481-53-8

Basic information

• Product Name: Tangeretin
• Synonyms: 4',5,6,7,8-PENTAMETHOXYFLAVONE;5,6,7,8,4'-PENTAMETHOXYFLAVONE;5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyrone;TANGERETIN;TANGERITIN;2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-on;2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-one;4’,5,6,7,8-pentamethoxy-flavon
• CAS NO: 481-53-8
• Molecular Formula: C₂₀H₂₀O₇
• Molecular Weight: 372.37
• EINECS: 207-570-1
• Product Categories: Flavanols;Natural Plant Extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 481-53-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 153.0 to 157.0 °C
• Boiling Point: 565.3 °C at 760 mmHg
• Flash Point: 248.4 °C
• Appearance: yellow crystalline
• Density: 1.244 g/cm³
• Vapor Pressure: 8.41E-13mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 351695
• CAS DataBase Reference: Tangeretin(CAS DataBase Reference)
• NIST Chemistry Reference: Tangeretin(481-53-8)
• EPA Substance Registry System: Tangeretin(481-53-8)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 45-36-26
• RIDADR: UN 2811
• WGK Germany: 3
• RTECS: DJ3102725
• Hazardous Substances Data: 481-53-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

antineoplastic

Definition

ChEBI: A pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8.

InChI:InChI=1/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3

Upstream product

• 2798-22-3 5,8-dihydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4-benzopyrone 
• 77-78-1 dimethyl sulfate 
• 66074-96-2 5,6,7,8,4'-penta methoxyl-flavanone 
• 169130-15-8 6-hydroxy-4',5,7,8-tetramethoxyflavone 
• 111497-80-4 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(4-methoxyphenyl)-1,3-propanedione 
• 186581-53-3 diazomethane 
• 98755-26-1 8-demethylthymusin 
• 2798-20-1 gardenin B 
• 10176-66-6 nevadensin 
• 36950-98-8 4'-hydroxy-5,6,7,8-tetramethoxy flavone 
• 74-88-4 methyl iodide 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 41929-26-4 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)propenone 
• 93993-77-2 1-(2,5-dihydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)propenone 

Downstream Products

• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 577-26-4 NSC₇₆₉₈₈ 
• 40110-96-1 4'-benzyloxy-5,6,7,8-tetramethoxyflavone 
• 36950-98-8 4'-hydroxy-5,6,7,8-tetramethoxy flavone 
• 40110-95-0 2'-Hydroxy-3'.4'.5'.6'-tetramethoxy-4-benzyloxy-chalkon 
• 6959-55-3 Acetic acid 4-(5,6,7,8-tetramethoxy-4-oxo-4H-chromen-2-yl)-phenyl ester 
• 96344-55-7 2',3',4',5,5',6,7,8-octamethoxyflavanone 
• 93827-77-1 2-hydroxy-2',3,3',4,5,5',6,6'-octamethoxydibenzoylmethane 
• 93827-78-2 2',3',5,5',6,6',7,8-octamethoxyflavone 
• 93827-76-0 2-(2',3',5',6'-tetramethoxybenzoyloxy)-3,4,5,6,-tetramethoxyacetophenone 
• 87402-96-8 2',3',4',5,5',6,7,8,-octamethoxyflavone 
• 94528-62-8 2',3',4',5,6,6',7,8-octamethoxyflavone 
• 2798-20-1 gardenin B 
• 19103-54-9 5-hydroxy-4',6,7-trimethoxyflavone 

Relevant articles and documents

Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

Semisynthesis of polymethoxyflavonoids from naringin and hesperidin

Polymethoxyflavonoids (PMFs) possess important biological activities, notably as anticancer agents. Semisynthesis of a series of PMFs were performed by glycoside hydrolysis, dehydrogenation, bromination, aromatic nucleophilic substitution, O-methylation, dimethyldioxirane oxidation and regioselective demethylation, starting from abundant and inexpensive natural sources naringin and hesperidin. A new synthetic method for selective methylation using CuBr catalysed and microwave-assisted reaction was developed, and the dimethyl dioxirane oxidation of flavones to flavonols was much improved. The new semisynthetic route has the advantages of easy availability of starting materials, simple operation and good yields.