455-19-6

Basic information

• Product Name: 4-(Trifluoromethyl)benzaldehyde
• Synonyms: A,A,A-TRIFLUORO-P-TOLUALDEHYDE;4-(TRIFLUOROMETHYL)BENZALDEHYDE;4'-TRIFLUOROMETHYL BENZALDEHYDE;P-TRIFLUOROMETHYLBENZALDEHYDE;P-(TRIFLUOROMETHYL)-BENZALDHYDE;PTF-BAD;α,α,α-Trifluoro-p-tolualdehyde ;p-(Trifluoromethyl)benzaldehyde 4-(Trifluoromethyl)benzaldehyde
• CAS NO: 455-19-6
• Molecular Formula: C₈H₅F₃O
• Molecular Weight: 174.12
• EINECS: 207-240-7
• Product Categories: Pharmaceutical Intermediates;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Miscellaneous;organofluorine compounds
• Mol File: 455-19-6.mol

Chemical Properties

• Melting Point: 1-2°C
• Boiling Point: 66-67 °C13 mm Hg(lit.)
• Flash Point: 150 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.275 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: n20/D 1.463(lit.)
• Storage Temp.: 2-8°C
• Solubility: 1.5g/l
• Water Solubility: Soluble in water. 1.5 g/L at 20°C
• Sensitive: Air Sensitive
• BRN: 1101680
• CAS DataBase Reference: 4-(Trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethyl)benzaldehyde(455-19-6)
• EPA Substance Registry System: 4-(Trifluoromethyl)benzaldehyde(455-19-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• TSCA: T
• HazardClass: IRRITANT, AIR SENSITIVE
• Hazardous Substances Data: 455-19-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(Trifluoromethyl)benzaldehyde is used as a key reactant for the synthesis of N,N''-(Arylmethylene)bisamides, which possess cytotoxic activity. These compounds are of significant interest in the development of anticancer agents, targeting various types of cancer cells and exhibiting potential therapeutic benefits in cancer treatment.
The trifluoromethyl group in 4-(Trifluoromethyl)benzaldehyde imparts unique chemical and biological properties to the synthesized compounds, enhancing their overall effectiveness as anticancer agents. The aldehyde functional group allows for further chemical modifications and the formation of a wide range of derivatives with diverse applications in the pharmaceutical industry.

InChI:InChI=1/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H

Upstream product

• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 79-46-9 2-nitropropane 
• 141-52-6 sodium ethanolate 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 93-61-8 N-methyl-N-phenylformamide 
• 16939-49-4 (E)-4-(trifluoromethyl)benzaldoxime 
• 115127-52-1 3-chloro-3-(4-trifluoromethylphenyl)diaziridine 
• 201230-82-2 carbon monoxide 
• 146397-87-7 p-(trifluoromethyl)phenyl trifluoromethanesulfonate 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1071965-81-5 [Pd(Br)(p-CF₃C₆H₄CO)(PtBu₃)] 
• 455-13-0 4-Iodobenzotrifluoride 

Downstream Products

• 129422-61-3 2-<1-hydroxy-1-methyl>-4-methylthiazole 
• 99686-09-6 [Hydroxy-(4-trifluoromethyl-phenyl)-methyl]-phosphonothioic acid O,O-diethyl ester 
• 114702-44-2 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 144486-12-4 1-(4-(trifluoromethyl)phenyl)but-3-en-1-ol 
• 103952-75-6 2-(4-(trifluoromethyl)phenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one 
• 27098-14-2 (4R,6R)-4,6-Dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3]dioxane 
• 27098-19-7 rel-(2S,4R,6S)-4,6-dimethyl-2-<4'-(trifluoromethyl)phenyl>-1,3-dioxane 
• 74289-72-8 p-(trifluoromethyl)benzaldehyde dimethyl acetal 
• 85288-54-6 3,3-bis-(2-methyl-2-propenyl)-2,4-pentanedione 
• 106536-25-8 1-[(1E)-3-methylbuta-1,3-dienyl]-4-(trifluoromethyl)benzene 
• 329-24-8 4-trifluoromethyl-N-(4-trifluoromethyl-benzyliden)-aniline 

Relevant articles and documents

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