5183-78-8

Basic information

• Product Name: N-METHYLBENZENESULFONAMIDE
• Synonyms: N-METHYLBENZENESULFONAMIDE;n-methyl-benzenesulfonamid;BENZENESULFONYL-N-METHYLAMIDE;N-methylbenzenesulphonamide;N-Methylbenzenesulfonamide
• CAS NO: 5183-78-8
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• EINECS: 225-965-7
• Mol File: 5183-78-8.mol
• Article Data: 47

Chemical Properties

• Melting Point: 31 °C
• Boiling Point: 284 °C at 760 mmHg
• Flash Point: 125.6 °C
• Appearance: /
• Density: 1.222 g/cm³
• Vapor Pressure: 0.00305mmHg at 25°C
• Refractive Index: 1.538
• PKA: 11.43±0.30(Predicted)
• Water Solubility: It is soluble in water.
• CAS DataBase Reference: N-METHYLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLBENZENESULFONAMIDE(5183-78-8)
• EPA Substance Registry System: N-METHYLBENZENESULFONAMIDE(5183-78-8)

Safety Data

• Safety Statements: 22-24/25
• TSCA: Yes
• Hazardous Substances Data: 5183-78-8(Hazardous Substances Data)

Usage

Uses

N-Methylbenzenesulfonamide, is used as an intermediate in industry.

InChI:InChI=1/C7H9NO2S/c1-8-11(9,10)7-5-3-2-4-6-7/h2-6,8H,1H3

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 74-89-5 methylamine 
• 42060-55-9 N-benzyl-N-methylbenzenesulfonamide 
• 7647-01-0 hydrogenchloride 
• 860514-64-3 N,N'-dimethyl-N,N'-(2-methyl-2-aza-propanediyl)-bis-benzenesulfonamide 
• 14417-01-7 N,N-dimethylbenzenesulfonamide 
• 20044-77-3 N-Methyl-N-propargyl-benzolsulfonamid 
• 956283-09-3 (2-(N-methyl-sulfamoyl)-phenyl)boronic acid 
• 616-91-1 N-acetylcystein 
• 108-98-5 thiophenol 
• 593-51-1 methylamine hydrochloride 
• 221526-66-5 methyl N-benzenesulfonyl-L-serinate 
• 98-10-2 benzenesulfonamide 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 112323-55-4 1,4-bis-[(benzenesulfonyl-methyl-amino)-methyl]-piperazine 
• 29019-38-3 N,N'-dimethylbenzoamidine 
• 25096-90-6 N-methyl-N-vinyl-benzenesulfonamide 
• 52072-79-4 N-Chlorsulfonyl-N'-methyl-N'-phenylsulfonylharnstoff 
• 15448-99-4 N-methylsaccharin 
• 66896-73-9 N-Methyl-N-(2-methyl-benzoyl)-benzenesulfonamide 
• 66896-71-7 N-(2,4-Dichloro-benzoyl)-N-methyl-benzenesulfonamide 
• 98-10-2 benzenesulfonamide 
• 4917-54-8 N-formyl benzenesulfonamide 
• 14665-62-4 4--1-methoxybenzene 
• 92851-29-1 N-(4-Acetyl-phenyl)-N-methyl-benzenesulfonamide 
• 71836-03-8 N,N'-dimethyl-N,N'-disulfanediyl-bis-benzenesulfonamide 
• 219725-72-1 1-Diphenylmethyl-3-(N-methyl benzenesulphonamido)azetidine 
• 573717-52-9 N-methyl-N-(4-trifluoroacetyl-phenyl)-benzenesulfonamide 

Relevant articles and documents

N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls

The photochemical fragmentation of N-aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous-flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by-products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.

Electrochemical C?H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium

The construction of C?N bonds by free radical reactions represents a powerful synthetic approach for direct C?H amidations of arenes or heteroarenes. Developing efficient and more environmentally friendly synthetic methods for C?H amidation reactions remains highly desirable. Herein, metal-free electrochemical oxidative dehydrogenative C?H amidations of heteroarenes with N-alkylsulfonamides have been accomplished. The catalyst- and chemical-oxidant-free C?H amidation features an ample scope and employs electricity as the green and sole oxidant. A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp2)?H nitrogenation. Cyclic voltammetry studies and control experiments provided evidence for nitrogen-centered radicals being directly generated under metal-free electrocatalysis.

Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalysts for hydrogen autotransfer process.