40872-87-5

Basic information

• Product Name: Methyl 3-amino-4-chlorobenzoate
• Synonyms: 3-AMINO-4-CHLOROBENZOIC ACID METHYL ESTER;METHYL 3-AMINO-4-CHLOROBENZOATE;METHYL, 4-CHLORO-3-AMINOBENZOATE;Amino chlorobenzoic acid methyl ester;Methyl 3-Amino-4-chlorobenzene;Benzoic acid, 3-aMino-4-chloro-, Methyl ester;Methyl 3-AMino-4-chlorobenzoate, 98.0%(GC&T;Intedanib Impurity 5
• CAS NO: 40872-87-5
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Esters
• Mol File: 40872-87-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 292.1 °C at 760 mmHg
• Flash Point: 130.4 °C
• Appearance: /
• Density: 1.311 g/cm³
• Vapor Pressure: 0.00188mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Methyl 3-amino-4-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-amino-4-chlorobenzoate(40872-87-5)
• EPA Substance Registry System: Methyl 3-amino-4-chlorobenzoate(40872-87-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 40872-87-5(Hazardous Substances Data)

Usage

General Description

Methyl 3-amino-4-chlorobenzoate, also known as 3-amino-4-chlorobenzoic acid methyl ester, is an organic compound with the molecular formula C8H8ClNO2. It is a chlorinated derivative of benzoic acid and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical is a white crystalline solid with a chlorobenzene-like odor and is soluble in organic solvents. It is also a potential precursor in the production of other important chemicals and has various industrial applications. Additionally, methyl 3-amino-4-chlorobenzoate may have potential biological activities and is being studied for its pharmacological properties.

InChI:InChI=1/C8H8ClNO2/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4H,10H2,1H3

Upstream product

• 2840-28-0 3-amino-4-chloro-benzoic acid 
• 149-73-5 trimethyl orthoformate 
• 74-87-3 methylene chloride 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 67-56-1 methanol 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 

Downstream Products

• 40872-88-6 4-Chloro-3-(4-methyl-benzoylamino)-benzoic acid methyl ester 
• 864714-68-1 4-chloro-3-(5-formyl-furan-2-yl)-benzoic acid methyl ester 
• 1282529-96-7 methyl 3-(8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate 
• 1282529-97-8 methyl 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoate 
• 1282529-98-9 3-(8-bromo-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)-4-chlorobenzoic acid 
• 1282529-99-0 8-bromo-N-(2-chloro-5-(4-methylpiperazine-1-carbonyl)phenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 
• 1282526-16-2 N₂-(2-chloro-5-(4-methylpiperazine-1-carbonyl)phenyl)-N₂,N₈-dimethyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2,8-dicarboxamide 
• 1408000-63-4 C₈H₆ClN₃O₂ 
• 1408000-58-7 C₂₀H₂₀ClF₃N₆O 
• 706791-87-9 4-chloro-3-(4-chlorobutanoylamino)benzoic acid methyl ester 
• 874523-72-5 4-chloro-3-[N'-(3-[1,3]dioxolan-2-yl-phenyl)-ureido]-benzoic acid methyl ester 

Relevant articles and documents

Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead

In our efforts to identify orally bioavailable CGRP receptor antagonists, we previously discovered a novel series of orally available azepinone derivatives that unfortunately also exhibited the unwanted property of potent time-dependent human CYP3A4 inhib

Efficient and recyclable bimetallic Co–Cu catalysts for selective hydrogenation of halogenated nitroarenes

Silica supported N-doped carbon layers encapsulating Co–Cu nanoparticles (Co1Cux@CN/SiO2) were prepared by a one-step impregnation of Co(NO3)2·6H2O, Cu(NO3)2·3H2O, urea and glucose, following in situ carbothermal reduction. Effects of Cu contents on the catalytic performance of the Co1Cux@CN/SiO2 catalysts were investigated for selective hydrogenation of p-chloronitrobenzene to p-chloroaniline. The Co1Cu0.30@CN/SiO2 with Cu/Co molar ratio of 0.30:1 presented much higher activity and stability than the monometallic Co@CN/SiO2 catalyst. The addition of Cu into Co1Cux@CN/SiO2 catalysts had favorable effects on the formation of highly active Co–N sites and N-doped carbon layer. The role of the N-doped carbon layer was to protect the Co from oxidation by air, and the Co1Cu0.30@CN/SiO2 could be reused for at least 12 cycles without decrease in catalytic efficiency. Mechanistic and in situ infrared studies revealed that the interaction effect between the Co and Cu atoms made the surface of Co highly electron rich, which decreased adsorption of halogen groups and resulting in the enhanced selectivity during chemoselective hydrogenation of halogenated nitroarenes for a wide scope of substrates.

BENZAMIDE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER

The present invention is directed to benzamide derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, liver related disorders and viral infections. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, (II) and (III) are defined herein.