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Cas Database

35167-28-3

35167-28-3

Identification

  • Product Name:Benzene, (ethenylseleno)-

  • CAS Number: 35167-28-3

  • EINECS:

  • Molecular Weight:183.112

  • Molecular Formula: C8H8Se

  • HS Code:

  • Mol File:35167-28-3.mol

Synonyms:phenylvinyl selenide;vinylselanyl-benzene;vinyl phenyl selenide;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 16 Articles be found

One-pot synthesis of pyrrolo[2,1-a]isoquinolines via tandem reactions of vinylselenonium salt, 2-bromoethanones, and isoquinoline

Li, Yunxia,Liao, Minghong,Liu, Shanshan,Mao, Deshou,Sun, Qi,Tang, E.,Zhao, Yan

, p. 1563 - 1574 (2020/01/28)

An convenient and one-pot synthesis of pyrrolo[2,1-a]isoquinolines via the tandem reaction of methyl(phenyl)vinylselenonium salt with isoquinoline and 2-bromoethanones has been developed, which features very mild conditions, available substrates, simple experimental procedures, moderate to good yields, and wide functional group tolerance.

MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

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Paragraph 00676; 00679, (2019/03/05)

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

-

Paragraph 00228, (2019/03/05)

The present disclosure provides for compounds of formula (I), wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Synthesis of vinyl thioethers and bis-thioethenes from calcium carbide and disulfides

Rodygin, Konstantin S.,Gyrdymova, Yuliya V.,Zarubaev, Vladimir V.

, p. 476 - 478 (2017/10/05)

Bis-thioethenes and vinyl thioethers were obtained from the reaction of disulfides and calcium carbide in good to high yields using a simple synthetic procedure and common laboratory setup. The tolerance of the reaction was investigated by the examples of aliphatic, aromatic, heteroaromatic and sesquiterpenic substrates.

Enantioselective Synthesis of Quaternary α-Amino Acids Enabled by the Versatility of the Phenylselenonyl Group

Clemenceau, Antonin,Wang, Qian,Zhu, Jieping

, p. 18368 - 18372 (2016/12/16)

A novel Cinchona alkaloid-catalyzed enantioselective conjugate addition of α-alkyl substituted α-nitroacetates to phenyl vinyl selenone was developed. The resulting enantio-enriched α,α-dialkyl substituted α-nitroacetates were subsequently converted to various cyclic and acyclic quaternary α-amino acids, taking advantage of the rich functionalities of the resulting Michael adducts. Novel protocols allowing chemoselective reduction of phenyl selenone to phenyl selenide and reduction of alkyl phenyl selenones to alkanes are also reported.

Process route upstream and downstream products

Process route

phenyl vinyl selenoxide
66030-49-7

phenyl vinyl selenoxide

methyl iodide
74-88-4

methyl iodide

isopropenyl phenylselenide
63017-57-2

isopropenyl phenylselenide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

diphenyl diselenide
1666-13-3

diphenyl diselenide

Conditions
Conditions Yield
Yield given. Multistep reaction. Yields of byproduct given;
With acetic acid; sodium iodide; lithium diisopropyl amide; Product distribution; dependence on time and temperature;
diphenyl diselenide
1666-13-3

diphenyl diselenide

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
In tetrahydrofuran; at 0 ℃;
92%
In tetrahydrofuran; at 0 - 20 ℃;
91%
In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;
In tetrahydrofuran; at 0 - 20 ℃;
In tetrahydrofuran; at 0 - 20 ℃;
Phenylselenyl bromide
34837-55-3

Phenylselenyl bromide

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
In tetrahydrofuran; at 0 - 20 ℃; for 5h;
60%
diphenyl diselenide
1666-13-3

diphenyl diselenide

ethenylmercury chloride
762-55-0

ethenylmercury chloride

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
In benzene; at 35 - 45 ℃; for 2h; Irradiation;
91%
diphenyl diselenide
1666-13-3

diphenyl diselenide

calcium carbide
75-20-7

calcium carbide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

1,2-Diphenylseleno-ethylen
7392-11-2,95391-88-1

1,2-Diphenylseleno-ethylen

Conditions
Conditions Yield
diphenyl diselenide; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;
calcium carbide; With potassium fluoride; In water; dimethyl sulfoxide; at 130 ℃; Overall yield = 63 %; Sealed tube;
Triethoxyvinylsilane
78-08-0

Triethoxyvinylsilane

Phenylselenyl bromide
34837-55-3

Phenylselenyl bromide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
With copper(II) sulfate supported on the solid alumina; potassium carbonate; In tetrahydrofuran; at 70 ℃; for 12h;
78%
Benzeneselenol
645-96-5

Benzeneselenol

calcium carbide
75-20-7

calcium carbide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
With water; potassium hydroxide; In N,N-dimethyl-formamide; at 100 ℃; for 3h; Inert atmosphere; Sealed tube; Green chemistry;
62%
diphenylselenide
1132-39-4

diphenylselenide

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
In tetrahydrofuran; at 0 - 25 ℃; for 12h;
80%
β-(phenylseleno)ethyl chloride
50630-24-5

β-(phenylseleno)ethyl chloride

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
With potassium tert-butylate; In dimethyl sulfoxide; for 3h;
diphenyl diselenide
1666-13-3

diphenyl diselenide

vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: Br2 / tetrahydrofuran
2: 1.) Mg / 1.) THF, reflux, 20 min, 2.) 45 min
With bromine; magnesium; In tetrahydrofuran;

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