3569-99-1

Basic information

• Product Name: 3-Pyridinecarboxylic acid N-hydroxymethylamide
• Synonyms: HYDROXYMETHYLNICOTINAMIDE;BILOCID;3-pyridinecarboxylic acid n-hydroxymethylamide;N-(HYDROXYMETHYL)-3-PYRIDINECARBOXAMIDE;N-(HYDROXYMETHYL)NICOTINAMIDE;bidbilan;bilamid;bilizorin
• CAS NO: 3569-99-1
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: 222-668-4
• Product Categories: Heterocyclic Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Bases & Related Reagents;Heterocycles;Nicotine Derivatives;Nucleotides;API
• Mol File: 3569-99-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 152-154 °C(lit.)
• Boiling Point: 427.7 °C at 760 mmHg
• Flash Point: 212.5 °C
• Appearance: White Solid
• Density: 1.262 g/cm³
• Vapor Pressure: 4.46E-08mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: -20?C Freezer
• Solubility: DMSO, Methanol
• PKA: 12.22±0.46(Predicted)
• Merck: 14,4833
• CAS DataBase Reference: 3-Pyridinecarboxylic acid N-hydroxymethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid N-hydroxymethylamide(3569-99-1)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid N-hydroxymethylamide(3569-99-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: QS4476500
• Hazardous Substances Data: 3569-99-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 3569-99-1 differently. You can refer to the following data:
1. 3-Pyridinecarboxylic acid N-hydroxymethylamide is used as a cholagogue agen.
2. A decomposition
3. A decomposition product found in the preparation of Nicotinic acid.

General Description

A quantitative determination of N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid by thin-layer chromatography-densitometric method has been reported. N-(Hydroxymethyl)nicotinamide is an antimicrobial agent.

InChI:InChI=1/C7H8N2O2/c10-5-9-7(11)6-2-1-3-8-4-6/h1-4,10H,5H2,(H,9,11)

Upstream product

• 50-00-0 formaldehyd 
• 98-92-0 nicotinamide 
• 100-54-9 pyridine-3-carbonitrile 

Downstream Products

• 117554-70-8 11-(Benzamidomethyl)-12-(nicotinamidomethyl)-12H-benzophenothiazine 
• 100-54-9 pyridine-3-carbonitrile 
• 50-00-0 formaldehyd 
• 98-92-0 nicotinamide 
• 264137-20-4 3-{[(pyridine-3-carbonyl)-amino]-methyl}-benzoic acid 
• 1185843-04-2 C₂₁H₁₈N₄O₄ 
• 117554-72-0 11-(Nicotinamidomethyl)-12-(benzamidomethyl)-12H-benzophenothiazine 
• 117554-60-6 N-(2-Phenylamino-naphthalen-1-ylmethyl)-nicotinamide 
• 119871-41-9 N-acetoxymethylnicotinamide 
• 875557-19-0 N-{3-[1-Phenyl-meth-(E)-ylidene-hydrazinocarbonyl]-benzyl}-nicotinamide 
• 875557-13-4 N-(3-hydrazinocarbonyl-benzyl)-nicotinamide 

Relevant articles and documents

3D, 2D and 1D networks via N-H... O and N-H... N hydrogen bonding by the bis-amide analogues: Effect of chain lengths and odd-even spacers

The synthesis, crystal structures and hydrogen bonding networks of four members of the bis(pyridinecarboxamido)alkane and bis(pyridyl)alkanediamides series (1 ≈ n ; 8), where the amide moieties are separated by alkyl chain (-(CH2)n-) having even or odd number of -(CH2)-groups are explored and correlated with the previously reported structures. The odd members (n = odd) of both the series are found to adopt three-dimensional networks in contrast to the 1D or 2D structures of the even members (n = even). This odd-even effect on the dimensionality of the networks however disappears with increase in chain length.

Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones

Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of cone. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo- quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl- benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported.