchona alkaloid and low temperature. Both enantiomers can be easily obtained with up to 98% ee by using either quinine or quinidine.
Asymmetric hydrolysis of a meso-diester using pig liver esterase immobilised in hollow fibre ultrafiltration membrane
Sousa, Helena A.,Crespo, Joao G.,Afonso, Carlos A.M.
, p. 929 - 934 (2000)
Pig liver esterase (PLE) was physically immobilised in a polysulphone ultrafiltration hollow fibre membrane reactor and used for the repetitive batch two-phase hydrolysis and separation, on a multigram scale, of the meso-diester dimethyl cis-cycloxex-4-en
Ionic Liquid Gels: Supramolecular Reaction Media for the Alcoholysis of Anhydrides
Rizzo, Carla,Mandoli, Alessandro,Marullo, Salvatore,D'Anna, Francesca
, p. 6356 - 6365 (2019)
The search of new enantioselective catalysts, able to promote synthetically useful organic reactions with high levels of asymmetric induction, should be associated with the attention to the suitable reaction medium able to achieve the best efficiency in c
Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis of meso-cyclic anhydrides
Xu, Lingjun,Han, Shuwen,Yan, Linjie,Wang, Haifeng,Peng, Haihui,Chen, Fener
, p. 309 - 317 (2018/02/19)
A family of novel chloramphenicol base-amide organocatalysts possessing a NH functionality at C-1 position as monodentate hydrogen bond donor were developed and evaluated for enantioselective organocatalytic alcoholysis of meso-cyclic anhydrides. These structural diversified organocatalysts were found to induce high enantioselectivity in alcoholysis of anhydrides and was successfully applied to the asymmetric synthesis of (S)-GABOB.
Reversible Switching and Recycling of Adaptable Organic Microgel Catalysts (Microgelzymes) for Asymmetric Organocatalytic Desymmetrization
Borrmann, Ruediger,Palchyk, Volodymyr,Pich, Andrij,Rueping, Magnus
, p. 7991 - 7996 (2018/09/18)
Adaptable enzyme-mimetic catalysts based on temperature-responsive polymer microgels (microgelzymes) have been developed. By a simple change in the temperature, a microgel catalyst can be reversibly switched into its soluble or precipitated form, thus com