40134-18-7

Basic information

• Product Name: METHYL 2-CHLORONICOTINATE
• Synonyms: METHYL 2-CHLORO-3-PYRIDINECARBOXYLATE;METHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE;METHYL 2-CHLORONICOTINATE;2-CHLORONICOTINIC ACID METHYL ESTER;2-CHLORO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;Methyl 2-chloronicotinate 98%;2-Chloro-3-pyridinecarboxylic acid methyl ester, 2-Chloro-nicotinic acid methyl ester;2-Chloropyridine-3-carboxylic acid methyl ester
• CAS NO: 40134-18-7
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: 254-805-9
• Product Categories: blocks;Carboxes;Pyridines;Pyridine;pharmacetical;pyridine series
• Mol File: 40134-18-7.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 150 °C/1 mmHg
• Flash Point: 110 °C
• Appearance: Colorless/Liquid
• Density: 1.314 g/mL at 25 °C
• Vapor Pressure: 0.0429mmHg at 25°C
• Refractive Index: n 20/D 1.537
• Storage Temp.: Keep Cold
• PKA: -1.39±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-CHLORONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLORONICOTINATE(40134-18-7)
• EPA Substance Registry System: METHYL 2-CHLORONICOTINATE(40134-18-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 40134-18-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloronicotinate is a chemical compound that belongs to the class of nicotinate derivatives. It is a derivative of nicotinic acid, also known as vitamin B3. METHYL 2-CHLORONICOTINATE is widely used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. Methyl 2-chloronicotinate is known for its mild, pleasant odor and it is commonly used as a flavoring agent in the food industry. It is also utilized as an intermediate in the production of agrochemicals, dyes, and other organic compounds. This chemical is considered to have low toxicity and is generally safe for use with proper handling and precautions.

InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 2942-59-8 2-chloronicotinic acid 
• 67-56-1 methanol 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 78948-09-1 acetyl hypofluorite 
• 77-78-1 dimethyl sulfate 
• 96440-05-0 2-chloro-3-ethylpyridine 
• 56880-79-6 3-Ethyl-1-methyl-2-pyridon 
• 74-88-4 methyl iodide 
• 36851-80-6 nitrosomethylurea 
• 63270-91-7 β-dibutylaminoacroleine 
• 105-34-0 methyl 2-cyanoacetate 
• 927-63-9 3-dimethylaminoacrolein 

Downstream Products

• 208983-73-7 2-styrylnicotinic acid methyl ester 
• 210161-08-3 methyl 2-(4-fluorophenyl)nicotinate 
• 16081-87-1 2-phenylpyrido<2,3-d>pyrimidin-4(3H)-one 
• 252921-14-5 methyl 2-(3-nitrophenyl)-3-pyridinecarboxylate 
• 36701-90-3 methyl-2-(3'-α,α,α,-trifluoromethyl-phenoxy)nicotinate 
• 132389-29-8 N-(3-Chlorophenyl)-3-hydroxythieno[2,3-b]pyridine-2-carboxamide 
• 929541-51-5 2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester 
• 33109-14-7 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one 
• 1301225-27-3 C₁₄H₉Cl₂NO₂ 
• 1301225-31-9 2-(4-chlorophenyl)-4H-pyrano[2,3-b]pyridin-4-one 
• 15441-52-8 2-phenyl-4H-pyrano[2,3-b]pyridin-4-one 
• 1301225-26-2 C₁₄H₁₀ClNO₂ 
• 1301225-25-1 C₁₅H₁₂ClNO₂ 
• 924300-01-6 2-p-tolyl-4H-pyrano[2,3-b]pyridin-4-one 

Relevant articles and documents

Preparation method of 2-chloro-N, N-dimethyl nicotinamide

The invention belongs to the technical field of pesticides, and particularly relates to a preparation method of 2-chloro-N, N-dimethyl nicotinamide. The preparation method of the 2-chloro-N, N-dimethyl nicotinamide comprises the following steps of taking 2-chloronicotinic acid as a raw material, and carrying out esterification reaction with methanol to obtain 2-chloronicotinic acid methyl ester, and carrying out aminolysis reaction with dimethylamine in the presence of a catalyst N, N-dimethyl nicotinamide to obtain the 2-chloro-N, N-dimethyl nicotinamide. The preparation method disclosed by the invention is mild and controllable in reaction, simple in process equipment, low in dimethylamine consumption, low in production cost and good in product quality, and the amount of wastewater is greatly reduced and is easy to treat.

A microwave synthesis 2 - halogenated nicotinate and intermediates thereof

The invention discloses a method for synthesizing 2-halogenated nicotinic acid ester and intermediates thereof through microwave method. The method comprises the following steps: adding substitute amino acrolein, a catalyst and cyan-acetic ester into a reactor, carrying out reaction under microwave radiation, and tracking the reaction till substitute amino acrolein disappears to prepare and obtain reaction liquid of the intermediates of 2-halogenated nicotinic acid ester; adding hydrogen halide into the reaction liquid, continuously carrying out reaction, and tracking and monitoring the reaction till the reaction is complete; adding alkali liquor into the reaction liquid to adjust the pH value to 5-6; carrying out standing delamination to obtain an aqueous layer and an organic layer; extracting the aqueous layer with an organic solvent, combining the extracted aqueous layer with the organic layer, and carrying out refinement to prepare and obtain 2-halogenated nicotinic acid ester. The synthesis method of 2-halogenated nicotinic acid ester related to the invention has the advantages of beingenvironment-friendly, short in reaction time, simple to operate, high in product yield and good in quality.

LIBRARIES OF PYRIDINE-CONTAINING MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present disclosure relates to novel pyridine-containing macrocyclic compounds and libraries thereof that are useful as research tools for drug discovery efforts. This disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.