455-19-6

Basic information

• Product Name: 4-(Trifluoromethyl)benzaldehyde
• Synonyms: A,A,A-TRIFLUORO-P-TOLUALDEHYDE;4-(TRIFLUOROMETHYL)BENZALDEHYDE;4'-TRIFLUOROMETHYL BENZALDEHYDE;P-TRIFLUOROMETHYLBENZALDEHYDE;P-(TRIFLUOROMETHYL)-BENZALDHYDE;PTF-BAD;α,α,α-Trifluoro-p-tolualdehyde ;p-(Trifluoromethyl)benzaldehyde 4-(Trifluoromethyl)benzaldehyde
• CAS NO: 455-19-6
• Molecular Formula: C₈H₅F₃O
• Molecular Weight: 174.12
• EINECS: 207-240-7
• Product Categories: Pharmaceutical Intermediates;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Miscellaneous;organofluorine compounds
• Mol File: 455-19-6.mol
• Article Data: 266

Chemical Properties

• Melting Point: 1-2°C
• Boiling Point: 66-67 °C13 mm Hg(lit.)
• Flash Point: 150 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.275 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: n20/D 1.463(lit.)
• Storage Temp.: 2-8°C
• Solubility: 1.5g/l
• Water Solubility: Soluble in water. 1.5 g/L at 20°C
• Sensitive: Air Sensitive
• BRN: 1101680
• CAS DataBase Reference: 4-(Trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethyl)benzaldehyde(455-19-6)
• EPA Substance Registry System: 4-(Trifluoromethyl)benzaldehyde(455-19-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• TSCA: T
• HazardClass: IRRITANT, AIR SENSITIVE
• Hazardous Substances Data: 455-19-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to yellow liquid

Uses

4-(Trifluoromethyl)benzaldehyde is a reactant that has been used in the preparation of N,N''-(Arylmethylene)bisamides with cytotoxic activity as anti cancer agents.

InChI:InChI=1/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H

Upstream product

• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 98-56-6 4-chlorobenzotrifluoride 
• 68-12-2 N,N-dimethyl-formamide 
• 2591-86-8 N-Formylpiperidine 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 201230-82-2 carbon monoxide 
• 455-13-0 4-Iodobenzotrifluoride 
• 66046-34-2 4-(trifluoromethyl)benzaldehyde oxime 
• 93-61-8 N-methyl-N-phenylformamide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 95725-04-5 N,N-diethyl-4-(trifluoromethyl)benzamide 
• 111991-14-1 2-(4-trifluoromethylphenyl)oxirane 
• 1027382-23-5 tert-butyldimethyl[2,2,2-trichloro-1-(4-trifluoromethylphenyl)ethoxy]silane 

Downstream Products

• 122377-18-8 2-[(4-trifluoromethylphenyl)hydroxymethyl]pyridine 
• 144528-16-5 ((E)-2-(4-(trifluoromethyl)styryl))benzo[d]thiazole 
• 127459-98-7 2-[Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-cyclohexanone 
• 127459-98-7 threo-2-[hydroxy(4-trifluoromethylphenyl)methyl]cyclohexan-1-one 
• 130632-08-5 4-methoxy-N-(4-(trifluoromethyl)benzylidene)aniline 
• 136995-02-3 1-(4-Trifluoromethyl-phenyl)-3H-benzo[4,5]imidazo[1,2-c]thiazole 
• 132132-57-1 2-(4-trifluoromethyl)phenylquinoline-4-carboxylic acid 
• 95123-61-8 (2E)-3-(4-trifluoromethylphenyl)prop-2-enal 
• 61637-11-4 3-(4-(trifluoromethyl)phenyl)-1-phenylprop-2-en-1-one 
• 80992-93-4 4-(4-trifluoromethylphenyl)but-3-en-2-one 
• 140885-43-4 1-<4-(Dimethylamino)phenyl>-3-<4-(trifluoromethyl)phenyl>-prop-2-en-1-one 
• 566171-51-5 N-((4-(trifluoromethyl)phenyl)methylidene)methanamine 
• 911101-44-5 N-(4-trifluoromethylbenzylidene)methanamine 
• 100677-27-8 N,N'-bis(4-trifluoromethylbenzylidene)benzene-1,4-diamine. 

Relevant articles and documents

In alkaline media, Fremy's salt oxidizes alkanols by a hydrogen atom transfer mechanism

In aqueous alkali, Fremy's salt (potassium nitrosodisulfonate dimer), homolyses nearly exclusively to the monomer radical anion, nitrosodisulfonate (NDS). In this media, NDS almost quantitatively oxidizes benzyl alcohol (PhCH2OH) to benzaldehyd

Controlled reduction of activated primary and secondary amides into aldehydes with diisobutylaluminum hydride

A practical method is disclosed for the reduction of activated primary and secondary amides into aldehydes using diisobutylaluminum hydride (DIBAL-H) in toluene. A wide range of aryl and alkyl N-Boc, N,N-diBoc and N-tosyl amides were converted into the corresponding aldehydes in good to excellent yields. Reduction susceptible functional groups such as nitro, cyano, alkene and alkyne groups were found to be stable. Broad substrate scope, functional group compatibility and quick conversions are the salient features of this methodology.

Mild oxidation of benzyl alcohols to benzyl aldehydes or ketones catalyzed by visible light

Induced by visible light, mild oxidation condition to prepare benzyl aldehydes or ketones have been developed by using bromotrichloromethane as photochemical oxidant. This method avoids high temperature, pressure and peroxidation with only visible light as the green driving force.