537-55-3 Usage
Chemical Properties
N-Acetyl-L-Tyrosine is a white crystalline powder that is an acetyl derivative of the amino acid, L-tyrosine. It is freely soluble in water compared to L-tyrosine and is commonly used as a parenteral nutrition supplement. N-Acetyl-L-tyrosine , a stable and more soluble form of tyrosine , has been incorporated in some currently available commercial parenteral amino acid formulations such as TrophAmine and Aminosyn-II.
Uses
N-Acetyl-L-tyrosine is involved in catecholamine production. It can be used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Definition
ChEBI: N-acetyl-L-tyrosine is an N-acetyltyrosine in which the chiral centre has L configuration. It has a role as an EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor, a biomarker and a human urinary metabolite. It is a N-acyl-L-tyrosine and a N-acetyltyrosine. It is a conjugate acid of a N-acetyl-L-tyrosinate.
Application
N-Acetyl-L-tyrosine is a tyrosine derivative with a chemical structure similar to that of an amino acid. It is used as a model system in biochemistry and molecular biology to study the transfer reactions of tyrosine, which are important for energy metabolism, protein synthesis, and metal chelation. N-acetyl-L-tyrosine may be used as an indicator to distinguish neurosyphilis patients from syphilis/non-neurosyphilis patients. N-acetyl-L-tyrosine is a precursor of the essential neurotransmitter dopamine.
benefits
N-Acetyl-L-Tyrosine (NALT) plays a necessary part in the synthesis of dopamine and other hormones in your body. It can boost levels of the neurotransmitters dopamine, norepinephrine and epinephrine. It helps to support higher levels of focus and cognitive function. It can increase working memory and feelings of well-being.
Side effects
L-tyrosine gets the generally regarded as safe (GRAS) stamp of approval from the FDA. Some side effects of N-Acetyl-L-tyrosine (NALT) include nausea, headache, fatigue, and heartburn. It can be safely taken for extended periods of time.
Check Digit Verification of cas no
The CAS Registry Mumber 537-55-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 7 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 537-55:
(5*5)+(4*3)+(3*7)+(2*5)+(1*5)=73
73 % 10 = 3
So 537-55-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/p-1/t10-/m0/s1
537-55-3Relevant articles and documents
Unusual Enhancement of Protease Activity in Organic Solvents by Amines
Yamamoto, Yasuhito,Kise, Hideo
, p. 1821 - 1824 (1993)
The catalytic activities of subtilisin BPN' and α-chymotrypsin for transesterification of N-acetyl-L-tyrosine methyl ester in organic solvents were dramatically increased by addition of tertiary amines.The effects may be ascribed to the change in dissociation state of polar groups on the surface of the enzymes.
Effect of dioxane on the binding of competitive inhibitor proflavin and catalytic activity of bovine pancreatic α-chymotrypsin
Sirotkin,Mukhametzyanov,Karmanova
, p. 1160 - 1164 (2007)
The binding of competitive inhibitor proflavin by α-chymotrypsin in water-dioxane mixtures over the entire range of thermodynamic activities of water a w was studied. The data on the degree of binding of proflavin were compared to the results on the catalytic activity of the enzyme preliminary incubated in water-dioxane mixtures. An analysis of the behavior of the concentration dependences of these characteristics demonstrated that, at low a w values, the behavior of the interprotein contacts in the enzyme formed during its drying largely governs its functional properties, while at high a w values, they are determined by the interaction of the enzyme with the organic solvent. Interplay of these two factors is responsible for the observed complex shape of the isotherm of binding of proflavin, with the maximum degree of binding being attained at moderate a w values.
GRANZYME B DIRECTED IMAGING AND THERAPY
-
Page/Page column 82; 98, (2019/09/04)
Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.
Radical arylation of tyrosine residues in peptides
Fehler, Stefanie K.,Pratsch, Gerald,?streicher, Christiane,Fürst, Michael C.D.,Pischetsrieder, Monika,Heinrich, Markus R.
supporting information, p. 7888 - 7893 (2016/11/17)
The radical arylation of the phenolic side chain of tyrosine in peptides was investigated. Aryl radicals were generated from aryldiazonium salts using titanium(III) chloride as stoichiometric reductant. Due to the high selectivity with which 3-aryltyrosine derivatives were formed, this reaction type represents a new strategy for the direct functionalization of peptides.
