42465-53-2

Basic information

• Product Name: 2'AMINO-4'-METHOXYACETOPHENONE
• Synonyms: 1-(2-AMINO-4-METHOXYPHENYL)ETHANONE;2-amino-4-methoxyphenylmethylketone;1-(2-aMino-4-Methoxyphenyl)ethan-1-one
• CAS NO: 42465-53-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 42465-53-2.mol
• Article Data: 23

Chemical Properties

• Melting Point: 119-120 °C
• Boiling Point: 315.4 °C at 760 mmHg
• Flash Point: 166 °C
• Appearance: /
• Density: 1.111 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.88±0.10(Predicted)
• CAS DataBase Reference: 2'AMINO-4'-METHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'AMINO-4'-METHOXYACETOPHENONE(42465-53-2)
• EPA Substance Registry System: 2'AMINO-4'-METHOXYACETOPHENONE(42465-53-2)

Safety Data

• Hazardous Substances Data: 42465-53-2(Hazardous Substances Data)

Usage

Uses

1-(2-Amino-4-methoxyphenyl)ethanone is a useful research reagent for the synthesis of benzothiazine derivatives with antiproliferative activity.

InChI:InChI=1/C9H11NO2/c1-6(11)8-4-3-7(12-2)5-9(8)10/h3-5H,10H2,1-2H3

Upstream product

• 536-90-3 m-Anisidine 
• 75-36-5 acetyl chloride 
• 75-05-8 acetonitrile 
• 1438400-28-2 N-(2-acetyl-5-methoxyphenyl)-4-methylbenzenesulfonamide 
• 38487-85-3 4-methoxyanthranilonitrile 
• 75-16-1 methylmagnesium bromide 
• 917-54-4 methyllithium 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 7446-70-0 aluminum (III) chloride 
• 2797-51-5 quinoclamine 
• 10294-34-5 boron trichloride 
• 89691-67-8 1-(2-bromo-4-methoxyphenyl)ethanone 
• 77287-34-4 formamide 
• 923289-59-2 4-isopropylthiazole-2-carbonyl chloride 

Downstream Products

• 300831-04-3 2-isopropylaminothiazole-4-carboxylic acid (2-acetyl-5-methoxyphenyl)amide 
• 630424-32-7 cyclopropanecarboxylic acid (2-acetyl-5-methoxy-phenyl)-amide 
• 630424-41-8 Pyridine-2-carboxylic acid (2-acetyl-5-methoxy-phenyl)-amide 
• 300831-07-6 N-(2-acetyl-5-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 
• 1044756-19-5 C₁₇H₁₅NO₅ 
• 1044756-80-0 C₁₆H₁₆N₂O₃S 
• 1044756-00-4 C₁₉H₂₀N₂O₃ 
• 1108658-79-2 1-(2-amino-4-chloro-5-methoxyphenyl)ethanone 
• 1363508-08-0 2-acetyl-5-methoxybenzonitrile 
• 90347-63-0 1-(2-iodo-4-methoxyphenyl)ethanone 
• 855239-80-4 N-(2-acetyl-5-methoxyphenyl)benzamide 

Relevant articles and documents

Synthesis of Dihydroquinoline-Based Derivatives of Fluorescent Rhodamine Dyes for Nucleic Acid Analysis by a Real-Time Polymerase Chain Reaction

Abstract: An optimized synthesis scheme for the dihydroquinoline-based derivatives of xanthene fluorescent dye has been developed. For the first time, their use as effective fluorophores in hybridization probes for real-time PCR has been demonstrated with the detection on an individual spectral channel.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

A series of azaisoflavone analogs were designed and synthesized and their transactivation activities and binding affinities for ERα and ERβ were investigated. Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively. Molecular modeling study showed putative binding modes of the compound 3a in the active site of ERα and ERβ, which were similar with that of genistein and provided insight of the effect of N-alkyl substitution of azaisoflavones on ERβ activity. Also, a biphasic effect of azaisoflavone analogs on MCF-7 cell growth depending on their concentrations was investigated.