577-68-4

Basic information

• Product Name: m-Hemipinic acid
• Synonyms: 4,5-Dimethoxy-1,2-benzenedicarboxylic acid;4,5-Dimethoxyphthalic acid;Metahemipinic acid;m-hemipic acid;m-Hemipinic acid
• CAS NO: 577-68-4
• Molecular Formula: C₁₀H₁₀O₆
• Molecular Weight: 226.1828
• Product Categories: Amines, Aromatics, Inhibitors, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 577-68-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 179 °C
• Boiling Point: 394.7°C at 760 mmHg
• Flash Point: 157.1°C
• Appearance: /
• Density: 1.391g/cm³
• Vapor Pressure: 6.15E-07mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 3.10±0.10(Predicted)
• CAS DataBase Reference: m-Hemipinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: m-Hemipinic acid(577-68-4)
• EPA Substance Registry System: m-Hemipinic acid(577-68-4)

Safety Data

• Hazardous Substances Data: 577-68-4(Hazardous Substances Data)

Usage

Uses

m-Hemipinic Acid is an intermediate in the synthesis of Carbazeran (C175790), a phosphodiesterase inhibitor drug that exhibits chronictropic and inotropic effects.

InChI:InChI=1/C10H10O6/c1-15-7-3-5(9(11)12)6(10(13)14)4-8(7)16-2/h3-4H,1-2H3,(H,11,12)(H,13,14)

Upstream product

• 483-18-1 (+-)-Emetin 
• 7721-62-2 4,5-dimethoxy-2-methylbenzaldehyde 
• 75833-55-5 4,5-bisacetoxymethylveratrole 
• 15248-39-2 6,7-dimethoxyisoquinoline 
• 7647-01-0 hydrogenchloride 
• 482-74-6 cryptopine 
• 7664-93-9 sulfuric acid 
• 483-17-0 cephaeline 
• 518-69-4 corydaline 
• 1054471-20-3 2-benzyl-5,6-dimethoxyisoindoline-1,3-dione 
• 27002-36-4 2-ethyl-5,6-dimethoxy-isoindole-1,3-dione 
• 53295-41-3 3,9,10-trimethoxy-7,11b-dihydro-indeno[2,1-c]chromen-6a-ol 
• 5485-14-3 NSC7241 
• 68907-92-6 2,3,7,8-tetramethoxy-10,11-dihydro-5H-10,5-azaethano-dibenzo[a,d]cycloheptene 

Downstream Products

• 645-08-9 Isovanillic acid 
• 63958-66-7 4,5-dihydroxyphthalic acid 
• 1431566-16-3 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5,6-dimethoxy-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide 
• 153356-62-8 3-bromo-4,5-dimethoxy-phthalic acid 
• 858442-56-5 3-bromo-4-hydroxy-5-methoxy-phthalic acid 
• 1006694-57-0 4,5-dihydroxyphthalic acid diethyl ester 
• 2043-87-0 4,5-diethoxy-phthalic acid 
• 99866-19-0 4-ethoxy-5-methoxy-phthalic acid 
• 50522-17-3 4-hydroxy-5-methoxy-phthalic acid dimethyl ester 
• 43073-12-7 4,5-dimethoxy-phthalaldehyde 
• 78219-03-1 1-(aminomethyl)-5,6-dihydroxyphthalide hydrobromide 
• 153356-71-9 (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-carboxy-1-methyl-ethoxyimino]-acetylamino}-3-(4,8-dichloro-5,7-dioxo-2,2-diphenyl-5,7-dihydro-[1,3]dioxolo[4,5-f]isoindol-6-ylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 134426-60-1 7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid 
• 153356-69-5 4,8-Dichloro-5,7-dioxo-2,2-diphenyl-5,7-dihydro-[1,3]dioxolo[4,5-f]isoindole-6-carboxylic acid ethyl ester 

Relevant articles and documents

Phthalimide-(N-alkylbenzylamine) cysteamide hybrids as multifunctional agents against Alzheimer’s disease: Design, synthesis, and biological evaluation

The complex pathogenesis of Alzheimer's disease (AD) calls for multi-target approach for disease treatment. Herein, based on the MTDLs strategy, a series of phthalimide-(N-alkylbenzylamine) cysteamide hybrids were designed, synthesized, and investigated i

A direct assay of butyrylcholinesterase activity using a fluorescent substrate

In this study, we report a direct fluorometric assay for butyrylcholinesterase (BChE) activity and screening of its inhibitor, using a fluorescent substrate. 2-(2-(5,6-Dimethoxy-1,3-dioxoisoindolin-2-yl)acetoxy)-N,N,N-trimethylethan-1-ammonium iodide (1)

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.