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4-Fluoro-2-hydroxybenzoic acid, also known as 4-fluorosalicylic acid, is an organic compound characterized by the presence of a fluorine atom at the 4-position and a hydroxyl group at the 2-position on a benzene ring. It exhibits acidic properties due to the presence of the carboxyl group and is a versatile intermediate in various chemical reactions.
Used in Organic Synthesis:
4-Fluoro-2-hydroxybenzoic acid is used as a key intermediate for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes. Its unique structure allows for selective functionalization and modification, making it a valuable building block in the development of new molecules with desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-fluoro-2-hydroxybenzoic acid is used as a starting material for the production of various drugs and drug candidates. Its ability to be easily modified and incorporated into complex molecular structures makes it an attractive component for the design of new therapeutic agents.
Used in Agrochemical Industry:
4-Fluoro-2-hydroxybenzoic acid is also utilized in the agrochemical industry as a precursor for the synthesis of various pesticides and herbicides. Its chemical properties enable the development of effective and targeted agrochemicals for crop protection and management.
Used in Dye Industry:
In the dye industry, 4-fluoro-2-hydroxybenzoic acid serves as an important intermediate for the production of dyes and pigments. Its unique structure contributes to the color and stability of the resulting dyes, making it a valuable component in the formulation of various colorants for different applications.

345-29-9

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345-29-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 345-29-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 345-29:
(5*3)+(4*4)+(3*5)+(2*2)+(1*9)=59
59 % 10 = 9
So 345-29-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H4F3NO2/c10-9(11,12)4-1-2-6-5(3-4)7(14)8(15)13-6/h1-3H,(H,13,14,15)

345-29-9 Well-known Company Product Price

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  • Alfa Aesar

  • (B24992)  4-Fluorosalicylic acid, 98%   

  • 345-29-9

  • 1g

  • 593.0CNY

  • Detail
  • Alfa Aesar

  • (B24992)  4-Fluorosalicylic acid, 98%   

  • 345-29-9

  • 5g

  • 2161.0CNY

  • Detail
  • Alfa Aesar

  • (B24992)  4-Fluorosalicylic acid, 98%   

  • 345-29-9

  • 25g

  • 8659.0CNY

  • Detail

345-29-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Fluoro-2-hydroxybenzoic acid

1.2 Other means of identification

Product number -
Other names 4-Fluorosalicylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:345-29-9 SDS

345-29-9Relevant articles and documents

Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids

Luo, Feihua,He, Shuhua,Gou, Quan,Chen, Jinyang,Zhang, mingzhong

, (2021/10/06)

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.

INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

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Paragraph 00266, (2019/08/29)

The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

A Bcl - 2 inhibitor venetoclax and intermediate preparation method (by machine translation)

-

Paragraph 0030; 0031; 0033; 0034, (2018/01/11)

The invention relates to a process for preparing Bcl - 2 inhibitor venetoclax required intermediate preparation method, a synthetic route thereof are shown below, in particular comprises the following steps: to compound I 2, 4 - difluoro-benzoic acid as the raw material, and after hydroxy methyl esterification reaction to obtain compound II 4 - fluorosalicylic acid methyl ester, compound II with the piperazine coupling to make the compound III, compound III and IV by the reaction of the raw material compound V, the compound V with compound VI 5 - bromo - 7 - aza indole C - O prepared by coupling compound VII, is intermediate. Preparation method of this invention mild reaction conditions, the operation is simple, environmental protection and high-efficiency and low cost, easy to manufacture on a large scale. (by machine translation)

TRIAZOLE DERIVATIVES AS HSP90 INHIBITORS

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Paragraph 00393; 00407; 00417, (2013/10/21)

A compound of structural formula (I) or (II): as HSP90 inhibitors that possess significantly improved bioavailability over comparative compounds, which are suitable for the treatment of hyperproliferative diseases such as cancer, infections, immune disorders, inflammation, and CNS related disorders.

Sulfoximines: A reusable directing group for chemo-and regioselective ortho C-H oxidation of arenes

Yadav, M. Ramu,Rit, Raja K.,Sahoo, Akhila K.

supporting information; experimental part, p. 5541 - 5545 (2012/06/01)

Sulfoximines direct: A new protocol for the chemo-and regioselective ortho C-H acetoxylation of arenes in N-benzoylated sulfoximines is reported. The sulfoximine directing group is easily detached from the C-H oxidation product through acid-promoted hydrolysis, isolated, and reused (see scheme). The meta-substituted phenols are synthesized following this strategy and the stereointegrity of the sulfoximine is preserved in this transformation. C(sp3)-H acetoxylation of the methyl group is also demonstrated.

PD(II)-CATALYZED HYDROXYLATION OF ARENES WITH O2 OR AIR

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Page/Page column 14, (2011/04/24)

Pd (II) -catalyzed ortho-hydroxylat ion of variously substituted aromatic carboxylic acids under O2 or air is achieved under non-acidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.

Pd(II)-catalyzed hydroxylation of arenes with 1 atm of O2 or air

Zhang, Yang-Hui,Yu, Jin-Quan

supporting information; experimental part, p. 14654 - 14655 (2010/01/06)

(Chemical Equation Presented) Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O2 or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.

AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS

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Page/Page column 44, (2008/06/13)

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).

Converting core compounds into building blocks: The concept of regiochemically exhaustive functionalization

Marzi, Elena,Bobbio, Carla,Cottet, Fabrice,Schlosser, Manfred

, p. 2116 - 2123 (2007/10/03)

In a model study, 3-fluorophenol and 3-fluoropyridine were converted into the each time four possible carboxylic acids by passing through the corresponding organometallic intermediates. As an attempt to generalize the findings reveals, a restricted set of principles and methods suffices to cope with all standard scenarios. The most valuable and versatile tools for the regiochemically exhaustive functionalization of a great variety of substrate patterns are the optionally site-selective metalation (either by reagent/substrate matching or by peripheral coordination control), the use of activating or congesting protective groups and the basicity gradient-driven heavy halogen migration (followed by halogen/metal permutation). Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

ANTITHROMBOTIC AROMATIC ETHERS

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Page/Page column 39-40, (2008/06/13)

This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.

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