490-64-2

Basic information

• Product Name: 2,4,5-Trimethoxybenzoic acid
• Synonyms: ASARONIC ACID;AKOS BBS-00003744;2,4,5-TRIMETHOXYBENZOIC ACID;RARECHEM AL BO 0322;2,4,5-trimethoxy-benzoicaci;2,4,5-Trimethoxybenzoic;Benzoic acid, 2,4,5-trimethoxy-;2,4,5-Trimethoxybenzoic acid,99%
• CAS NO: 490-64-2
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.2
• EINECS: 207-715-9
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Pharmaceutical raw materials
• Mol File: 490-64-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 143-145 °C(lit.)
• Boiling Point: 300 °C
• Flash Point: 134 °C
• Appearance: white fine crystalline powder
• Density: 1.3006 (rough estimate)
• Vapor Pressure: 0.000513mmHg at 25°C
• Refractive Index: 1.5140 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly)
• PKA: 4.24±0.10(Predicted)
• Water Solubility: SOLUBLE
• CAS DataBase Reference: 2,4,5-Trimethoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-Trimethoxybenzoic acid(490-64-2)
• EPA Substance Registry System: 2,4,5-Trimethoxybenzoic acid(490-64-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 490-64-2(Hazardous Substances Data)

Usage

Chemical Properties

white fine crystalline powder

Uses

Different sources of media describe the Uses of 490-64-2 differently. You can refer to the following data:
1. 2,4,5-Trimethoxybenzoic Acid can be used to alleviate, treat, and prevent inflammatory diseases.
2. 2,4,5-Trimethoxybenzoic acid was used as internal standard during the determination of the various types of hydroxyl groups present in lignins.

InChI:InChI=1/C10H12O5/c1-13-7-5-9(15-3)8(14-2)4-6(7)10(11)12/h4-5H,1-3H3,(H,11,12)/p-1

Upstream product

• 4460-86-0 asaraldehyde 
• 24160-53-0 2,4,5-trimethoxycinnamic acid 
• 38445-02-2 2,4,5-trimethoxyphenylglyoxylic acid 
• 3166-78-7 2-(2,4,5-trimethoxyphenyl)ethylamine hydrochloride 
• 1818-28-6 2',4',5'-trimethoxyacetophenone 
• 4424-79-7 2,4,5-trimethoxybenzamide 
• 7732-18-5 water 
• 494-40-6 asarone 
• 60-29-7 diethyl ether 
• 67-66-3 chloroform 
• 7722-84-1 dihydrogen peroxide 
• 10028-15-6 ozone 
• 14894-74-7 1,2,4-trimethoxy-5-methylbenzene 
• 67-56-1 methanol 

Downstream Products

• 135-77-3 1,2,4-trimethoxy-benzene 
• 14227-14-6 1,2,4-trimethoxy-5-nitrobenzene 
• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 
• 20129-11-7 1-bromo-2,4,5-trimethoxybenzene 
• 64957-88-6 4,4-dimethyl-2-(2,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazole 
• 89075-26-3 2-(2,4,5-Trimethoxy-phenyl)-3H-imidazo[4,5-c]pyridine; hydrochloride 
• 149220-81-5 2,4,5-trimethoxy-N,N-dimethylbenzamide 
• 83813-97-2 2,4,5-trimethoxybenzoic anhydride 
• 124-38-9 carbon dioxide 
• 74-87-3 methylene chloride 
• 129047-45-6 (E)-1-styryl-2,4,5-trimethoxybenzene 
• 649551-93-9 4'-decyl-2-methoxy-2'-(2'',4'',5''-trimethoxy-benzoyloxy)-acetophenone 
• 50879-52-2 2,4,5-trimethoxy-N-phenylbenzamide 
• 4424-79-7 2,4,5-trimethoxybenzamide 

Relevant articles and documents

AN OCTAMETHOXYFLAVONE FROM POGOSTEMON PURPURASCENS

3,5,6,7,8,2',4',5'-octamethoxyflavone has been isolated from the whole plant of Pogostemon purpurascens.Key Word Index-Pogostemon purpurascens; Labiatae; purpurascenin; 3,5,6,7,8,2',4',5'-octamethoxyflavone

Synthesis method of pharmaceutical intermediate 2,4,5-trimethoxybenzoic acid

The invention discloses a synthesis method of a pharmaceutical intermediate 2,4,5-trimethoxybenzoic acid. The synthesis method takes 1,2,4-trimethoxybenzene, DMF (Dimethyl Formamide), phosphoryl chloride, 2,4,5-trimethoxybenzaldehyde, silver nitrate, acetonitrile, hydrogen peroxide, zirconium oxide and MCM-41 as main raw materials, and MCM-41 zeolite powder is subjected to short-chain modificationby adopting tetraethyl orthosilicate TEOS; ultrasonic treatment is carried out on a mixed alkali solution and metal ion frameworks of nickel nitrate and aluminum nitrate are used for replacing to form a unique space three-dimensional framework structure with catalytic activity. According to the synthesis method disclosed by the invention, the disadvantages that products are complicated, the products are difficultly completely purified and the like, caused by drastic oxidization reaction of traditional benzaldehyde, are overcome by an intermediate catalyst, and the intermediate catalyst has anexcellent catalysis effect on synthesis reaction of the 2,4,5-trimethoxybenzoic acid.

Ceric ammonium nitrate catalyzed oxidation of aldehydes and alcohols

A variety of aromatic, aliphatic and conjugated aldehydes and alcohols were transformed to the corresponding carboxylic acids and ketones with a quantitative conversion in high yields with 70% t-BuOOH solution in water in the presence of catalytic amounts of ceric ammonium nitrate [Ce(NH 4)2(NO3)6] (CAN) under room temperature conditions. The scope of our catalytic system is applicable for a wide range of aromatic, conjugated and aliphatic substrates. These aldehydes were converted to the corresponding carboxylic acids in good isolated yields in reasonable times. This method possesses a wide range of capabilities since it can be used with other functional groups which may not tolerate oxidative conditions, involves fairly simple method for work-up, exhibits chemoselectivity and proceeds under ambient conditions. The resulting products are obtained in good yields within reasonable time.

Bismuth(III) oxide catalyzed oxidation of alcohols with tert-butyl hydroperoxide

A variety of aromatic, aliphatic and conjugated alcohols were transformed into the corresponding carboxylic acids and ketones with aq 70% t-BuOOH in the presence of catalytic amounts of bismuth(III) oxide. This method possesses a wide range of capabilities, does not involve cumbersome work-up, exhibits chemoselectivity and proceeds under ambient conditions. The resulting products are obtained in good yields within reasonable time. The overall method is green.