4919-37-3Relevant articles and documents
New secondary metabolites from Allium victorialis
Khan, Sadia,Fatima, Itrat,Hussain Kazmi, Mehdi,Malik, Abdul
, p. 1176 - 1181 (2013)
Allumines A and B (1 and 2, resp.), two new steroidal alkaloids, and a new cyclopentene derivative, 3, were isolated from the CHCl3-soluble fraction of the whole plant of Allium victorialis. Their structures were elucidated by spectroscopic techniques, including 1D- and 2D-NMR spectroscopy. Copyright
Preparation method of propofol and structural analogues of propofol
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Paragraph 0074-0080, (2017/08/28)
The invention relates to a preparation method of propofol and structural analogues of propofol. The preparation method comprises the steps as follows: preparing an intermediate from p-hydroxybenzoic acid and alkyl alcohol as raw materials under the action of a solid acid catalyst, and then preparing a target product by a decarboxylase reaction. The preparation method has the characteristics of being green in synthesis, realizing biotransformation, causing little pollution, producing few by-products and the like, and is suitable for industrial production; the purity of the prepared products such as propofol is 99.6% or higher, which meets various medicinal standards.
A recyclable nanoparticle-supported palladium catalyst for the hydroxycarbonylation of aryl halides in water
Wittmann, Sebastian,Schaetz, Alexander,Grass, Robert N.,Stark, Wendelin J.,Reiser, Oliver
supporting information; experimental part, p. 1867 - 1870 (2010/06/21)
Boomerang catalysis: A catalyst catchrelease system Is established by the noncovalent attachment of a Pd N-heterocyclic carbene complex to graphene-coated magnetic Co nanoparticles. The immobilization by pyrene tags (see scheme; blue) is reversible at elevated temperatures, releasing the homogeneous catalyst. The hydroxycarbonylation of aryl halides is performed in 16 iterative reactions with this highly active catalyst. (Figure Presented)
Facile cleavage of ethers in ionic liquid
Cheng, Lili,Aw, Carlin,Ong, Siew Siang,Lu, Yixin
supporting information; experimental part, p. 2008 - 2010 (2009/08/14)
Various alkyl ethers were efficiently cleaved by treating them with pyridinium halides in ionic liquid, and the desired products were obtained in excellent yields.
Total synthesis of pterosines B and C via a photochemical key step
Wessig, Pablo,Teubner, Janek
, p. 1543 - 1546 (2007/10/03)
A total synthesis of pterosines B and C is reported. Starting with a fourfold substituted benzene derivative, the introduction of the remaining substituents is mainly based on Sonogashira couplings followed by different transformations of the ethyne moiety. The key step is a photochemical ring-closure of an α-mesyloxy ketone forming the 1-indanone skeleton. Georg Thieme Verlag Stuttgart.
Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists
Lu, Yixin,Lum, Tze Keong,Augustine, Yoon Wui Leow,Weltrowska, Grazyna,Nguyen, Thi M.-D.,Lemieux, Carole,Chung, Nga N.,Schiller, Peter W.
, p. 5382 - 5385 (2007/10/03)
3-(2,6-Dimethyl-4-carbamoylphenyl)propanoic acid (Dcp), a 2′,6′-dimethyltyrosine analogue containing a carbamoyl group in place of the hydroxyl function and lacking the amino group, was synthesized. The replacement of Tyr1 in an enkephalin analogue and in dynorphin A(1-11)-NH2 with Dcp resulted in the first opioid peptide-derived antagonists that do not contain a phenolic hydroxyl group at the 1-position residue. The cyclic peptide Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH 2 represents a novel, potent μ opioid antagonist.
A simple debenzylation of O-substituted phenol ethers using hydrobromic acid in presence of phase transfer catalyst
Bhalerao,Raju,Neelakantan
, p. 1433 - 1439 (2007/10/02)
A simple methodology for the debenzylation of ortho substituted phenol ethers in two phase system with aqueous hydrobromic acid in the presence of tetrabutylammonium bromide as a phase transfer catalyst is described.
