4138-35-6

Basic information

• Product Name: 3-AMINO-PROPIONIC ACID METHYL ESTER
• Synonyms: 3-AMINO-PROPIONIC ACID METHYL ESTER;RARECHEM AL BW 0064;3-Aminopropanoic acid methyl ester;βAla-OMe;Methyl 3-aminopropanoate
• CAS NO: 4138-35-6
• Molecular Formula: C₄H₉NO₂
• Molecular Weight: 103.12
• Mol File: 4138-35-6.mol
• Article Data: 34

Chemical Properties

• Melting Point: 103-104 °C
• Boiling Point: 151.8°Cat760mmHg
• Flash Point: 26.5°C
• Appearance: /
• Density: 1.013g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.67±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-PROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-PROPIONIC ACID METHYL ESTER(4138-35-6)
• EPA Substance Registry System: 3-AMINO-PROPIONIC ACID METHYL ESTER(4138-35-6)

Safety Data

• Hazardous Substances Data: 4138-35-6(Hazardous Substances Data)

Usage

General Description

3-Amino-Propionic Acid Methyl Ester is a type of chemical compound. This organic compound is mainly known for its use in the creation of a variety of different types of chemical products and medicines. The structure consists of a methyl ester, which is derived from propionic acid, linked to a single amino group. As an amino acid derivative, it plays a significant role in the field of biochemistry. It appears as a clear liquid and is also known for its corrosive nature. It should be handled with care, as any ingestion or inhalation of it could cause harm to the respiratory system and eyes.

InChI:InChI=1/C4H9NO2/c1-7-4(6)2-3-5/h2-3,5H2,1H3

Upstream product

• 67-56-1 methanol 
• 144202-82-4 6,6'-bis(β-alanylamino)-2,2'-bipyridine 
• 7664-41-7 ammonia 
• 292638-85-8 acrylic acid methyl ester 
• 75-77-4 chloro-trimethyl-silane 
• 107-95-9 3-amino propanoic acid 
• 1252006-11-3 N-[(6-methoxy-2-oxo-2H-benzo[h]benzopyran-4-yl)methyloxycarbonyl]-L-β-alanine methyl ester 
• 42116-55-2 methyl 3-tert-butoxycarbonylaminopropionate 
• 76-05-1 trifluoroacetic acid 
• 593-78-2 methyl hypochlorite 
• 6057-90-5 β-alanine hydrochloride 
• 23574-01-8 3-benzylamino-propionic acid methyl ester 
• 94887-44-2 methyl N-retinylidene-β-aminopropionate hydrochloride 
• 3196-73-4 methyl 3-aminopropanoate hydrochloride 

Downstream Products

• 60247-39-4 methyl 3-(4-nitrobenzamido)propanoate 
• 119852-36-7 N-(phenyl)-N'-[(2-methoxycarbonyl)ethyl]thiouree 
• 116058-79-8 N,N'-bis(2-methoxycarbonylethyl)-p-xylylenediamine 
• 65005-45-0 benzyloxycarbonylalanyl-β-alanine ethyl ester 
• 129742-82-1 Z-Orn(Boc)-β-Ala-OMe 
• 111970-99-1 C₁₂H₁₃N₃O₃ 
• 102650-11-3 N-{3-[(2-naphthalenylmethyl)oxy]benzoyl}-β-alanine methyl ester 
• 102650-14-6 N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester 
• 86458-99-3 3-[2-(2-Oxo-4-phenyl-azetidin-1-yl)-acetylamino]-propionic acid methyl ester 
• 86459-01-0 1,3-Dicyclohexyl-1-[2-(2-oxo-4-phenyl-azetidin-1-yl)-acetyl]-urea 
• 86459-00-9 3-[3-(2-Oxo-4-phenyl-azetidin-1-yl)-propionylamino]-propionic acid methyl ester 
• 86459-02-1 1,3-Dicyclohexyl-1-[3-(2-oxo-4-phenyl-azetidin-1-yl)-propionyl]-urea 
• 86458-94-8 3-[3-(2-Furan-2-yl-4-oxo-azetidin-1-yl)-propionylamino]-propionic acid methyl ester 
• 86458-97-1 1,3-Dicyclohexyl-1-[3-(2-furan-2-yl-4-oxo-azetidin-1-yl)-propionyl]-urea 

Relevant articles and documents

-

-

Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group

Psammaplin A (PsA) is a bromotyrosine disulfide dimer with histone deacetylase (HDAC) inhibition and acts through reduced monomer PsA-SH. We studied the connection of HDAC inhibition, cell growth inhibition, and apoptosis induction of PsA-SH by modifying the -SH group with deletion (6a) or replacement with hydroxamic acid (10b) or benzamide (12g). PsA-SH inhibits HDAC1/2/3 and 6a loses the HDAC inhibition ability. 10b inhibits HDAC1/2/3/6 while 12g shows selective inhibition of HDAC3. PsA-SH and 10b, but neither 6a nor 12g, induce apoptosis in human leukemia HL-60 cells associated with increased acetylation of Histone H3. PsA-SH and 10b inhibit growth of several solid tumor cell lines in vitro and Lewis lung cancer cell growth in vivo. PsA-SH is a simple scaffold for developing selective HDAC inhibitors and induces apoptosis through inhibiting HDAC1/2.

Manufacturing method for 3-(2-chloropropionylamino)propionic acid alkyl ester

A process for the preparation 3 - (2- chloropropionylamino) propionic acid alkyl esters. The process of the present invention uses alkylacrylates differently than those using β - alanine as a starting material. 3 - (2-chloropropionylamino) propionic acid alkyl ester, which is an intermediate of a uracil compound useful as a herbicide, can be obtained in high yield and high purity without the need for a step of producing a β-alanine methyl ester hydrochloride.