39560-34-4

Basic information

• Product Name: 3-(2-hydroxybenzoyl)propionic acid
• Synonyms: 3-(2-hydroxybenzoyl)propionic acid;2-Hydroxy-γ-oxobenzenebutanoic acid;3-(2-HYDROXYBENZOYL)PROPIONIC ACID(WXG01892);4-(2-Hydroxy-phenyl)-4-oxo-butyric acid
• CAS NO: 39560-34-4
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• EINECS: 254-508-4
• Mol File: 39560-34-4.mol

Chemical Properties

• Boiling Point: 393.8°Cat760mmHg
• Flash Point: 206.1°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 6.6E-07mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 3-(2-hydroxybenzoyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxybenzoyl)propionic acid(39560-34-4)
• EPA Substance Registry System: 3-(2-hydroxybenzoyl)propionic acid(39560-34-4)

Safety Data

• Hazardous Substances Data: 39560-34-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10O4/c11-8-4-2-1-3-7(8)9(12)5-6-10(13)14/h1-4,11H,5-6H2,(H,13,14)

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-95-2 phenol 
• 6311-68-8 monophenyl succinate 
• 15571-99-0 4-Chlorophenyl Hydrogen Succinate 
• 7446-70-0 aluminium trichloride 
• 108-88-3 toluene 
• 56871-93-3 methyl 3-(2-hydroxybenzoyl)-propionate 

Downstream Products

• 35387-19-0 2-hydroxybenzenebutanoic acid 
• 39496-84-9 4-(2-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester 
• 39595-35-2 4-(2-ethoxy-phenyl)-4-oxo-butyric acid 
• 75349-02-9 cholesteryl 3-(o-hydroxybenzoyl)propionate 
• 133414-47-8 10,10a-Dihydro-1H,3H-9-oxa-3,4-diaza-phenanthren-2-one 
• 99046-13-6 4-oxo-4-(2-methoxyphenyl)butyric acid methyl ester 
• 103897-42-3 ethyl 4-(2-methoxyphenyl)-4-oxobutanoate 
• 39606-16-1 3-(o-Propoxybenzoyl)propionic acid 
• 56871-93-3 methyl 3-(2-hydroxybenzoyl)-propionate 
• 39499-60-0 6-(2-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 115386-92-0 1-(2-ethoxy-phenyl)-1,4,4-tris-(2-methoxy-phenyl)-buta-1,3-diene 
• 102172-07-6 5-(2-ethoxy-phenyl)-5-(2-methoxy-phenyl)-dihydro-furan-2-one 
• 103987-16-2 β-methoxy-γ-oxo-γ-phenylbutanoic acid 

Relevant articles and documents

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.

Photochemical Versus Aluminium Chloride-Catalyzed Fries Rearrangement of Aryl Hydrogen Succinates. Synthesis of 2(3H)-Furanones

The photochemical and aluminium chloride-catalyzed Fries rearrangement of a series of aryl hydrogen succinates 3 a-f to the corresponding 4-oxoacids 1 a-f are compared.Both approaches are complementary: the photochemical process is more general and becomes the method of choice for the succinoylation of phenols supporting alkoxy or hydroxy substituents, while the classical rearrangement is superior in the presence of alkyl or halogen substituents.These results are applied to the preparation of the 2(3H)-furanones 2 a-f. - Keywords: Fries rearrangement; Photo-Fries rearrangement; Aryl hydrogen succinates; 4-Oxoacids; 2(3H)-Furanones.