345-29-9Relevant articles and documents
Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids
Luo, Feihua,He, Shuhua,Gou, Quan,Chen, Jinyang,Zhang, mingzhong
, (2021/10/06)
A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.
INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF
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Paragraph 00266, (2019/08/29)
The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.
A Bcl - 2 inhibitor venetoclax and intermediate preparation method (by machine translation)
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Paragraph 0030; 0031; 0033; 0034, (2018/01/11)
The invention relates to a process for preparing Bcl - 2 inhibitor venetoclax required intermediate preparation method, a synthetic route thereof are shown below, in particular comprises the following steps: to compound I 2, 4 - difluoro-benzoic acid as the raw material, and after hydroxy methyl esterification reaction to obtain compound II 4 - fluorosalicylic acid methyl ester, compound II with the piperazine coupling to make the compound III, compound III and IV by the reaction of the raw material compound V, the compound V with compound VI 5 - bromo - 7 - aza indole C - O prepared by coupling compound VII, is intermediate. Preparation method of this invention mild reaction conditions, the operation is simple, environmental protection and high-efficiency and low cost, easy to manufacture on a large scale. (by machine translation)
TRIAZOLE DERIVATIVES AS HSP90 INHIBITORS
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Paragraph 00393; 00407; 00417, (2013/10/21)
A compound of structural formula (I) or (II): as HSP90 inhibitors that possess significantly improved bioavailability over comparative compounds, which are suitable for the treatment of hyperproliferative diseases such as cancer, infections, immune disorders, inflammation, and CNS related disorders.
Sulfoximines: A reusable directing group for chemo-and regioselective ortho C-H oxidation of arenes
Yadav, M. Ramu,Rit, Raja K.,Sahoo, Akhila K.
supporting information; experimental part, p. 5541 - 5545 (2012/06/01)
Sulfoximines direct: A new protocol for the chemo-and regioselective ortho C-H acetoxylation of arenes in N-benzoylated sulfoximines is reported. The sulfoximine directing group is easily detached from the C-H oxidation product through acid-promoted hydrolysis, isolated, and reused (see scheme). The meta-substituted phenols are synthesized following this strategy and the stereointegrity of the sulfoximine is preserved in this transformation. C(sp3)-H acetoxylation of the methyl group is also demonstrated.
PD(II)-CATALYZED HYDROXYLATION OF ARENES WITH O2 OR AIR
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Page/Page column 14, (2011/04/24)
Pd (II) -catalyzed ortho-hydroxylat ion of variously substituted aromatic carboxylic acids under O2 or air is achieved under non-acidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.
Pd(II)-catalyzed hydroxylation of arenes with 1 atm of O2 or air
Zhang, Yang-Hui,Yu, Jin-Quan
supporting information; experimental part, p. 14654 - 14655 (2010/01/06)
(Chemical Equation Presented) Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O2 or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.
AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS
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Page/Page column 44, (2008/06/13)
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
Converting core compounds into building blocks: The concept of regiochemically exhaustive functionalization
Marzi, Elena,Bobbio, Carla,Cottet, Fabrice,Schlosser, Manfred
, p. 2116 - 2123 (2007/10/03)
In a model study, 3-fluorophenol and 3-fluoropyridine were converted into the each time four possible carboxylic acids by passing through the corresponding organometallic intermediates. As an attempt to generalize the findings reveals, a restricted set of principles and methods suffices to cope with all standard scenarios. The most valuable and versatile tools for the regiochemically exhaustive functionalization of a great variety of substrate patterns are the optionally site-selective metalation (either by reagent/substrate matching or by peripheral coordination control), the use of activating or congesting protective groups and the basicity gradient-driven heavy halogen migration (followed by halogen/metal permutation). Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
ANTITHROMBOTIC AROMATIC ETHERS
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Page/Page column 39-40, (2008/06/13)
This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
