33901-46-1

Basic information

• Product Name: 4-NITROPHENOXYACETONITRILE
• Synonyms: 4-NITROPHENOXYACETONITRILE;BUTTPARK 48\04-12;4-Nitrophenoxyacetonitrile,97%;2-(4-nitrophenoxy)acetonitrile;2-(4-nitrophenoxy)ethanenitrile
• CAS NO: 33901-46-1
• Molecular Formula: C₈H₆N₂O₃
• Molecular Weight: 178.14
• Mol File: 33901-46-1.mol

Chemical Properties

• Melting Point: 74-76°C
• Boiling Point: 363.9 °C at 760 mmHg
• Flash Point: 173.9 °C
• Appearance: /
• Density: 1.317g/cm³
• Vapor Pressure: 1.75E-05mmHg at 25°C
• Refractive Index: 1.564
• BRN: 2557915
• CAS DataBase Reference: 4-NITROPHENOXYACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROPHENOXYACETONITRILE(33901-46-1)
• EPA Substance Registry System: 4-NITROPHENOXYACETONITRILE(33901-46-1)

Safety Data

• Statements: 20/22
• Safety Statements: 22-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 33901-46-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-NITROPHENOXYACETONITRILE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 4-NITROPHENOXYACETONITRILE is utilized as an intermediate for the production of pesticides and other agrochemicals. Its involvement in the synthesis of these compounds helps to improve crop protection and yield, ensuring food security and agricultural sustainability.
Used in Dye Production:
4-NITROPHENOXYACETONITRILE is employed as a crucial component in the manufacturing process of dyes. Its chemical properties enable the creation of a wide range of colors and hues, catering to the diverse needs of various industries, such as textiles, plastics, and printing.
Used in Organic Synthesis:
As a versatile building block, 4-NITROPHENOXYACETONITRILE is used in organic synthesis for the preparation of various organic compounds. Its reactivity and functional groups make it an essential component in the synthesis of complex organic molecules, driving innovation and development in the field of organic chemistry.

InChI:InChI=1/C8H6N2O3/c9-5-6-13-8-3-1-7(2-4-8)10(11)12/h1-4H,6H2

Upstream product

• 24067-17-2 4-nitrophenylboronic acid 
• 590-17-0 cyanomethyl bromide 
• 100-02-7 4-nitro-phenol 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 94332-37-3 2.2.2-Trichlor-1.1-bis-<(4-nitro-phenoxy)-acetamino>-aethan 
• 243657-68-3 2-(4-nitrophenoxy)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 261363-01-3 Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide 
• 137987-89-4 1-(2,4-dihydroxyphenyl)-2-(4-nitrophenoxy)ethanone 
• 17716-80-2 2-(4-nitrophenoxy)-N-phenylacetamide 
• 63218-14-4 4-nitrophenoxyacetamide 
• 1532534-58-9 1-(2,4-dihydroxy-5-propylphenyl)-2-(4-nitrophenoxy)ethanone 
• 1532534-32-9 1-(2,4-dihydroxy-5-methylphenyl)-2-(4-nitrophenoxy)ethanone 
• 1532534-69-2 1-(5-hexyl-2,4-dihydroxyphenyl)-2-(4-nitrophenoxy)ethanone 
• 618066-20-9 1-(5-ethyl-2,4-dihydroxyphenyl)-2-(4-nitrophenoxy)ethanone 
• 169286-84-4 (4-amino-phenoxy)-acetonitrile 

Relevant articles and documents

Synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile

A new and efficient protocol for the synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile has been developed using eco-friendly hydrogen peroxide as oxidant under metal-free conditions. This method is compatible with arylboronic acid attached sensitive substituent and obtains desired product in moderate to good yield.

Effect of the tether length upon Truce-Smiles rearrangement reactions

This report examines the effect of substrate design upon the Truce-Smiles rearrangement, an intramolecular nucleophilic aromatic substitution reaction. The length of the molecular spacer that tethers the carbanion nucleophile to the substituted benzene ri