49830-37-7

Basic information

• Product Name: 1-Aminocyclopentane carbonitrile
• Synonyms: A80241;1-aminocyclopentanecarbonitrile(SALTDATA: HCl);Cyclopentanecarbonitrile,1-amino-;Irbint-A01
• CAS NO: 49830-37-7
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.16
• Mol File: 49830-37-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 217°Cat760mmHg
• Flash Point: 85°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.136mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.18±0.20(Predicted)
• CAS DataBase Reference: 1-Aminocyclopentane carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminocyclopentane carbonitrile(49830-37-7)
• EPA Substance Registry System: 1-Aminocyclopentane carbonitrile(49830-37-7)

Safety Data

• Hazardous Substances Data: 49830-37-7(Hazardous Substances Data)

Usage

Description

1-Aminocyclopentane carbonitrile, also known as 1-cyano-1-aminocyclopentane, is a chemical compound with the molecular formula C6H10N2. It is a cyclic amine with a nitrile group attached to the cyclopentane ring, known for its unique structural features and potential pharmaceutical properties.

Uses

Used in Organic Synthesis:
1-Aminocyclopentane carbonitrile is used as a building block in organic synthesis for the creation of various biologically active molecules, leveraging its versatile chemical structure.
Used in Pharmaceutical Research:
In pharmaceutical research, 1-Aminocyclopentane carbonitrile is utilized as a building block for the synthesis of compounds with potential therapeutic applications, due to its ability to be incorporated into diverse molecular frameworks.
Used in Coordination Chemistry:
1-Aminocyclopentane carbonitrile is used as a ligand in coordination chemistry, contributing to the formation of metal complexes with specific properties and applications.
Used in Catalysis:
1-Aminocyclopentane carbonitrile also serves as a catalyst or a component in catalytic systems, facilitating chemical reactions in various industrial processes.
Used in Medicinal Chemistry for GABA Uptake Inhibition:
1-Aminocyclopentane carbonitrile is studied for its potential as a GABA uptake inhibitor, a property that may contribute to the development of treatments for neurological disorders.
Used in Medicinal Chemistry for Anticancer Properties:
Furthermore, it has been investigated for its anticancer properties, indicating its potential use in the development of novel cancer therapeutics.

InChI:InChI=1/C6H10N2/c7-5-6(8)3-1-2-4-6/h1-4,8H2

Upstream product

• 5117-85-1 1-hydroxycyclopentanecarbonitrile 
• 120-92-3 cyclopentanone 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 1003-03-8 Cyclopentamine 
• 773837-37-9 sodium cyanide 
• 7664-41-7 ammonia 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 67-64-1 acetone 

Downstream Products

• 6636-92-6 1-anilinocyclopentanecarbonitrile 
• 74002-22-5 cyclopentanimine 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 
• 10316-79-7 (1-aminocyclopentyl)methanol 
• 1265634-43-2 5-(4-chlorophenyl)-N-(1-cyanocyclopentyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 92398-48-6 1-aminocyclopentanecarboxylic acid hydrochloride 
• 194984-24-2 1-cyano-1-n-pentanoylaminocyclopentane 
• 915086-69-0 4-(4-imino-2-thioxo-1,3-diazaspiro[4.4]non-3-yl)-2-trifluoromethylbenzonitrile 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 83521-99-7 cyclopentanespiro-4'-imidazolidine-2',5'-dithione 
• 91806-24-5 1-Benzoylamino-cyclopentylnitril 
• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 
• 877273-12-6 N-(1-cyanocyclopentyl)-13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxamide 

Relevant articles and documents

Total syntheses of (±)-massadine and massadine chloride

The total syntheses of the complex pyrrole-imidazole alkaloids (±)-massadine and (±)-massadine chloride is described using a carefully orchestrated sequence of manipulations on highly polar and structurally complex intermediates. Key to the completion of this synthetic endeavor was the exploration of a unique and chemoselective method to oxidize unprotected guanidines under aqueous conditions in air. This oxidation has been optimized and applied to a selection of spirocyclic guanidines of varying complexity. Additionally, the 3,7-epi analogues of these interesting natural products have been synthesized and fully characterized. Copyright

Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs

The reaction of bromo-substituted chalcones with various diamino-compounds leads to the fused heterocyclic products, aziridinylpiperazines, exhibiting photoreactivity in the crystalline state. Crystals of 4-nitrosubstituted compounds of this family change their color from yellowish to deep violet-blue, 4-cyanosubstituted ones – from yellowish to pink at UV irradiation. Discussion on the mechanism of this phototransformation is still in progress, however, several facts points to the free radial nature of the photogenerated colored semi-products stabilized only by crystalline state of the irradiated samples. Formation of a mixture of positional isomers at interaction of bromo-chalcones with asymmetric diamines of aliphatic/alicyclic or aromatic series at synthesis of the title compounds is of significant interest as well.

A Sustainable, Semi-Continuous Flow Synthesis of Hydantoins

Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps and often use reagents that are not commercially available or sustainable. Herein, an efficient process is described for accessing hydantoins starting from commercially available amines using consecutive gas–liquid transformations (oxygen, carbon dioxide). This semi-continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52–84 %).