5554-57-4

Basic information

• Product Name: (2E)-3-(4-methylphenyl)-N-[(4-sulfamoylphenyl)carbamothioyl]prop-2-enamide
• CAS NO: 5554-57-4
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 375.4652
• Mol File: 5554-57-4.mol
• Article Data: 70

Chemical Properties

• Density: 1.406g/cm³
• Refractive Index: 1.685
• CAS DataBase Reference: (2E)-3-(4-methylphenyl)-N-[(4-sulfamoylphenyl)carbamothioyl]prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-methylphenyl)-N-[(4-sulfamoylphenyl)carbamothioyl]prop-2-enamide(5554-57-4)
• EPA Substance Registry System: (2E)-3-(4-methylphenyl)-N-[(4-sulfamoylphenyl)carbamothioyl]prop-2-enamide(5554-57-4)

Safety Data

• Hazardous Substances Data: 5554-57-4(Hazardous Substances Data)

Usage

General Description

The chemical (2E)-3-(4-methylphenyl)-N-[(4-sulfamoylphenyl)carbamothioyl]prop-2-enamide, also known as Sulfamethoxazole, is an antimicrobial medication used to treat a variety of bacterial infections. Sulfamethoxazole works by inhibiting the production of folic acid in bacteria, ultimately leading to their death. It is commonly used in combination with trimethoprim, and together they form the antibiotic co-trimoxazole, which is effective in treating urinary tract infections, bronchitis, and pneumocystis pneumonia. Sulfamethoxazole is generally well-tolerated, but can cause side effects such as nausea, vomiting, and skin rashes. It is important to use this medication as prescribed and to complete the full course of treatment in order to effectively clear the infection.

Upstream product

• 37418-37-4 t⁽³⁾-methyl-r⁽²⁾,c⁽⁶⁾-diphenylpiperidin-4-one 
• 100-52-7 benzaldehyde 
• 78-93-3 butanone 
• 502960-95-4 C₁₉H₂₂N₄S 
• 79-04-9 chloroacetyl chloride 
• 1187457-12-0 C₂₁H₂₂N₄OS 
• 201335-57-1 3-methyl-2,6-diphenylpiperidin-4-one semicarbazone 
• 631-61-8 ammonium acetate 
• 20821-59-4 3-methyl-2,6-diphenylpiperidin-4-one hydrochloride 
• 136661-48-8 1-Acetyl-3-methyl-2,6-diphenyl-piperidin-4-one 
• 129224-56-2 t-3-Methyl-N-nitroso-r-2,c-6-diphenylpiperidin-4-one 
• 87731-83-7 r-2,t-3,t-5,c-6-Tetraphenylpiperidin-4-one 
• 89757-54-0 3-Butyl-1-chloro-2,6-diphenyl-piperidin-4-one 
• 87621-16-7 N-Chloro-3,5-dimethyl-2,6-diphenylpiperidin-4-one 

Downstream Products

• 65433-90-1 3-methyl-4-ethyl-2,6-diphenylpiperidin-4-ol 
• 120425-82-3 r-2,c-6-diphenyl-t-3-piperidine 
• 87731-90-6 1-Methyl-2,4-diphenyl-6,8-bis<4-methylphenyl>-3,7-diazabicyclo<3.3.1>nonan-9-one 
• 69130-89-8 N-chloro-3-methyl-2,6-diphenylpiperidin-4-one 
• 89757-55-1 1-Chloro-2,3,5,6-tetraphenyl-piperidin-4-one 
• 79588-04-8 4-amino-4-cyano-3-methyl-2,6-diphenylpiperidine 
• 143602-86-2 3-methyl-2,6-diphenyl-N-phenylcarbamoylpiperidin-4-one 
• 129224-56-2 t-3-Methyl-N-nitroso-r-2,c-6-diphenylpiperidin-4-one 
• 127895-92-5 C₁₈H₁₅⁽²⁾H₄NO 
• 145147-09-7 t-3-Methyl-r-2,c-6-diphenylpiperidine hydrochloride 
• 65-85-0 benzoic acid 
• 37418-37-4 t⁽³⁾-methyl-r⁽²⁾,c⁽⁶⁾-diphenylpiperidin-4-one 
• 64292-73-5 (+/-)-3c-methyl-2t,6t-diphenyl-piperidin-4r-ol 
• 64292-73-5 (+/-)-3t-methyl-2c,6c-diphenyl-piperidin-4r-ol 

Relevant articles and documents

Synthesis and characterization of piperidin-4-one derivatives using green solvent

A deep eutectic solvent of glucose-urea was found to be an inexpensive and effective reaction medium in the synthesis of piperidin-4-one derivatives. In this work, 3-methyl-2,6-diphenyl piperidin-4-one (4a), 3,5-dimethyl-2,6-diphenylpiperidin-4-one (4b), 2,6-diphenylpiperidin-4-one (4c), piperidin-4-one (4d), 3,5-dimethylpiperidin-4-one (4e), 3-methyl-2,6-di(2-hydroxyphenyl)piperidin-4-one (4f), 3,5-dimethyl 2,6-di(2-hydroxyphenyl)piperidin-4one (4g) were synthesized using a deep eutectic solvent (DES) of glucose and urea with the percentage composition of 60:40. The yields of these products were 82, 78, 75, 68, 72, 70 and 70 %, respectively. The products obtained were characterized by FT-IR and 1H NMR spectroscopic techniques. A synthesis of piperidin-4-one derivatives by using this green solvent was considered to be new environmentally safe synthetic method.

Design, synthesis, molecular docking and antimicrobial evaluation of some tosyl carbamate derivatives

A series of tosyl carbamates have been synthesized and screened for their antibacterial and antifungal activities. All the synthesized compounds were characterized by spectral techniques (IR, 1H, 13C NMR and mass) and elemental analysis. in silico Molecular docking method was performed to study their antimicrobial activity against the target protein 1T9U. Compound 27 showed good antibacterial activity against Gram-positive and Gram-negative bacterial strains and compound 19 showed good antifungal activity. Molecular docking results revealed that the compound 19 exhibits minimum CDOCKER energy. Tosyl carbamate derivatives having good antimicrobial activities compared to that standard and all the synthesized compounds exhibits moderate CDOCKER scores.

New thiazoldinone substituted 2,6-diarypiperidin-4-one: Synthesis, crystal structure, spectral characterization, binding mode with calf thymus DNA

A series of 2,6-diarylpiperidin-4-ylidene thiazolidin-4-one derivatives (15–21) were efficiently synthesized using a green and recyclable catalyst Amberlit IR-120H resin under microwave irradiation. All the compounds were characterized by elemental analys