3678-72-6

Basic information

• Product Name: 4-DIPHENYLMETHYLPYRIDINE
• Synonyms: 4-DIPHENYLMETHYLPYRIDINE;DIPHENYL-4-PYRIDYLMETHANE;4-(diphenylmethyl)-pyridin;4-benzhydrylpyridine;4-(DIPHENYLMETHYL)PYRIDINE HYDROCHLORIDE 99%;Diphenyl-4-pyridylmethane 99%
• CAS NO: 3678-72-6
• Molecular Formula: C₁₈H₁₅N
• Molecular Weight: 245.32
• EINECS: 222-955-4
• Product Categories: Heterocyclic Compounds
• Mol File: 3678-72-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124-126 °C(lit.)
• Boiling Point: 378.2°Cat760mmHg
• Flash Point: 163.8°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.607
• PKA: 5.54±0.10(Predicted)
• CAS DataBase Reference: 4-DIPHENYLMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIPHENYLMETHYLPYRIDINE(3678-72-6)
• EPA Substance Registry System: 4-DIPHENYLMETHYLPYRIDINE(3678-72-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 3678-72-6(Hazardous Substances Data)

Usage

Description

4-DIPHENYLMETHYLPYRIDINE, also known as DPHMP, is a pyridine derivative with the molecular formula C20H17N. It is characterized by a diphenylmethyl group attached to the pyridine ring, resulting in a white to off-white crystalline powder. DPHMP is insoluble in water but readily soluble in organic solvents. This chemical compound is widely recognized for its applications in organic synthesis as a ligand and in the production of pharmaceuticals and agrochemicals. Moreover, it has garnered interest for its potential medicinal uses, such as an anti-inflammatory and antioxidant agent.

Uses

Used in Organic Synthesis:
4-DIPHENYLMETHYLPYRIDINE is used as a ligand in organic synthesis for its ability to facilitate various chemical reactions, enhancing the efficiency and selectivity of the processes involved.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-DIPHENYLMETHYLPYRIDINE is utilized as an intermediate in the synthesis of various drugs, contributing to the development of new medicinal compounds.
Used in Agrochemical Production:
Similarly, in agrochemicals, 4-DIPHENYLMETHYLPYRIDINE serves as an intermediate, playing a crucial role in the creation of substances that protect crops from pests and diseases.
Used in Medicinal Applications:
4-DIPHENYLMETHYLPYRIDINE is studied for its potential as an anti-inflammatory agent, which could be beneficial in treating conditions characterized by inflammation.
4-DIPHENYLMETHYLPYRIDINE is also considered for its antioxidant properties, which may help in protecting cells from damage caused by reactive oxygen species and thus have implications in various therapeutic areas.

InChI:InChI=1/C18H15N/c1-3-7-15(8-4-1)18(16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-14,18H

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 71-43-2 benzene 
• 100-48-1 pyridine-4-carbonitrile 
• 117-34-0 2,2-diphenylacetic acid 
• 63591-86-6 1,3-dioxoisoindolin-2-yl 2,2-diphenylacetate 
• 776-74-9 Bromodiphenylmethane 
• 2116-65-6 4-benzyl pyridine 
• 462-06-6 fluorobenzene 
• 101-81-5 Diphenylmethane 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 10034-85-2 hydrogen iodide 
• 108-90-7 chlorobenzene 
• 29958-05-2 4-(2-chloro-1,1-diphenylethyl)pyridine 
• 119-61-9 benzophenone 

Downstream Products

• 109975-60-2 2,2-diphenyl-2-(4-pyridyl)ethanol 
• 29958-05-2 4-(2-chloro-1,1-diphenylethyl)pyridine 
• 109975-58-8 2-(4-methylphenyl)-1,1-diphenyl-1-(4-pyridyl)ethane 
• 5704-22-3 4-(diphenylmethyl)-1-methylpiperidine 
• 1916-49-0 4-benzhydrylidene-1-methyl-1,4-dihydro-pyridine 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 1522267-99-7 (diphenyl-4-pyridyl-methane)H[trans-RuCl₄(diphenyl-4-pyridyl-methane)] 
• 1353894-17-3 trans-[diphenyl-4-pyridylmethane(+1H)][RuCl₄(dimethylsulfoxide)(diphenyl-4-pyridylmethane)] 
• 1353894-18-4 trans-Na[RuCl₄(dimethylsulfoxide)(diphenyl-4-pyridylmethane)] 
• 1235721-19-3 Se-methyl 4-(diphenylmethylidene)-4H-azine-N-selenocarbamate 
• 26344-73-0 4-(diphenylmethyl)piperidine hydrochloride 
• 42362-54-9 4-(chloro-diphenyl-methyl)-pyridine 
• 19841-73-7 4-(Diphenylmethyl)piperidine 
• 72964-97-7 4-benzhydryl-1-methyl-pyridinium; iodide 

Relevant articles and documents

Metal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidize carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed the decarboxylation smoothly, and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycle tests and gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chemical toolbox.

Nickel-Catalyzed C(sp3)-H Arylation of Diarylmethane Derivatives with Aryl Fluorides

A novel nickel-catalyzed C(sp3)-H arylation with nonactivated aryl fluorides is reported. The use of 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene (IMes) as a ligand was found to be critical to the success of the reaction. This new method enables the synthesis of a wide range of triarylmethane derivatives.

LDA-Mediated Synthesis of Triarylmethanes by Arylation of Diarylmethanes with Fluoroarenes at Room Temperature

A practical and convenient approach for the secondary C(sp3)-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields.