35167-28-3Relevant articles and documents
One-pot synthesis of pyrrolo[2,1-a]isoquinolines via tandem reactions of vinylselenonium salt, 2-bromoethanones, and isoquinoline
Li, Yunxia,Liao, Minghong,Liu, Shanshan,Mao, Deshou,Sun, Qi,Tang, E.,Zhao, Yan
, p. 1563 - 1574 (2020/01/28)
An convenient and one-pot synthesis of pyrrolo[2,1-a]isoquinolines via the tandem reaction of methyl(phenyl)vinylselenonium salt with isoquinoline and 2-bromoethanones has been developed, which features very mild conditions, available substrates, simple experimental procedures, moderate to good yields, and wide functional group tolerance.
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
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Paragraph 00228, (2019/03/05)
The present disclosure provides for compounds of formula (I), wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
Enantioselective Synthesis of Quaternary α-Amino Acids Enabled by the Versatility of the Phenylselenonyl Group
Clemenceau, Antonin,Wang, Qian,Zhu, Jieping
, p. 18368 - 18372 (2016/12/16)
A novel Cinchona alkaloid-catalyzed enantioselective conjugate addition of α-alkyl substituted α-nitroacetates to phenyl vinyl selenone was developed. The resulting enantio-enriched α,α-dialkyl substituted α-nitroacetates were subsequently converted to various cyclic and acyclic quaternary α-amino acids, taking advantage of the rich functionalities of the resulting Michael adducts. Novel protocols allowing chemoselective reduction of phenyl selenone to phenyl selenide and reduction of alkyl phenyl selenones to alkanes are also reported.
