502-97-6

Basic information

• Product Name: 1,4-Dioxane-2,5-dione
• Synonyms: Glycollide;p-Dioxane-2,5-dione;GLYCOLIDE;GLYCOLIDE A;1,4-DIOXAN-2,5-DIONE;1,4-DIOXANE-2,5-DIONE;PURASORB(R) G;1,4-Dioxane-2,5-dione,97%
• CAS NO: 502-97-6
• Molecular Formula: C₄H₄O₄
• Molecular Weight: 116.07
• EINECS: 207-954-9
• Mol File: 502-97-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 81-83°C
• Boiling Point: 130°C(lit.)
• Flash Point: 181.5 °C
• Appearance: white crystalline solid
• Density: 1.1315 (rough estimate)
• Vapor Pressure: 0.000279mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• Storage Temp.: ?20°C
• Solubility: Dichloromethane (Slightly), DMSO (Slightly)
• CAS DataBase Reference: 1,4-Dioxane-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxane-2,5-dione(502-97-6)
• EPA Substance Registry System: 1,4-Dioxane-2,5-dione(502-97-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 22-24/25-37/39-26
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 502-97-6(Hazardous Substances Data)

Usage

Chemical Properties

mp 82-86°C 99.5+%

Uses

1,4-Dioxane-2,5-dione is used in the fabricating of artificial blood vessels.

General Description

Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2

Upstream product

• 79-11-8 chloroacetic acid 
• 79-14-1 glycolic Acid 
• 71-41-0 pentan-1-ol 
• 111-27-3 hexan-1-ol 
• 111-70-6 n-heptan1ol 
• 111-87-5 octanol 
• 112-30-1 1-Decanol 
• 71-23-8 propan-1-ol 
• 67-56-1 methanol 
• 71-36-3 butan-1-ol 
• 64-17-5 ethanol 
• 23147-58-2 glycolaldehyde dimer 
• 96-35-5 glycolic acid methyl ester 
• 30450-82-9 chloroacetyl glycolic acid 

Downstream Products

• 79-14-1 glycolic Acid 
• 4746-61-6 glycolanilide 
• 103-70-8 Formanilid 
• 96-35-5 glycolic acid methyl ester 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 90357-58-7 n-propyl 2-hydroxyacetate 
• 623-50-7 ethyl 2-hydroxyacetate 
• 7397-62-8 butyl glycolate 
• 39096-01-0 N,N-diethyl-2-hydroxyacetamide 
• 14658-93-6 2-hydroxy-N,N-dimethylacetamide 
• 90204-88-9 N-cyclohexyl-2-hydroxyacetamide 
• 138-86-3 limonene. 
• 117356-20-4 (1R,2S,5R)-2-isopropyl-5-methylcyclohex-1-yl hydroxyacetate 
• 110271-85-7 methyl glycolylglycolate 

Relevant articles and documents

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PROCESS FOR PREPARING GLYCOLIDE

According to the present invention a process is provided for producing glycolide which comprises contacting glycolaldehyde dimer with an oxidizing agent to produce a glycolide product.Preferably, the process is carried out in an aprotic environment, such as in a reaction mixture comprising the glycolaldehyde dimer, the oxidizing agent, the glycolide product and an aprotic solvent.

METHOD FOR PRODUCING GLYCOLIDE

PROBLEM TO BE SOLVED: To provide a method for producing glycolides, with which glycolides can be produced more rapidly. SOLUTION: The method for producing glycolides comprises: an oligomer preparation step for obtaining a glycolic acid oligomer by heating an aqueous glycolic acid solution and by the dehydropolycondensation of the glycolic acid contained in the aqueous glycolic acid solution; and a depolymerization step for obtaining a glycolide by depolymerization of the glycolic acid oligomer in the presence of divalent iron ions. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT