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5724-76-5

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5724-76-5 Usage

General Description

3-(2,5-dioxopyrrolidin-1-yl)propanoic acid, also known as Diketopiperazine (DKP), is a cyclic dipeptide derivative that is commonly found in various natural products and pharmaceutical compounds. It is a synthetic intermediate in the production of pharmaceuticals and is used as a building block for the synthesis of complex molecules. DKP has been studied for its potential biological activities, including anti-inflammatory, antiviral, and anticancer properties. Additionally, it has been investigated for its potential use in drug delivery systems and as a drug stabilizer. The compound is considered to be of interest in the field of medicinal chemistry and drug development due to its diverse pharmacological activities and potential applications in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 5724-76-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,2 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5724-76:
(6*5)+(5*7)+(4*2)+(3*4)+(2*7)+(1*6)=105
105 % 10 = 5
So 5724-76-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H9NO4/c9-5-1-2-6(10)8(5)4-3-7(11)12/h1-4H2,(H,11,12)

5724-76-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(2,5-dioxopyrrolidin-1-yl)propanoic acid

1.2 Other means of identification

Product number -
Other names 3-(2,5-Dioxo-pyrrolidin-1-yl)-propionic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5724-76-5 SDS

5724-76-5Relevant articles and documents

Maleimide conjugates of saxitoxin as covalent inhibitors of voltage-gated sodium channels

Parsons, William H.,Du Bois

, p. 10582 - 10585 (2013)

(+)-Saxitoxin, a naturally occurring guanidinium poison, functions as a potent, selective, and reversible inhibitor of voltage-gated sodium ion channels (NaVs). Modified forms of this toxin bearing cysteine-reactive maleimide groups are available through total synthesis and are found to irreversibly inhibit sodium ion conductance in recombinantly expressed wild-type sodium channels and in hippocampal nerve cells. Our findings support a mechanism for covalent protein modification in which toxin binding to the channel pore precedes maleimide alkylation of a nucleophilic amino acid. Second-generation maleimide-toxin conjugates, which include bioorthogonal reactive groups, are also found to block channel function irreversibly; such compounds have potential as reagents for selective labeling of NaVs for live cell imaging and/or proteomics experiments.

Regioselective β-Csp3-Arylation of β-Alanine: An Approach for the Exclusive Synthesis of Diverse β-Aryl-β-amino Acids

Chowdhury, Sushobhan,Vaishnav, Roopal,Panwar, Namita,Haq, Wahajul

, p. 2512 - 2522 (2019/03/07)

An approach for the synthesis of a variety of new β-aryl-β-amino acids has been developed via a palladium-catalyzed auxiliary-directed regioselective Csp3-H arylation of the unactivated β-methylene bond of β-alanine. The use of 8-aminoquinoline amide as an auxiliary efficiently directs the desired regioselective β-Csp3-H functionalization. The developed protocol enables the easy and straightforward access to several high-value β-aryl-β-amino acids useful for peptide engineering, starting from inexpensive and readily available β-alanine precursors in moderate to excellent yields.

Sulfonium ylides 7. Influence of substituents in the imide fragment on the regioselectivity of intramolecular cyclization of phthalimido-containing keto-stabilized sulfonium ylides

Galin,Lakeev,Tolstikov

, p. 1904 - 1908 (2007/10/03)

The intramolecular cyclization of keto-stabilized sulfonium ylides obtained from β-alanine and containing various imide fragments was studied. On heating in toluene in the presence of PhCO2H, ylides containing a phthalimide moiety are converted into indolizidine-2,6-dione derivatives, whereas those incorporating a 4-methyl-1,2,3,6-tetrahydrophthalimide or pyrrolidine-2,5-dione moieties do not undergo cyclization.

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