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35418-16-7

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35418-16-7 Usage

Uses

tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.As a starting material in the synthesis of radioligands [18F]IUR-1602 and [18F]IUR-1601, applicable for imaging of P2X7R, a therapeutic target for neuroinflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 35418-16-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,4,1 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 35418-16:
(7*3)+(6*5)+(5*4)+(4*1)+(3*8)+(2*1)+(1*6)=107
107 % 10 = 7
So 35418-16-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H15NO3/c1-9(2,3)13-8(12)6-4-5-7(11)10-6/h6H,4-5H2,1-3H3,(H,10,11)/t6-/m0/s1

35418-16-7 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (B4026)  tert-Butyl L-Pyroglutamate  >98.0%(GC)

  • 35418-16-7

  • 1g

  • 380.00CNY

  • Detail
  • TCI America

  • (B4026)  tert-Butyl L-Pyroglutamate  >98.0%(GC)

  • 35418-16-7

  • 5g

  • 1,280.00CNY

  • Detail
  • Aldrich

  • (712957)  tert-Butyl (S)-2-pyrrolidone-5-carboxylate  ≥98% (GC)

  • 35418-16-7

  • 712957-5G

  • 1,884.87CNY

  • Detail

35418-16-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-Pyrrolidone-5-carboxylic acid t-butyl ester

1.2 Other means of identification

Product number -
Other names L-PYROGLUTAMIC ACID TERT-BUTYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35418-16-7 SDS

35418-16-7Relevant articles and documents

Incorporation of cis- and trans -4,5-Difluoromethanoprolines into polypeptides

Kubyshkin, Vladimir S.,Mykhailiuk, Pavel K.,Afonin, Sergii,Ulrich, Anne S.,Komarov, Igor V.

, p. 5254 - 5257 (2012)

Substituted prolines exert diverse effects on the backbone conformation of proteins. Novel difluoro-analogues were obtained by adding difluorocarbene to N-Boc-4,5-dehydroproline methyl ester, which gave the trans-adduct as the sole product with 71% yield. Upon cleavage of the N-protection group the free amino acid decomposed rapidly. Its incorporation into the proline-rich cell-penetrating "sweet arrow peptide" was thus accomplished using a dipeptide strategy. Two building blocks, containing either cis- or trans-4,5-difluoromethanoproline, were obtained by difluorocyclopropanation of the aminoacyl derivatives of 4,5-dehydroproline. The resulting dipeptides were stable under standard conditions of Fmoc solid phase peptide synthesis and, thus, suitable to study conformational effects.

Regioselective reduction of β-enaminoesters

Hussaini, Syed Raziullah,Moloney, Mark G.

, p. 1129 - 1134 (2005)

The regioselective reduction of β-enaminoesters derived from pyroglutamic acid can be readily achieved under mild conditions. Copyright Taylor & Francis, Inc.

Preparation method of (S)-1 - (benzyloxycarbonyl) -5 -oxo-pyrrolidine -2 - formic acid

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Paragraph 0044, (2021/09/01)

The invention discloses a preparation method of (S)-1 - (benzyloxycarbonyl) -5 -oxo-pyrrolidine -2 - formic acid, which mainly solves the complexity in the original process, and is long in period and high in cost. The method specifically comprises first steps of preparing L - benzyloxycarbonyl N - glutamic acid from - L - glutamic acid and a benzyloxycarbonyl donor, second steps of intramolecular condensation cyclization N - benzyloxycarbonyl - L - glutamic acid to obtain the N -benzyloxycarbonyl - L - glutamic acid crude product. The third The crude N - benzyloxycarbonyl - L - glutamic acid crude product and the organic amine base are mixed, and the organic amine salt form is prepared by the solubility of the product in a solvent, fourth (N -) - L - (benzyloxycarbonyl) S oxopyrrolidine -1 - formic acid is prepared by desalinating -5 - benzyloxycarbonyl -2 - glutamic acid. To the method, the high-purity product is prepared, and the yield and the quality are greatly improved.

L-Y-METHYLENEGLUTAMINE COMPOUNDS AND METHODS OF USE

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Paragraph 0082-0084, (2021/02/12)

Disclosed are substantially pure L-y-methyleneglutamine, L-y- methyleneglutamic acid, and/or amide derivatives, and methods of use thereof. In particular, the presently disclosed subject matter relates to L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives thereof, and methods of treating cancer. The method comprises administering one or more substantially pure L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives to a subject in need thereof.

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