42287-90-1Relevant articles and documents
Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein-protein binding
Karlsson, Christoffer,Blom, Magnus,Johansson, Miranda,Jansson, Anna M.,Scifo, Enzo,Karln, Anders,Govender, Thavendran,Gogoll, Adolf
, p. 2612 - 2621 (2015/05/27)
Incorporation of an artificial amino acid 2 with a stilbene chromophore into peptidomimetics with three to nine amino acids yields phototriggerable candidates for inhibition of the binding between the R1 and R2 subunits of the M. tuberculosis ribonucleotide reductase (RNR). Interstrand hydrogen bond probability was used as a guideline for predicting conformational preferences of the photoisomers. Binding of these inhibitors has been rationalized by docking studies with the R1 unit. Significant differences in binding of the photoisomers were observed. For the shorter peptidomimetics, stronger binding of the Z isomer might indicate hydrophobic interactions between the stilbene chromophore and the binding site. This journal is
Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions
Sharma, Anil K.,Subramani, Amutha V.,Gorman, Christopher B.
, p. 389 - 395 (2007/10/03)
Several halo indanones were synthesized from benzyl Meldrum's acid derivatives in two steps. Although several Lewis acids are effective for the Friedel-Crafts ring-closing reaction on more electron-rich arenes, in the case of the electron-deficient arenes this chemistry is not efficient. Here it is reported that chlorosulfonic acid (used as solvent) is an efficient reagent for cyclization of electron-withdrawing arenes. These molecules are potentially useful for subsequent alkylation reactions. The selective alkylation of 5,7-dibromo indanone is demonstrated using Pd-catalyzed Grignard coupling to provide monoalkylated indanone in good yield.
Syntheses of compounds active toward glutamate receptors: II. Synthesis of spiro hydantoins of the indan series
Matveeva,Podrugina,Morozkina,Zefirova,Seregin,Bachurin,Pellicciari,Zefirov
, p. 1769 - 1774 (2007/10/03)
The article describes a general procedure for synthesizing hydantoins of the indan series, which makes it possible to obtain bioisosteric analogs of 1-aminoindan-1,5-dicarboxylic acid, a group I metabotropic glutamate receptor antagonist.
Pyrethrinoid esters carrying an indanyl nucleus and their use as pesticides
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, (2008/06/13)
Pyrenthrinoid esters with an indenyl nucleus having the following structural formula STR1 wherein the substituents are herein defined, have been shown to be useful as pesticides and in pesticidal compositions.
