39096-01-0

Basic information

• Product Name: 2-HYDROXY-N,N-DIETHYLACETAMIDE
• Synonyms: N,N-DIETHYL-2-HYDROXYACETAMIDE;N,N-DIETHYLGLYCOLAMIDE;2-HYDROXY-N,N-DIETHYLACETAMIDE;N,N-Diethyl-2-hydroxyacetamide 96%
• CAS NO: 39096-01-0
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.17
• Mol File: 39096-01-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 238 °C(lit.)
• Flash Point: 220 °F
• Appearance: /
• Density: 1.009 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0216mmHg at 25°C
• Refractive Index: n20/D 1.457(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: 2-HYDROXY-N,N-DIETHYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-N,N-DIETHYLACETAMIDE(39096-01-0)
• EPA Substance Registry System: 2-HYDROXY-N,N-DIETHYLACETAMIDE(39096-01-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 39096-01-0(Hazardous Substances Data)

Usage

Uses

N,N-Diethyl-2-hydroxyacetamide is a reactant used in the synthesis of phosphonate prodrugs to increase the oral bioavailability of an antiviral agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA).

InChI:InChI=1/C6H13NO2/c1-3-7(4-2)6(9)5-8/h8H,3-5H2,1-2H3

Upstream product

• 59875-48-8 2-acetoxy-N,N-diethylacetamide 
• 79-14-1 glycolic Acid 
• 109-89-7 diethylamine 
• 77077-06-6 N,N,N′,N′-tetraethyl diglycolamide 
• 3926-62-3 sodium monochloroacetic acid 
• 53056-21-6 2-(benzyloxy)-N,N-diethylacetamide 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 
• 533925-39-2 N,N-diethylcarbamoylmethyl 2-[3-(trifluoromethyl)anilino]nicotinic ester 
• 4158-86-5 4-oxo-2,2-dimethyl-1,3-dioxolane 
• 86452-75-7 C₉H₂₁NO₂Sn 
• 502-97-6 glycolide 

Downstream Products

• 94299-71-5 α-(4-Chlorphenoxy)-isobuttersaeure-diethylcarbamoylmethylester 
• 76668-05-8 4,5-dichloro-2-thiazolyl-oxyacetic acid N,N-diethylamide 
• 1125674-20-5 3-phenylfuro[2,3-b]pyridine-2-carboxylic acid diethylamide 
• 1208229-58-6 (N,N-diethylcarbamoyl)methyl methyl (2E)-but-2-ene-1,4-dioate 
• 2430-01-5 2-bromo-N,N-diethylacetamide 
• 1387525-48-5 2-(cinnamyloxy)-N,N-diethylacetamide 
• 1387525-50-9 N,N-diethyl-2-(3-phenylpropoxy)acetamide 
• 1329602-24-5 2-{3-[(2,6-dioxocyclohexyl)carbonyl]-6-(methylsulfonyl)-2-(trifluoromethyl)phenoxy}-N,N-diethylacetamide 
• 175728-35-5 N,N-diethyl-2-t-butyldiphenylsilyloxy-4-pentenamide 

Relevant articles and documents

ADENOSINE RECEPTOR BINDING COMPOUNDS

The present invention relates to pharmaceutical compounds and compositions of Formula (I) and methods of treatment using the compounds and compositions, especially for the treatment and/or prevention of a proliferation disorder, such as cancer. Compounds of Formula (I) as further described herein are shown modulators of the adenosine A2A receptor and exhibit antiproliferative activity. Accordingly, these compounds are useful to treat proliferative disorders such as cancer, and other adenosine receptor-related conditions including an inflammatory disease, renal disease, diabetes, vascular disease, lung disease, or an autoimmune disease.

METHOD FOR PRODUCING MONOMETHYL FUMARATE COMPOUNDS

The present invention relates to a novel method for preparing monomethyl fumarate, which can preferably be used in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases such as multiple sclerosis and psoriasis. Further, the present invention relates to the use of specific compounds as intermediates in the process for preparing a monomethyl fumarate prodrug.

Development of 3-methoxy-4-benzyloxybenzyl alcohol (MBBA) resin as polymer-supported synthesis support: Preparation and benzyl ether cleavage by DDQ oxidation

3-Methoxy-4-benzyloxybenzyl alcohol (MBBA) resin was synthesized by a two-step sequence under microwave irradiation involving the reaction of commercially available Merrifield resin with vanillin, followed by reduction with sodium borohydride. MBBA resin was treated with bromides in the presence of sodium hydride to afford the corresponding resin-bound benzyl ethers. Cleavage of the resin-bound benzyl ethers from the MBBA resin was carried out using 2,3-dichloro-5,6-dicyanobenzoqunone (DDQ) to give the corresponding alcohols in good yields. Moreover, the recovery, regeneration, and reuse of this polymer support could be achieved easily. MBBA resin can be developed as a kind of solid-phase synthesis bead of alcohols. Indian Academy of Sciences.