4928-87-4Relevant articles and documents
Self-assembly of novel manganese (II) compounds based on bifunctional-group ligands: Synthesis, structures, and magnetic properties
Yan, Juan-zhi,Lu, Li-ping,Zhu, Miao-li,Feng, Si-si
, p. 351 - 359 (2018)
Four manganese (II) compounds are obtained by the reaction of manganese salts, triazole-derivatives and auxiliary reagents in aqueous solution or mix-solvents by routine or hydrothermal reactions. X-ray crystal structure analyses reveal that a neutral 0D compound [Mn(Hmctrz)2(H2O)2] (1) (H2mctrz = 1H-1,2,4-triazole-3-carboxylic acid) displays a centro-symmetric mononuclear octahedral entity with two Hmctrz? anions and two water molecules; two neutral 2D clusters [Mn(Hdctrz)(H2O)2]n (2) (H3dctrz = 1H-1,2,4-triazole-3,5-dicarboxylic acid) and [Mn2(pbtrz)(btca)]n·4nH2O (3) (pbtrz = 1,3-bis(1,2,4-triazol-1-yl)-propane&H4btca = benzene-1,2,4,5-tetracarboxylic acid) possess layer structures with Hdctrz2? linkers (2) and Mn(II)-pbtrz-Mn(II) building blocks periodically extended by μ-btca4? connectors (3); [Mn(pbtrz)]n·nOAc·nOH (4) shows a 3D diamond-shaped cationic framework with the anion void volume of 49.2%. Nitrogenous bases are used as the auxiliary ligand in compound 3 and the temple ligand in compounds 1, 2, and 4. Compounds 1–4 show antiferromagnetic coupling that has been fitted by different models with the molecular field approximate with D = ? 0.129(1) cm?1 for 1, J = ? 0.354(4) cm?1 for 2 and J = ? 0.696(6) cm?1 for 3, respectively. The magnetic differences can be related to different superexchange interactions transmitted by the crystal lattice and/or the zero field splitting (ZFS) of the 6A1g single-ion states of 1 and the syn-anti-COO? of 2 as well as the mixed magnetic bridges of μ1-O and μ-pbtrz-μ-COO? of 3.
Preparation method of 1-methyl-1H-1,2,4-triazole-3-methyl formate
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Paragraph 0021-0036, (2021/09/01)
The invention discloses a preparation method of 1-methyl-1H-1,2,4-triazole-3-methyl formate, belonging to the technical field of organic synthesis. The method comprises the following steps: with aminoguanidine bicarbonate and oxalic acid as raw materials, adding inorganic strong base for cyclization to obtain 3-aminotriazole-5-carboxylic acid; then subjecting 3-aminotriazole-5-carboxylic acid to reacting with sodium nitrite under an acidic condition to obtain diazonium salt; then subjecting diazonium salt to reacting with hypophosphorous acid to obtain 1,2,4-triazole-3-carboxylic acid; and then subjecting 1,2,4-triazole-3-carboxylic acid to reacting with a methylation reagent to obtain 1-methyl-1H-1,2,4-triazole-3-methyl formate. The method is simple to operate, raw materials are easy to obtain, and economic applicability of the method is high.
Chemoenzymatic method of 1,2,4-triazole nucleoside synthesis: Possibilities and limitations
Konstantinova,Chudinov,Fateev,Matveev,Zhurilo,Shvets,Miroshnikov
, p. 53 - 71 (2013/04/10)
Possibilities and limitations of chemoenzymatic synthesis of novel structural analogues of an antiviral preparation of Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were established. A synthesis of various amides of 1H-1,2,4-triazole-3-carboxylic acid and its 5-substituted analogues - potential substrates of purine nucleoside phosphorylase - has been described. Comparative efficiency of preparation methods of these amides, as well as the methods of introduction of functional groups to the C5 position of heterocyclic system, were investigated. Novel analogues of Ribavirin containing various substitutes in the carboxamide group were synthesized. A biotechnological method was developed for the preparation of 1-β-D-ribofuranozyl-1,2,4-triazole-3-carbonitryl, an intermediate in the synthesis of Viramidine, the modern analogue of Ribavirin.
